Toxoplasma gondii eukaryotic translation initiation factor 4A associated with tachyzoite virulence is down-regulated in the bradyzoite stage

Comparative proteome analysis of mouse-virulent and attenuated Toxoplasma gondii strain revealed that steady-state synthesis of an unknown 53 kDa protein is markedly reduced in attenuated parasites. The results from protein microsequencing allowed isolation of a single-copy gene encoding a T. gondii...

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Veröffentlicht in:	International journal for parasitology 2002-09, Vol.32 (10), p.1225-1234
Hauptverfasser:	GASTENS, Martin H, FISCHER, Hans-Georg
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Biological and medical sciences Cells, Cultured Cloning, Molecular Down-Regulation Electrophoresis, Gel, Two-Dimensional - methods Eukaryotic Initiation Factor-4A - analysis Eukaryotic Initiation Factor-4A - genetics Eukaryotic Initiation Factor-4A - metabolism Fundamental and applied biological sciences. Psychology Gene Expression Regulation Genes, Protozoan Life Cycle Stages Life cycle. Host-agent relationship. Pathogenesis Mice Models, Genetic Molecular Sequence Data Protozoa Protozoan Proteins - genetics Protozoan Proteins - metabolism Sequence Alignment Species Specificity Toxoplasma - genetics Toxoplasma - growth & development Toxoplasma - pathogenicity Virulence
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