Preoperative radiation therapy followed by extrafascial hysterectomy in patients with stage II endometrial carcinoma

Seventy‐four patients with Stage II endometrial cancer were treated by a combination of preoperative radiation therapy followed by extrafascial hysterectomy, bilateral salpingo‐oophorectomy, and paraaortic lymph node sampling at the University of Kentucky Medical Center from 1967 to 1988. All patien...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Cancer 1991-09, Vol.68 (6), p.1261-1264
Hauptverfasser: Higgins, R. V., van Nagell, J. R., Horn, E. J., Roberts, S. L., Donaldson, E. S., Gallion, H. H., Depriest, P. D., Powell, D. E., Kryscio, R. J.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 1264
container_issue 6
container_start_page 1261
container_title Cancer
container_volume 68
creator Higgins, R. V.
van Nagell, J. R.
Horn, E. J.
Roberts, S. L.
Donaldson, E. S.
Gallion, H. H.
Depriest, P. D.
Powell, D. E.
Kryscio, R. J.
description Seventy‐four patients with Stage II endometrial cancer were treated by a combination of preoperative radiation therapy followed by extrafascial hysterectomy, bilateral salpingo‐oophorectomy, and paraaortic lymph node sampling at the University of Kentucky Medical Center from 1967 to 1988. All patients had histologically confirmed endometrial cancer with involvement of the endocervix. The cell types and numbers of the tumors treated were as follows: adenocarcinoma, 58; adenoacanthoma, six; adenosquamous carcinoma, nine; and clear cell carcinoma, one. Preoperative radiation consisted of 4500 cGy external therapy followed by one intracavitary implant providing an additional 2000 cGy to point A. Surgery was done 4 to 6 weeks after completion of radiation therapy. Five patients (7.1%) had paraaortic lymph node metastases. Four were treated with extended‐field radiation therapy and one with platinum‐based combination chemotherapy. After treatment, the patients were followed at regular intervals from 2 to 22 years (mean, 5.4 years). Eleven patients (15%) had recurrent cancer, with the vagina and upper abdomen being the most common sites of spread. The estimated 5‐year and 10‐year disease‐free survival rates of these patients are 88% and 76%, respectively. Cell type, depth of myometrial invasion, and lymph node status were the most important prognostic variables in the patients evaluated. These data confirm that the combination of preoperative radiation therapy and surgery produces excellent long‐term survival in patients with Stage II endometrial cancer.
doi_str_mv 10.1002/1097-0142(19910915)68:6<1261::AID-CNCR2820680614>3.0.CO;2-V
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72042420</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>72042420</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4984-cadd65f4c8c2e224d369e3aed14601f7cb31926bb4087c9518c484fda36e4a133</originalsourceid><addsrcrecordid>eNqVUVuL1DAUDqKs4-pPEPIgog8dc2uajiIs9TawOCK6CD6ETHrqRNqmJhnH_ntbZlzRB8Gn5Jzvwsf5EKooWVJC2BNKyiIjVLBHtCyngeaPpVrJZ5RJulpdrF9k1dvqPVOMSEUkFc_5kiyrzVOWXd1Ai2v1TbQghKgsF_zTbXQnxq_TWLCcn6EzqgpeFOUCpXcB_ADBJPcdcDC1m36-x2k37YYRN75t_QFqvB0x_EjBNCZaZ1q8G2OCADb5bsSux8Okgz5FfHBph2MyXwCv1xj62neQwiyxJljX-87cRbca00a4d3rP0cdXLz9Ub7LLzet1dXGZWVEqkVlT1zJvhFWWAWOi5rIEbqCmQhLaFHbLacnkdiuIKmyZU2WFEk1tuARhKOfn6OHRdwj-2x5i0p2LFtrW9OD3UReMCCYYmYifj0QbfIwBGj0E15kwakr03Imer6rnq-pfnWiptNRzJ1pPneg_O9FcE11tNNNXk_v9U4z9toP6t_exhAl_cMKn25q2Caa3Ll7ThJCUlTOtOdIOroXx_xL-M-BfCP8JZna5BQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72042420</pqid></control><display><type>article</type><title>Preoperative radiation therapy followed by extrafascial hysterectomy in patients with stage II endometrial carcinoma</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Higgins, R. V. ; van Nagell, J. R. ; Horn, E. J. ; Roberts, S. L. ; Donaldson, E. S. ; Gallion, H. H. ; Depriest, P. D. ; Powell, D. E. ; Kryscio, R. J.</creator><creatorcontrib>Higgins, R. V. ; van Nagell, J. R. ; Horn, E. J. ; Roberts, S. L. ; Donaldson, E. S. ; Gallion, H. H. ; Depriest, P. D. ; Powell, D. E. ; Kryscio, R. J.</creatorcontrib><description>Seventy‐four patients with Stage II endometrial cancer were treated by a combination of preoperative radiation therapy followed by extrafascial hysterectomy, bilateral salpingo‐oophorectomy, and paraaortic lymph node sampling at the University of Kentucky Medical Center from 1967 to 1988. All patients had histologically confirmed endometrial cancer with involvement of the endocervix. The cell types and numbers of the tumors treated were as follows: adenocarcinoma, 58; adenoacanthoma, six; adenosquamous carcinoma, nine; and clear cell carcinoma, one. Preoperative radiation consisted of 4500 cGy external therapy followed by one intracavitary implant providing an additional 2000 cGy to point A. Surgery was done 4 to 6 weeks after completion of radiation therapy. Five patients (7.1%) had paraaortic lymph node metastases. Four were treated with extended‐field radiation therapy and one with platinum‐based combination chemotherapy. After treatment, the patients were followed at regular intervals from 2 to 22 years (mean, 5.4 years). Eleven patients (15%) had recurrent cancer, with the vagina and upper abdomen being the most common sites of spread. The estimated 5‐year and 10‐year disease‐free survival rates of these patients are 88% and 76%, respectively. Cell type, depth of myometrial invasion, and lymph node status were the most important prognostic variables in the patients evaluated. These data confirm that the combination of preoperative radiation therapy and surgery produces excellent long‐term survival in patients with Stage II endometrial cancer.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/1097-0142(19910915)68:6&lt;1261::AID-CNCR2820680614&gt;3.0.CO;2-V</identifier><identifier>PMID: 1873779</identifier><identifier>CODEN: CANCAR</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adenocarcinoma - mortality ; Adenocarcinoma - pathology ; Adenocarcinoma - secondary ; Adenocarcinoma - therapy ; Adult ; Aged ; Aged, 80 and over ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Biological and medical sciences ; Carcinoma, Squamous Cell - mortality ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - secondary ; Carcinoma, Squamous Cell - therapy ; Combined Modality Therapy ; Female ; Humans ; Hysterectomy ; Lymphatic Metastasis ; Medical sciences ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Recurrence, Local ; Neoplasm Staging ; Ovariectomy ; Radiotherapy Dosage ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the genital tract and mammary gland ; Survival Rate ; Uterine Cervical Neoplasms - mortality ; Uterine Cervical Neoplasms - pathology ; Uterine Cervical Neoplasms - therapy</subject><ispartof>Cancer, 1991-09, Vol.68 (6), p.1261-1264</ispartof><rights>Copyright © 1991 American Cancer Society</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4984-cadd65f4c8c2e224d369e3aed14601f7cb31926bb4087c9518c484fda36e4a133</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=4461299$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1873779$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Higgins, R. V.</creatorcontrib><creatorcontrib>van Nagell, J. R.</creatorcontrib><creatorcontrib>Horn, E. J.</creatorcontrib><creatorcontrib>Roberts, S. L.</creatorcontrib><creatorcontrib>Donaldson, E. S.</creatorcontrib><creatorcontrib>Gallion, H. H.</creatorcontrib><creatorcontrib>Depriest, P. D.</creatorcontrib><creatorcontrib>Powell, D. E.</creatorcontrib><creatorcontrib>Kryscio, R. J.</creatorcontrib><title>Preoperative radiation therapy followed by extrafascial hysterectomy in patients with stage II endometrial carcinoma</title><title>Cancer</title><addtitle>Cancer</addtitle><description>Seventy‐four patients with Stage II endometrial cancer were treated by a combination of preoperative radiation therapy followed by extrafascial hysterectomy, bilateral salpingo‐oophorectomy, and paraaortic lymph node sampling at the University of Kentucky Medical Center from 1967 to 1988. All patients had histologically confirmed endometrial cancer with involvement of the endocervix. The cell types and numbers of the tumors treated were as follows: adenocarcinoma, 58; adenoacanthoma, six; adenosquamous carcinoma, nine; and clear cell carcinoma, one. Preoperative radiation consisted of 4500 cGy external therapy followed by one intracavitary implant providing an additional 2000 cGy to point A. Surgery was done 4 to 6 weeks after completion of radiation therapy. Five patients (7.1%) had paraaortic lymph node metastases. Four were treated with extended‐field radiation therapy and one with platinum‐based combination chemotherapy. After treatment, the patients were followed at regular intervals from 2 to 22 years (mean, 5.4 years). Eleven patients (15%) had recurrent cancer, with the vagina and upper abdomen being the most common sites of spread. The estimated 5‐year and 10‐year disease‐free survival rates of these patients are 88% and 76%, respectively. Cell type, depth of myometrial invasion, and lymph node status were the most important prognostic variables in the patients evaluated. These data confirm that the combination of preoperative radiation therapy and surgery produces excellent long‐term survival in patients with Stage II endometrial cancer.</description><subject>Adenocarcinoma - mortality</subject><subject>Adenocarcinoma - pathology</subject><subject>Adenocarcinoma - secondary</subject><subject>Adenocarcinoma - therapy</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Squamous Cell - mortality</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carcinoma, Squamous Cell - secondary</subject><subject>Carcinoma, Squamous Cell - therapy</subject><subject>Combined Modality Therapy</subject><subject>Female</subject><subject>Humans</subject><subject>Hysterectomy</subject><subject>Lymphatic Metastasis</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Recurrence, Local</subject><subject>Neoplasm Staging</subject><subject>Ovariectomy</subject><subject>Radiotherapy Dosage</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the genital tract and mammary gland</subject><subject>Survival Rate</subject><subject>Uterine Cervical Neoplasms - mortality</subject><subject>Uterine Cervical Neoplasms - pathology</subject><subject>Uterine Cervical Neoplasms - therapy</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVUVuL1DAUDqKs4-pPEPIgog8dc2uajiIs9TawOCK6CD6ETHrqRNqmJhnH_ntbZlzRB8Gn5Jzvwsf5EKooWVJC2BNKyiIjVLBHtCyngeaPpVrJZ5RJulpdrF9k1dvqPVOMSEUkFc_5kiyrzVOWXd1Ai2v1TbQghKgsF_zTbXQnxq_TWLCcn6EzqgpeFOUCpXcB_ADBJPcdcDC1m36-x2k37YYRN75t_QFqvB0x_EjBNCZaZ1q8G2OCADb5bsSux8Okgz5FfHBph2MyXwCv1xj62neQwiyxJljX-87cRbca00a4d3rP0cdXLz9Ub7LLzet1dXGZWVEqkVlT1zJvhFWWAWOi5rIEbqCmQhLaFHbLacnkdiuIKmyZU2WFEk1tuARhKOfn6OHRdwj-2x5i0p2LFtrW9OD3UReMCCYYmYifj0QbfIwBGj0E15kwakr03Imer6rnq-pfnWiptNRzJ1pPneg_O9FcE11tNNNXk_v9U4z9toP6t_exhAl_cMKn25q2Caa3Ll7ThJCUlTOtOdIOroXx_xL-M-BfCP8JZna5BQ</recordid><startdate>19910915</startdate><enddate>19910915</enddate><creator>Higgins, R. V.</creator><creator>van Nagell, J. R.</creator><creator>Horn, E. J.</creator><creator>Roberts, S. L.</creator><creator>Donaldson, E. S.</creator><creator>Gallion, H. H.</creator><creator>Depriest, P. D.</creator><creator>Powell, D. E.</creator><creator>Kryscio, R. J.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19910915</creationdate><title>Preoperative radiation therapy followed by extrafascial hysterectomy in patients with stage II endometrial carcinoma</title><author>Higgins, R. V. ; van Nagell, J. R. ; Horn, E. J. ; Roberts, S. L. ; Donaldson, E. S. ; Gallion, H. H. ; Depriest, P. D. ; Powell, D. E. ; Kryscio, R. J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4984-cadd65f4c8c2e224d369e3aed14601f7cb31926bb4087c9518c484fda36e4a133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Adenocarcinoma - mortality</topic><topic>Adenocarcinoma - pathology</topic><topic>Adenocarcinoma - secondary</topic><topic>Adenocarcinoma - therapy</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Squamous Cell - mortality</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Carcinoma, Squamous Cell - secondary</topic><topic>Carcinoma, Squamous Cell - therapy</topic><topic>Combined Modality Therapy</topic><topic>Female</topic><topic>Humans</topic><topic>Hysterectomy</topic><topic>Lymphatic Metastasis</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Recurrence, Local</topic><topic>Neoplasm Staging</topic><topic>Ovariectomy</topic><topic>Radiotherapy Dosage</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the genital tract and mammary gland</topic><topic>Survival Rate</topic><topic>Uterine Cervical Neoplasms - mortality</topic><topic>Uterine Cervical Neoplasms - pathology</topic><topic>Uterine Cervical Neoplasms - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Higgins, R. V.</creatorcontrib><creatorcontrib>van Nagell, J. R.</creatorcontrib><creatorcontrib>Horn, E. J.</creatorcontrib><creatorcontrib>Roberts, S. L.</creatorcontrib><creatorcontrib>Donaldson, E. S.</creatorcontrib><creatorcontrib>Gallion, H. H.</creatorcontrib><creatorcontrib>Depriest, P. D.</creatorcontrib><creatorcontrib>Powell, D. E.</creatorcontrib><creatorcontrib>Kryscio, R. J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Higgins, R. V.</au><au>van Nagell, J. R.</au><au>Horn, E. J.</au><au>Roberts, S. L.</au><au>Donaldson, E. S.</au><au>Gallion, H. H.</au><au>Depriest, P. D.</au><au>Powell, D. E.</au><au>Kryscio, R. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preoperative radiation therapy followed by extrafascial hysterectomy in patients with stage II endometrial carcinoma</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>1991-09-15</date><risdate>1991</risdate><volume>68</volume><issue>6</issue><spage>1261</spage><epage>1264</epage><pages>1261-1264</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><coden>CANCAR</coden><abstract>Seventy‐four patients with Stage II endometrial cancer were treated by a combination of preoperative radiation therapy followed by extrafascial hysterectomy, bilateral salpingo‐oophorectomy, and paraaortic lymph node sampling at the University of Kentucky Medical Center from 1967 to 1988. All patients had histologically confirmed endometrial cancer with involvement of the endocervix. The cell types and numbers of the tumors treated were as follows: adenocarcinoma, 58; adenoacanthoma, six; adenosquamous carcinoma, nine; and clear cell carcinoma, one. Preoperative radiation consisted of 4500 cGy external therapy followed by one intracavitary implant providing an additional 2000 cGy to point A. Surgery was done 4 to 6 weeks after completion of radiation therapy. Five patients (7.1%) had paraaortic lymph node metastases. Four were treated with extended‐field radiation therapy and one with platinum‐based combination chemotherapy. After treatment, the patients were followed at regular intervals from 2 to 22 years (mean, 5.4 years). Eleven patients (15%) had recurrent cancer, with the vagina and upper abdomen being the most common sites of spread. The estimated 5‐year and 10‐year disease‐free survival rates of these patients are 88% and 76%, respectively. Cell type, depth of myometrial invasion, and lymph node status were the most important prognostic variables in the patients evaluated. These data confirm that the combination of preoperative radiation therapy and surgery produces excellent long‐term survival in patients with Stage II endometrial cancer.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>1873779</pmid><doi>10.1002/1097-0142(19910915)68:6&lt;1261::AID-CNCR2820680614&gt;3.0.CO;2-V</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0008-543X
ispartof Cancer, 1991-09, Vol.68 (6), p.1261-1264
issn 0008-543X
1097-0142
language eng
recordid cdi_proquest_miscellaneous_72042420
source MEDLINE; Alma/SFX Local Collection
subjects Adenocarcinoma - mortality
Adenocarcinoma - pathology
Adenocarcinoma - secondary
Adenocarcinoma - therapy
Adult
Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Biological and medical sciences
Carcinoma, Squamous Cell - mortality
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - secondary
Carcinoma, Squamous Cell - therapy
Combined Modality Therapy
Female
Humans
Hysterectomy
Lymphatic Metastasis
Medical sciences
Middle Aged
Neoplasm Invasiveness
Neoplasm Recurrence, Local
Neoplasm Staging
Ovariectomy
Radiotherapy Dosage
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the genital tract and mammary gland
Survival Rate
Uterine Cervical Neoplasms - mortality
Uterine Cervical Neoplasms - pathology
Uterine Cervical Neoplasms - therapy
title Preoperative radiation therapy followed by extrafascial hysterectomy in patients with stage II endometrial carcinoma
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T10%3A32%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Preoperative%20radiation%20therapy%20followed%20by%20extrafascial%20hysterectomy%20in%20patients%20with%20stage%20II%20endometrial%20carcinoma&rft.jtitle=Cancer&rft.au=Higgins,%20R.%20V.&rft.date=1991-09-15&rft.volume=68&rft.issue=6&rft.spage=1261&rft.epage=1264&rft.pages=1261-1264&rft.issn=0008-543X&rft.eissn=1097-0142&rft.coden=CANCAR&rft_id=info:doi/10.1002/1097-0142(19910915)68:6%3C1261::AID-CNCR2820680614%3E3.0.CO;2-V&rft_dat=%3Cproquest_cross%3E72042420%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=72042420&rft_id=info:pmid/1873779&rfr_iscdi=true