Expression of cathepsins B, H, K, L, and S during human fetal lung development
Cathepsins are involved in lysosomal protein degradation, proenzyme activation, antigen processing, and hormone maturation. They are secreted by tumor cells and macrophages and catalyze the remodeling of extracellular matrix proteins. To gain insight into the expression pattern of cathepsins during...
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| Veröffentlicht in: | Developmental dynamics 2002-09, Vol.225 (1), p.14-21 |
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| container_title | Developmental dynamics |
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| creator | Bühling, F. Waldburg, N. Krüger, S. Röcken, C. Wiesner, O. Weber, E. Welte, T. |
| description | Cathepsins are involved in lysosomal protein degradation, proenzyme activation, antigen processing, and hormone maturation. They are secreted by tumor cells and macrophages and catalyze the remodeling of extracellular matrix proteins. To gain insight into the expression pattern of cathepsins during fetal lung development, the expression of cathepsins B, H, K, L, and S at protein and mRNA levels were evaluated by using immunohistochemistry and in situ hybridization. Early expression of cathepsins B, H, and K was found in epithelial cells of the branching presumptive bronchi (26th week of gestation), both cathepsin L and S immunoreactivities. A continuous decline in the proportion of cathepsin H‐positive interstitial CD68‐positive cells was observed. These discrete temporal and spatial variations in cathepsin expression during organogenesis of the human lung indicate different physiological roles for the individual enzymes in different cell types and developmental stages. © 2002 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/dvdy.10134 |
| format | Article |
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They are secreted by tumor cells and macrophages and catalyze the remodeling of extracellular matrix proteins. To gain insight into the expression pattern of cathepsins during fetal lung development, the expression of cathepsins B, H, K, L, and S at protein and mRNA levels were evaluated by using immunohistochemistry and in situ hybridization. Early expression of cathepsins B, H, and K was found in epithelial cells of the branching presumptive bronchi (<12th week of gestation). The most intense cathepsin K–specific immunoreactivity was found in developing airways with a lumen. Cathepsin K was found in epithelial cells only, whereas in contrast, cathepsins B and H were detected both in epithelial and interstitial cells. During fetal maturation, interstitial cells displayed cathepsin L immunoreactivity and, in the saccular phase (>26th week of gestation), both cathepsin L and S immunoreactivities. A continuous decline in the proportion of cathepsin H‐positive interstitial CD68‐positive cells was observed. These discrete temporal and spatial variations in cathepsin expression during organogenesis of the human lung indicate different physiological roles for the individual enzymes in different cell types and developmental stages. © 2002 Wiley‐Liss, Inc.</description><identifier>ISSN: 1058-8388</identifier><identifier>EISSN: 1097-0177</identifier><identifier>DOI: 10.1002/dvdy.10134</identifier><identifier>PMID: 12203716</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Antigens, CD - biosynthesis ; Antigens, Differentiation, Myelomonocytic - biosynthesis ; cathepsin ; Cathepsin B - biosynthesis ; Cathepsin H ; Cathepsin K ; Cathepsin L ; Cathepsins - biosynthesis ; Cysteine Endopeptidases - biosynthesis ; Female ; fetal development ; Gene Expression Regulation, Developmental ; Gestational Age ; human ; Humans ; Immunohistochemistry ; In Situ Hybridization ; Lung - embryology ; Lung - pathology ; Male ; RNA, Messenger - metabolism ; Time Factors</subject><ispartof>Developmental dynamics, 2002-09, Vol.225 (1), p.14-21</ispartof><rights>Copyright © 2002 Wiley‐Liss, Inc.</rights><rights>Copyright 2002 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3614-62d40c066a9bf0f1c30df31dd3714b7a51c80a95071019770ab77cb050b80d2e3</citedby><cites>FETCH-LOGICAL-c3614-62d40c066a9bf0f1c30df31dd3714b7a51c80a95071019770ab77cb050b80d2e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fdvdy.10134$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fdvdy.10134$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27903,27904,45553,45554,46387,46811</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12203716$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bühling, F.</creatorcontrib><creatorcontrib>Waldburg, N.</creatorcontrib><creatorcontrib>Krüger, S.</creatorcontrib><creatorcontrib>Röcken, C.</creatorcontrib><creatorcontrib>Wiesner, O.</creatorcontrib><creatorcontrib>Weber, E.</creatorcontrib><creatorcontrib>Welte, T.</creatorcontrib><title>Expression of cathepsins B, H, K, L, and S during human fetal lung development</title><title>Developmental dynamics</title><addtitle>Dev Dyn</addtitle><description>Cathepsins are involved in lysosomal protein degradation, proenzyme activation, antigen processing, and hormone maturation. They are secreted by tumor cells and macrophages and catalyze the remodeling of extracellular matrix proteins. To gain insight into the expression pattern of cathepsins during fetal lung development, the expression of cathepsins B, H, K, L, and S at protein and mRNA levels were evaluated by using immunohistochemistry and in situ hybridization. Early expression of cathepsins B, H, and K was found in epithelial cells of the branching presumptive bronchi (<12th week of gestation). The most intense cathepsin K–specific immunoreactivity was found in developing airways with a lumen. Cathepsin K was found in epithelial cells only, whereas in contrast, cathepsins B and H were detected both in epithelial and interstitial cells. During fetal maturation, interstitial cells displayed cathepsin L immunoreactivity and, in the saccular phase (>26th week of gestation), both cathepsin L and S immunoreactivities. A continuous decline in the proportion of cathepsin H‐positive interstitial CD68‐positive cells was observed. These discrete temporal and spatial variations in cathepsin expression during organogenesis of the human lung indicate different physiological roles for the individual enzymes in different cell types and developmental stages. © 2002 Wiley‐Liss, Inc.</description><subject>Antigens, CD - biosynthesis</subject><subject>Antigens, Differentiation, Myelomonocytic - biosynthesis</subject><subject>cathepsin</subject><subject>Cathepsin B - biosynthesis</subject><subject>Cathepsin H</subject><subject>Cathepsin K</subject><subject>Cathepsin L</subject><subject>Cathepsins - biosynthesis</subject><subject>Cysteine Endopeptidases - biosynthesis</subject><subject>Female</subject><subject>fetal development</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Gestational Age</subject><subject>human</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>In Situ Hybridization</subject><subject>Lung - embryology</subject><subject>Lung - pathology</subject><subject>Male</subject><subject>RNA, Messenger - metabolism</subject><subject>Time Factors</subject><issn>1058-8388</issn><issn>1097-0177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOwzAQRS0EoqWw4QOQVyxQAuM4iZ0ltOUhKljwkFhZju3QIOdBnBT696SkEjtWczU6upo5CB0TOCcAwYVe6XWfCA130JhAwnwgjO1ucsR9TjkfoQPnPgCAxyHZRyMSBEAZicfoYf5dN8a5vCpxlWEl26WpXV46fOXhWw_fe3jhYVlq_IR11-TlO152hSxxZlppse36hTYrY6u6MGV7iPYyaZ052s4JermeP09v_cXjzd30cuErGpPQjwMdgoI4lkmaQUYUBZ1RonV_VJgyGRHFQSYRsP6thDGQKWMqhQhSDjowdIJOh966qT4741pR5E4Za2Vpqs4JFkAICYUePBtA1VTONSYTdZMXslkLAmJjT2zsiV97PXyybe3Swug_dKurB8gAfOXWrP-pErPX2dtQ-gOMvnel</recordid><startdate>200209</startdate><enddate>200209</enddate><creator>Bühling, F.</creator><creator>Waldburg, N.</creator><creator>Krüger, S.</creator><creator>Röcken, C.</creator><creator>Wiesner, O.</creator><creator>Weber, E.</creator><creator>Welte, T.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200209</creationdate><title>Expression of cathepsins B, H, K, L, and S during human fetal lung development</title><author>Bühling, F. ; Waldburg, N. ; Krüger, S. ; Röcken, C. ; Wiesner, O. ; Weber, E. ; Welte, T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3614-62d40c066a9bf0f1c30df31dd3714b7a51c80a95071019770ab77cb050b80d2e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Antigens, CD - biosynthesis</topic><topic>Antigens, Differentiation, Myelomonocytic - biosynthesis</topic><topic>cathepsin</topic><topic>Cathepsin B - biosynthesis</topic><topic>Cathepsin H</topic><topic>Cathepsin K</topic><topic>Cathepsin L</topic><topic>Cathepsins - biosynthesis</topic><topic>Cysteine Endopeptidases - biosynthesis</topic><topic>Female</topic><topic>fetal development</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Gestational Age</topic><topic>human</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>In Situ Hybridization</topic><topic>Lung - embryology</topic><topic>Lung - pathology</topic><topic>Male</topic><topic>RNA, Messenger - metabolism</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bühling, F.</creatorcontrib><creatorcontrib>Waldburg, N.</creatorcontrib><creatorcontrib>Krüger, S.</creatorcontrib><creatorcontrib>Röcken, C.</creatorcontrib><creatorcontrib>Wiesner, O.</creatorcontrib><creatorcontrib>Weber, E.</creatorcontrib><creatorcontrib>Welte, T.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Developmental dynamics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bühling, F.</au><au>Waldburg, N.</au><au>Krüger, S.</au><au>Röcken, C.</au><au>Wiesner, O.</au><au>Weber, E.</au><au>Welte, T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of cathepsins B, H, K, L, and S during human fetal lung development</atitle><jtitle>Developmental dynamics</jtitle><addtitle>Dev Dyn</addtitle><date>2002-09</date><risdate>2002</risdate><volume>225</volume><issue>1</issue><spage>14</spage><epage>21</epage><pages>14-21</pages><issn>1058-8388</issn><eissn>1097-0177</eissn><abstract>Cathepsins are involved in lysosomal protein degradation, proenzyme activation, antigen processing, and hormone maturation. They are secreted by tumor cells and macrophages and catalyze the remodeling of extracellular matrix proteins. To gain insight into the expression pattern of cathepsins during fetal lung development, the expression of cathepsins B, H, K, L, and S at protein and mRNA levels were evaluated by using immunohistochemistry and in situ hybridization. Early expression of cathepsins B, H, and K was found in epithelial cells of the branching presumptive bronchi (<12th week of gestation). The most intense cathepsin K–specific immunoreactivity was found in developing airways with a lumen. Cathepsin K was found in epithelial cells only, whereas in contrast, cathepsins B and H were detected both in epithelial and interstitial cells. During fetal maturation, interstitial cells displayed cathepsin L immunoreactivity and, in the saccular phase (>26th week of gestation), both cathepsin L and S immunoreactivities. A continuous decline in the proportion of cathepsin H‐positive interstitial CD68‐positive cells was observed. These discrete temporal and spatial variations in cathepsin expression during organogenesis of the human lung indicate different physiological roles for the individual enzymes in different cell types and developmental stages. © 2002 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>12203716</pmid><doi>10.1002/dvdy.10134</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Antigens, CD - biosynthesis Antigens, Differentiation, Myelomonocytic - biosynthesis cathepsin Cathepsin B - biosynthesis Cathepsin H Cathepsin K Cathepsin L Cathepsins - biosynthesis Cysteine Endopeptidases - biosynthesis Female fetal development Gene Expression Regulation, Developmental Gestational Age human Humans Immunohistochemistry In Situ Hybridization Lung - embryology Lung - pathology Male RNA, Messenger - metabolism Time Factors |
| title | Expression of cathepsins B, H, K, L, and S during human fetal lung development |
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