Definition of the first mannosylation step in phosphatidylinositol mannoside synthesis. PimA is essential for growth of mycobacteria

We examined the function of the pimA (Rv2610c) gene, located in the vicinity of the phosphatidylinositol synthase gene in the genomes of Mycobacterium tuberculosis and Mycobacterium smegmatis, which encodes a putative mannosyltransferase involved in the early steps of phosphatidylinositol mannoside...

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Veröffentlicht in:	The Journal of biological chemistry 2002-08, Vol.277 (35), p.31335-31344
Hauptverfasser:	Korduláková, Jana, Gilleron, Martine, Mikusova, Katarína, Puzo, Germain, Brennan, Patrick J, Gicquel, Brigitte, Jackson, Mary
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell-Free System Dolichol Monophosphate Mannose - chemistry Dolichol Monophosphate Mannose - metabolism Gene Expression Regulation, Bacterial Genes, Essential Genome, Bacterial Glycosylation Kinetics Mannose - metabolism Mycobacterium smegmatis - genetics Mycobacterium tuberculosis - genetics Phosphatidylinositols - biosynthesis
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