Structures of the Muraymycins, Novel Peptidoglycan Biosynthesis Inhibitors

The muraymycins, a family of nucleoside-lipopeptide antibiotics, were purified from the extract of Streptomyces sp. LL-AA896. The antibiotics were purified by chromatographic methods and characterized by NMR spectroscopy, degradation studies, and mass spectrometry. The structures of 19 compounds wer...

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Veröffentlicht in:	Journal of the American Chemical Society 2002-09, Vol.124 (35), p.10260-10261
Hauptverfasser:	McDonald, Leonard A, Barbieri, Laurel R, Carter, Guy T, Lenoy, Eileen, Lotvin, Jason, Petersen, Peter J, Siegel, Marshall M, Singh, Guy, Williamson, R. Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Biological and medical sciences Chromatography, High Pressure Liquid Fundamental and applied biological sciences. Psychology Molecular biophysics Peptidoglycan - biosynthesis Spectroscopy : techniques and spectras Streptomyces - chemistry Structure in molecular biology Structure-Activity Relationship Tridimensional structure Uracil - analogs & derivatives Uracil - chemistry Uracil - isolation & purification Uracil - pharmacology Urea - analogs & derivatives Urea - chemistry Urea - isolation & purification Urea - pharmacology
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