Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling

Target of Rapamycin (TOR) mediates a signalling pathway that couples amino acid availability to S6 kinase (S6K) activation, translational initiation and cell growth. Here, we show that tuberous sclerosis 1 (Tsc1) and Tsc2, tumour suppressors that are responsible for the tuberous sclerosis syndrome,...

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Veröffentlicht in:	Nature cell biology 2002-09, Vol.4 (9), p.699-704
Hauptverfasser:	Pan, Duojia, Gao, Xinsheng, Zhang, Yong, Arrazola, Peter, Hino, Okio, Kobayashi, Toshiyuki, Yeung, Raymond S, Ru, Binggeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Amino Acids - metabolism Animals Biomedical and Life Sciences brief-communication Cancer Research Cell Biology Cell growth Cell Line Cellular proteins Cellular signal transduction Cloning Developmental Biology Drosophila melanogaster - genetics Drosophila melanogaster - growth & development Drosophila melanogaster - metabolism Drosophila Proteins Genes, Insect Genes, Tumor Suppressor Genetic aspects Growth factors Humans Identification and classification Insect Proteins - genetics Insect Proteins - metabolism Insects Insulin Kinases Life Sciences Mammals Mutation Nutrients Phosphatidylinositol 3-Kinases Phosphotransferases (Alcohol Group Acceptor) - genetics Phosphotransferases (Alcohol Group Acceptor) - metabolism Physiological aspects Protein Kinases - genetics Protein Kinases - metabolism Proteins Proteins - genetics Proteins - metabolism Repressor Proteins - genetics Repressor Proteins - metabolism Ribosomal Protein S6 Kinases - metabolism Signal Transduction Sirolimus - pharmacology Stem Cells TOR Serine-Threonine Kinases Tumor suppressor genes Tumor Suppressor Proteins Tumors Upstream
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