Pluronic ® block copolymers for overcoming drug resistance in cancer

Pluronic ® block copolymers have been used extensively in a variety of pharmaceutical formulations including delivery of low molecular mass drugs and polypeptides. This review describes novel applications of Pluronic ® block copolymers in the treatment of drug-resistant tumors. It has been discovere...

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Veröffentlicht in:	Advanced drug delivery reviews 2002-09, Vol.54 (5), p.759-779
Hauptverfasser:	Kabanov, Alexander V, Batrakova, Elena V, Alakhov, Valery Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - antagonists & inhibitors Adenosine Triphosphate - metabolism Anthracyclines Antineoplastic Agents - administration & dosage ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors Block copolymer Cancer Doxorubicin - administration & dosage Drug Carriers Drug Resistance, Neoplasm Humans MDR Membrane Fluidity - drug effects MRP Multidrug resistant protein Neoplasms - drug therapy Neoplasms - metabolism Neoplasms - ultrastructure P-glycoprotein Poloxamer - chemistry Poloxamer - pharmacology
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