Detection of brain-derived neurotrophic factor-like activity in fibroblasts and Schwann cells: Inhibition by antibodies to NGF

mRNA coding for brain-derived neurotrophic factor (BDNF) has been detected in cultured L929 fibroblasts, rat dermal fibroblasts, and sciatic nerve Schwann cells, as well as in rat skin. Medium conditioned by cultured fibroblasts and Schwann cells also stimulates neurite growth from retinal explants...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 1991-08, Vol.7 (2), p.265-275
Hauptverfasser:	Acheson, Ann, Barker, Philip A., Alderson, Ralph F., Miller, Freda D., Murphy, Richard A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies - immunology Antibodies - pharmacology Axons - drug effects Axons - physiology Biological and medical sciences Blotting, Western Brain - metabolism Brain-Derived Neurotrophic Factor Cell Survival - drug effects Cells, Cultured Chick Embryo Culture Media - pharmacology Fibroblasts - metabolism Fundamental and applied biological sciences. Psychology Metabolisms and neurohumoral controls Mice Nerve Growth Factors - immunology Nerve Tissue Proteins - genetics Nerve Tissue Proteins - immunology Nerve Tissue Proteins - metabolism Neurons, Afferent - drug effects Nitrogen metabolism. Proteins. Glycoproteins. Nucleic acids. Collagen Rats RNA, Messenger - genetics RNA, Messenger - metabolism Schwann Cells - metabolism Vertebrates: anatomy and physiology, studies on body, several organs or systems
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