Blockade of the ATP-Sensitive Potassium Channel Modulates Reactive Hyperemia in the Canine Coronary Circulation

The mechanism of reactive hyperemia remains unknown. We hypothesized that reactive hyperemia was related to the opening of ATP-sensitive potassium channels during coronary occlusion. The resulting hyperpolarization of the smooth muscle cell plasma membrane might reduce calcium influx through voltage...

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Veröffentlicht in:	Circulation research 1991-09, Vol.69 (3), p.618-622
Hauptverfasser:	Aversano, Thomas, Ouyang, Pamela, Silverman, Howard
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - pharmacology Adenosine - pharmacology Adenosine Triphosphate - physiology Animals ATP Biological and medical sciences Calcium Channels - drug effects Coronary Circulation Dogs Fundamental and applied biological sciences. Psychology General aspects glibenclamide Glyburide - pharmacology Hyperemia - physiopathology In Vitro Techniques membrane potential potassium Potassium Channels - drug effects Vertebrates: cardiovascular system
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