Importance of bone marrow cytogenetic evaluation before autologous bone marrow transplantation for Hodgkin's disease
Alkylating agents used either with or without radiation therapy have been associated with the development of myelodysplastic syndrome (MDS) and acute nonlymphoblastic leukemia (ANLL) after treatment of both malignant and nonmalignant disorders. This report describes seven patients with recurrent Hod...
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| Veröffentlicht in: | Journal of clinical oncology 1991-09, Vol.9 (9), p.1575-1579 |
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| container_title | Journal of clinical oncology |
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| creator | CHAO, N. J NADEMANEE, A. P LONG, G. D SCHMIDT, G. M DONLON, T. A PARKER, P SLOVAK, M. L NAGASAWA, L. S BLUME, K. G FORMAN, S. J |
| description | Alkylating agents used either with or without radiation therapy have been associated with the development of myelodysplastic syndrome (MDS) and acute nonlymphoblastic leukemia (ANLL) after treatment of both malignant and nonmalignant disorders. This report describes seven patients with recurrent Hodgkin's disease (HD) evaluated for bone marrow transplantation (BMT) who developed chromosomal abnormalities, and emphasizes the importance of bone marrow cytogenetic studies before bone marrow harvest. Three patients with histologically normal bone marrow underwent autologous BMT and subsequently developed an MDS or ANLL. Four patients had the clonal abnormality detected before bone marrow harvest and did not proceed to BMT. |
| doi_str_mv | 10.1200/JCO.1991.9.9.1575 |
| format | Article |
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J ; NADEMANEE, A. P ; LONG, G. D ; SCHMIDT, G. M ; DONLON, T. A ; PARKER, P ; SLOVAK, M. L ; NAGASAWA, L. S ; BLUME, K. G ; FORMAN, S. J</creator><creatorcontrib>CHAO, N. J ; NADEMANEE, A. P ; LONG, G. D ; SCHMIDT, G. M ; DONLON, T. A ; PARKER, P ; SLOVAK, M. L ; NAGASAWA, L. S ; BLUME, K. G ; FORMAN, S. J</creatorcontrib><description>Alkylating agents used either with or without radiation therapy have been associated with the development of myelodysplastic syndrome (MDS) and acute nonlymphoblastic leukemia (ANLL) after treatment of both malignant and nonmalignant disorders. This report describes seven patients with recurrent Hodgkin's disease (HD) evaluated for bone marrow transplantation (BMT) who developed chromosomal abnormalities, and emphasizes the importance of bone marrow cytogenetic studies before bone marrow harvest. Three patients with histologically normal bone marrow underwent autologous BMT and subsequently developed an MDS or ANLL. Four patients had the clonal abnormality detected before bone marrow harvest and did not proceed to BMT.</description><identifier>ISSN: 0732-183X</identifier><identifier>EISSN: 1527-7755</identifier><identifier>DOI: 10.1200/JCO.1991.9.9.1575</identifier><identifier>PMID: 1875219</identifier><language>eng</language><publisher>Baltimore, MD: American Society of Clinical Oncology</publisher><subject>Adult ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Bone Marrow - ultrastructure ; Bone Marrow Transplantation ; Bone marrow, stem cells transplantation. Graft versus host reaction ; Chromosome Aberrations ; Female ; Hodgkin Disease - genetics ; Hodgkin Disease - surgery ; Humans ; Male ; Medical sciences ; Middle Aged ; Transfusions. Complications. Transfusion reactions. Cell and gene therapy ; Translocation, Genetic ; Transplantation, Homologous</subject><ispartof>Journal of clinical oncology, 1991-09, Vol.9 (9), p.1575-1579</ispartof><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c355t-4e6f6b999e99777b8ef9e323c059b3489ef455cd16ea920596aa2ee8ff28151c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3715,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5087067$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1875219$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CHAO, N. J</creatorcontrib><creatorcontrib>NADEMANEE, A. P</creatorcontrib><creatorcontrib>LONG, G. D</creatorcontrib><creatorcontrib>SCHMIDT, G. M</creatorcontrib><creatorcontrib>DONLON, T. A</creatorcontrib><creatorcontrib>PARKER, P</creatorcontrib><creatorcontrib>SLOVAK, M. L</creatorcontrib><creatorcontrib>NAGASAWA, L. S</creatorcontrib><creatorcontrib>BLUME, K. G</creatorcontrib><creatorcontrib>FORMAN, S. J</creatorcontrib><title>Importance of bone marrow cytogenetic evaluation before autologous bone marrow transplantation for Hodgkin's disease</title><title>Journal of clinical oncology</title><addtitle>J Clin Oncol</addtitle><description>Alkylating agents used either with or without radiation therapy have been associated with the development of myelodysplastic syndrome (MDS) and acute nonlymphoblastic leukemia (ANLL) after treatment of both malignant and nonmalignant disorders. This report describes seven patients with recurrent Hodgkin's disease (HD) evaluated for bone marrow transplantation (BMT) who developed chromosomal abnormalities, and emphasizes the importance of bone marrow cytogenetic studies before bone marrow harvest. Three patients with histologically normal bone marrow underwent autologous BMT and subsequently developed an MDS or ANLL. Four patients had the clonal abnormality detected before bone marrow harvest and did not proceed to BMT.</description><subject>Adult</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Bone Marrow - ultrastructure</subject><subject>Bone Marrow Transplantation</subject><subject>Bone marrow, stem cells transplantation. Graft versus host reaction</subject><subject>Chromosome Aberrations</subject><subject>Female</subject><subject>Hodgkin Disease - genetics</subject><subject>Hodgkin Disease - surgery</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</subject><subject>Translocation, Genetic</subject><subject>Transplantation, Homologous</subject><issn>0732-183X</issn><issn>1527-7755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkE1PJCEQhsnGjY66P2APJhz8OPUIdNM0RzPxa2PiRZO9EZopRrS7GYF24r9fJj3RbOpAQj1vUTwI_aZkThkhl38Wj3MqJZ3LXJQL_gPNKGeiEILzPTQjomQFbcq_B-gwxldCaNWUfB_t00ZwRuUMpft-7UPSgwHsLW79ALjXIfgNNp_Jr2CA5AyGD92NOjk_4BasD4D1mHznV36M_4VS0ENcd3pIE51ZfOeXqzc3XES8dBF0hGP00-ouwq_deYSeb66fFnfFw-Pt_eLqoTAl56mooLZ1K6UEKYUQbQNWQslKQ7hsy6qRYCvOzZLWoCXLl7XWDKCxljWUU1MeofNp7jr49xFiUr2LBrq8HuTFlcghUjGeQTqBJvgYA1i1Di7_6FNRoramVTattqaVzLU1nTMnu-Fj28PyOzGpzf3TXV9HozubxRgXvzBOGkFqkbGzCXtxq5eNC6Bir7suD2Xq1fiv5_4B8qaV6w</recordid><startdate>19910901</startdate><enddate>19910901</enddate><creator>CHAO, N. J</creator><creator>NADEMANEE, A. P</creator><creator>LONG, G. D</creator><creator>SCHMIDT, G. 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J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Importance of bone marrow cytogenetic evaluation before autologous bone marrow transplantation for Hodgkin's disease</atitle><jtitle>Journal of clinical oncology</jtitle><addtitle>J Clin Oncol</addtitle><date>1991-09-01</date><risdate>1991</risdate><volume>9</volume><issue>9</issue><spage>1575</spage><epage>1579</epage><pages>1575-1579</pages><issn>0732-183X</issn><eissn>1527-7755</eissn><abstract>Alkylating agents used either with or without radiation therapy have been associated with the development of myelodysplastic syndrome (MDS) and acute nonlymphoblastic leukemia (ANLL) after treatment of both malignant and nonmalignant disorders. This report describes seven patients with recurrent Hodgkin's disease (HD) evaluated for bone marrow transplantation (BMT) who developed chromosomal abnormalities, and emphasizes the importance of bone marrow cytogenetic studies before bone marrow harvest. Three patients with histologically normal bone marrow underwent autologous BMT and subsequently developed an MDS or ANLL. Four patients had the clonal abnormality detected before bone marrow harvest and did not proceed to BMT.</abstract><cop>Baltimore, MD</cop><pub>American Society of Clinical Oncology</pub><pmid>1875219</pmid><doi>10.1200/JCO.1991.9.9.1575</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0732-183X |
| ispartof | Journal of clinical oncology, 1991-09, Vol.9 (9), p.1575-1579 |
| issn | 0732-183X 1527-7755 |
| language | eng |
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| source | MEDLINE; American Society of Clinical Oncology Online Journals; Journals@Ovid Complete |
| subjects | Adult Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Bone Marrow - ultrastructure Bone Marrow Transplantation Bone marrow, stem cells transplantation. Graft versus host reaction Chromosome Aberrations Female Hodgkin Disease - genetics Hodgkin Disease - surgery Humans Male Medical sciences Middle Aged Transfusions. Complications. Transfusion reactions. Cell and gene therapy Translocation, Genetic Transplantation, Homologous |
| title | Importance of bone marrow cytogenetic evaluation before autologous bone marrow transplantation for Hodgkin's disease |
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