Modulation by citrate of glycolytic oscillations in skeletal muscle extracts
Oscillatory behavior of glycolysis in cell-free extracts of skeletal muscle involves repeated bursts of phosphofructokinase activity and associated oscillations in the [ATP]/[ADP] ratio. Addition of citrate, a potent physiological inhibitor of phosphofructokinase, decreased the frequency of the osci...
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| Veröffentlicht in: | The Journal of biological chemistry 1991-08, Vol.266 (24), p.15675-15678 |
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| creator | TORNHEIM, K ANDRES, V SCHULTZ, V |
| description | Oscillatory behavior of glycolysis in cell-free extracts of skeletal muscle involves repeated bursts of phosphofructokinase
activity and associated oscillations in the [ATP]/[ADP] ratio. Addition of citrate, a potent physiological inhibitor of phosphofructokinase,
decreased the frequency of the oscillations and delayed the first burst of phosphofructokinase activity in a dose-dependent
manner. Citrate decreased the trigger point [ATP]/[ADP] ratio at which bursts of phosphofructokinase activity were initiated
but had a much smaller effect on the average [ATP]/[ADP] ratio and did not decrease the peak values of the ratio. When oscillations
were prevented by addition of fructose-2,6-P2, the decrease in the [ATP]/[ADP] ratio caused by citrate in the steady state
system was similar to the decrease in the trigger point [ATP]/[ADP] ratio in the oscillatory system. The decrease in the average
[ATP]/[ADP] ratio was greater in the steady state system than in the oscillating system. These results demonstrate advantages
of oscillatory behavior of glycolysis in the regulation of carbohydrate utilization and the maintenance of a high [ATP]/[ADP]
ratio. |
| doi_str_mv | 10.1016/S0021-9258(18)98460-7 |
| format | Article |
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activity and associated oscillations in the [ATP]/[ADP] ratio. Addition of citrate, a potent physiological inhibitor of phosphofructokinase,
decreased the frequency of the oscillations and delayed the first burst of phosphofructokinase activity in a dose-dependent
manner. Citrate decreased the trigger point [ATP]/[ADP] ratio at which bursts of phosphofructokinase activity were initiated
but had a much smaller effect on the average [ATP]/[ADP] ratio and did not decrease the peak values of the ratio. When oscillations
were prevented by addition of fructose-2,6-P2, the decrease in the [ATP]/[ADP] ratio caused by citrate in the steady state
system was similar to the decrease in the trigger point [ATP]/[ADP] ratio in the oscillatory system. The decrease in the average
[ATP]/[ADP] ratio was greater in the steady state system than in the oscillating system. These results demonstrate advantages
of oscillatory behavior of glycolysis in the regulation of carbohydrate utilization and the maintenance of a high [ATP]/[ADP]
ratio.</description><identifier>ISSN: 0021-9258</identifier><identifier>EISSN: 1083-351X</identifier><identifier>DOI: 10.1016/S0021-9258(18)98460-7</identifier><identifier>PMID: 1831450</identifier><identifier>CODEN: JBCHA3</identifier><language>eng</language><publisher>Bethesda, MD: American Society for Biochemistry and Molecular Biology</publisher><subject>Adenosine Diphosphate - metabolism ; Adenosine Triphosphate - metabolism ; Animals ; Biological and medical sciences ; Calcium - metabolism ; Cell metabolism, cell oxidation ; Cell physiology ; Citrates - pharmacology ; Citric Acid ; effects on ; Fundamental and applied biological sciences. Psychology ; Glycolysis ; Male ; Molecular and cellular biology ; Muscles - drug effects ; Muscles - enzymology ; Muscles - metabolism ; oscillations ; Phosphofructokinase-1 - antagonists & inhibitors ; Phosphofructokinase-1 - metabolism ; Rats ; Rats, Inbred Strains ; skeletal muscle</subject><ispartof>The Journal of biological chemistry, 1991-08, Vol.266 (24), p.15675-15678</ispartof><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-cbea4a3b5c3173ac90ffd0e622aa9e8fb151f17c168c01b498f65e43cbaf3d353</citedby><cites>FETCH-LOGICAL-c440t-cbea4a3b5c3173ac90ffd0e622aa9e8fb151f17c168c01b498f65e43cbaf3d353</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5021904$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1831450$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TORNHEIM, K</creatorcontrib><creatorcontrib>ANDRES, V</creatorcontrib><creatorcontrib>SCHULTZ, V</creatorcontrib><title>Modulation by citrate of glycolytic oscillations in skeletal muscle extracts</title><title>The Journal of biological chemistry</title><addtitle>J Biol Chem</addtitle><description>Oscillatory behavior of glycolysis in cell-free extracts of skeletal muscle involves repeated bursts of phosphofructokinase
activity and associated oscillations in the [ATP]/[ADP] ratio. Addition of citrate, a potent physiological inhibitor of phosphofructokinase,
decreased the frequency of the oscillations and delayed the first burst of phosphofructokinase activity in a dose-dependent
manner. Citrate decreased the trigger point [ATP]/[ADP] ratio at which bursts of phosphofructokinase activity were initiated
but had a much smaller effect on the average [ATP]/[ADP] ratio and did not decrease the peak values of the ratio. When oscillations
were prevented by addition of fructose-2,6-P2, the decrease in the [ATP]/[ADP] ratio caused by citrate in the steady state
system was similar to the decrease in the trigger point [ATP]/[ADP] ratio in the oscillatory system. The decrease in the average
[ATP]/[ADP] ratio was greater in the steady state system than in the oscillating system. These results demonstrate advantages
of oscillatory behavior of glycolysis in the regulation of carbohydrate utilization and the maintenance of a high [ATP]/[ADP]
ratio.</description><subject>Adenosine Diphosphate - metabolism</subject><subject>Adenosine Triphosphate - metabolism</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Calcium - metabolism</subject><subject>Cell metabolism, cell oxidation</subject><subject>Cell physiology</subject><subject>Citrates - pharmacology</subject><subject>Citric Acid</subject><subject>effects on</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glycolysis</subject><subject>Male</subject><subject>Molecular and cellular biology</subject><subject>Muscles - drug effects</subject><subject>Muscles - enzymology</subject><subject>Muscles - metabolism</subject><subject>oscillations</subject><subject>Phosphofructokinase-1 - antagonists & inhibitors</subject><subject>Phosphofructokinase-1 - metabolism</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>skeletal muscle</subject><issn>0021-9258</issn><issn>1083-351X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhq0KVLYfP6GSDwjRQ8ATf8Q5oooWpEUcaKXeLGd23DU46xIngv33ZLur9shcfJjnfcd6GLsA8QEEmI8_hKihamtt34O9bK0yomqO2AKElZXUcP-KLZ6RN-yklJ9iHtXCMTsGK0FpsWDLb3k1JT_GvOHdlmMcBz8Sz4E_pC3mtB0j8lwwpj1UeNzw8osSjT7xfiqYiNPfOYVjOWOvg0-Fzg_vKbu7_nx79aVafr_5evVpWaFSYqywI6-87DRKaKTHVoSwEmTq2vuWbOhAQ4AGwVgU0KnWBqNJSex8kCup5Sl7t-99HPLvicro-liQ5i9uKE_FNbVQSjfyvyAYo2xjdo16D-KQSxkouMch9n7YOhBup9s96XY7lw6se9Ltmjl3cTgwdT2tXlJ7v_P-7WHvC_oUBr_BWJ4xPXe2Qr1g6_iw_hMHcl3MuKbe1ca4WjnQptHyH_DnlK8</recordid><startdate>19910825</startdate><enddate>19910825</enddate><creator>TORNHEIM, K</creator><creator>ANDRES, V</creator><creator>SCHULTZ, V</creator><general>American Society for Biochemistry and Molecular Biology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>M81</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19910825</creationdate><title>Modulation by citrate of glycolytic oscillations in skeletal muscle extracts</title><author>TORNHEIM, K ; ANDRES, V ; SCHULTZ, V</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c440t-cbea4a3b5c3173ac90ffd0e622aa9e8fb151f17c168c01b498f65e43cbaf3d353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Adenosine Diphosphate - metabolism</topic><topic>Adenosine Triphosphate - metabolism</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Calcium - metabolism</topic><topic>Cell metabolism, cell oxidation</topic><topic>Cell physiology</topic><topic>Citrates - pharmacology</topic><topic>Citric Acid</topic><topic>effects on</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glycolysis</topic><topic>Male</topic><topic>Molecular and cellular biology</topic><topic>Muscles - drug effects</topic><topic>Muscles - enzymology</topic><topic>Muscles - metabolism</topic><topic>oscillations</topic><topic>Phosphofructokinase-1 - antagonists & inhibitors</topic><topic>Phosphofructokinase-1 - metabolism</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>skeletal muscle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TORNHEIM, K</creatorcontrib><creatorcontrib>ANDRES, V</creatorcontrib><creatorcontrib>SCHULTZ, V</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 3</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of biological chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TORNHEIM, K</au><au>ANDRES, V</au><au>SCHULTZ, V</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Modulation by citrate of glycolytic oscillations in skeletal muscle extracts</atitle><jtitle>The Journal of biological chemistry</jtitle><addtitle>J Biol Chem</addtitle><date>1991-08-25</date><risdate>1991</risdate><volume>266</volume><issue>24</issue><spage>15675</spage><epage>15678</epage><pages>15675-15678</pages><issn>0021-9258</issn><eissn>1083-351X</eissn><coden>JBCHA3</coden><abstract>Oscillatory behavior of glycolysis in cell-free extracts of skeletal muscle involves repeated bursts of phosphofructokinase
activity and associated oscillations in the [ATP]/[ADP] ratio. Addition of citrate, a potent physiological inhibitor of phosphofructokinase,
decreased the frequency of the oscillations and delayed the first burst of phosphofructokinase activity in a dose-dependent
manner. Citrate decreased the trigger point [ATP]/[ADP] ratio at which bursts of phosphofructokinase activity were initiated
but had a much smaller effect on the average [ATP]/[ADP] ratio and did not decrease the peak values of the ratio. When oscillations
were prevented by addition of fructose-2,6-P2, the decrease in the [ATP]/[ADP] ratio caused by citrate in the steady state
system was similar to the decrease in the trigger point [ATP]/[ADP] ratio in the oscillatory system. The decrease in the average
[ATP]/[ADP] ratio was greater in the steady state system than in the oscillating system. These results demonstrate advantages
of oscillatory behavior of glycolysis in the regulation of carbohydrate utilization and the maintenance of a high [ATP]/[ADP]
ratio.</abstract><cop>Bethesda, MD</cop><pub>American Society for Biochemistry and Molecular Biology</pub><pmid>1831450</pmid><doi>10.1016/S0021-9258(18)98460-7</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adenosine Diphosphate - metabolism Adenosine Triphosphate - metabolism Animals Biological and medical sciences Calcium - metabolism Cell metabolism, cell oxidation Cell physiology Citrates - pharmacology Citric Acid effects on Fundamental and applied biological sciences. Psychology Glycolysis Male Molecular and cellular biology Muscles - drug effects Muscles - enzymology Muscles - metabolism oscillations Phosphofructokinase-1 - antagonists & inhibitors Phosphofructokinase-1 - metabolism Rats Rats, Inbred Strains skeletal muscle |
| title | Modulation by citrate of glycolytic oscillations in skeletal muscle extracts |
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