Effects of agonists of peroxisome proliferator-activated receptor γ on proteoglycan degradation and matrix metalloproteinase production in rat cartilage in vitro

Objective To examine the effects of agonists of peroxisome proliferator-activated receptor (PPAR) γ on proteoglycan degradation induced by interleukin (IL)-1β or tumor necrosis factor (TNF)α in cartilage in vitro. Design Proteoglycan degradation was measured as release of radioactivity from rat cart...

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Veröffentlicht in:	Osteoarthritis and cartilage 2002-09, Vol.10 (9), p.673-679
Hauptverfasser:	Sabatini, M., Bardiot, A., Lesur, C., Moulharat, N., Thomas, M., Richard, I., Fradin, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cartilage - metabolism Cells, Cultured Chondrocytes - drug effects Chondrocytes - metabolism Endopeptidases - metabolism Fluorometry Interleukin-1 - pharmacology Male Matrix Metalloproteinases - biosynthesis PPAR, MMP, Aggrecanase, IL-1, TNF Proteoglycans - metabolism Rats Rats, Wistar Receptors, Cytoplasmic and Nuclear - agonists Transcription Factors - agonists Tumor Necrosis Factor-alpha - pharmacology
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