Prospective Evaluation of a Model of Prediction of Invasive Bacterial Infection Risk among Children with Cancer, Fever, and Neutropenia
A risk prediction model for invasive bacterial infection (IBI) was prospectively evaluated among children presenting with cancer, fever, and neutropenia. The model incorporated assessment of 5 previously identified risk factors: serum level of C-reactive protein (CRP) ⩾90 mg/L, hypotension, identifi...
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| Veröffentlicht in: | Clinical infectious diseases 2002-09, Vol.35 (6), p.678-683 |
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| creator | Santolaya, M. E. Alvarez, A. M. Avilés, C. L. Becker, A. Cofré, J. Enríquez, N. O'Ryan, M. Payá, E. Salgado, C. Silva, P. Tordecilla, J. Varas, M. Villarroel, M. Viviani, T. Zubieta, M. |
| description | A risk prediction model for invasive bacterial infection (IBI) was prospectively evaluated among children presenting with cancer, fever, and neutropenia. The model incorporated assessment of 5 previously identified risk factors: serum level of C-reactive protein (CRP) ⩾90 mg/L, hypotension, identification of relapse of leukemia as the cancer type, platelet count of ⩽50,000 platelets/mm3, and recent receipt of chemotherapy [16]. Children were uniformly evaluated at enrollment and were classified as having high or low risk for IBI according to a model that considers the number and type of variables present. Of the 263 febrile episodes evaluated during a 17-month period, 140 (53%) were in IBI-positive children. The sensitivity, specificity, and positive and negative predictive values of the model were 92%, 76%, 82%, and 90%, respectively. Identification of these 5 risk factors during the first 24 h of hospitalization was helpful in discriminating between children with a high or low risk for IBI. |
| doi_str_mv | 10.1086/342064 |
| format | Article |
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E. ; Alvarez, A. M. ; Avilés, C. L. ; Becker, A. ; Cofré, J. ; Enríquez, N. ; O'Ryan, M. ; Payá, E. ; Salgado, C. ; Silva, P. ; Tordecilla, J. ; Varas, M. ; Villarroel, M. ; Viviani, T. ; Zubieta, M.</creator><creatorcontrib>Santolaya, M. E. ; Alvarez, A. M. ; Avilés, C. L. ; Becker, A. ; Cofré, J. ; Enríquez, N. ; O'Ryan, M. ; Payá, E. ; Salgado, C. ; Silva, P. ; Tordecilla, J. ; Varas, M. ; Villarroel, M. ; Viviani, T. ; Zubieta, M.</creatorcontrib><description>A risk prediction model for invasive bacterial infection (IBI) was prospectively evaluated among children presenting with cancer, fever, and neutropenia. The model incorporated assessment of 5 previously identified risk factors: serum level of C-reactive protein (CRP) ⩾90 mg/L, hypotension, identification of relapse of leukemia as the cancer type, platelet count of ⩽50,000 platelets/mm3, and recent receipt of chemotherapy [16]. Children were uniformly evaluated at enrollment and were classified as having high or low risk for IBI according to a model that considers the number and type of variables present. Of the 263 febrile episodes evaluated during a 17-month period, 140 (53%) were in IBI-positive children. The sensitivity, specificity, and positive and negative predictive values of the model were 92%, 76%, 82%, and 90%, respectively. Identification of these 5 risk factors during the first 24 h of hospitalization was helpful in discriminating between children with a high or low risk for IBI.</description><identifier>ISSN: 1058-4838</identifier><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1086/342064</identifier><identifier>PMID: 12203164</identifier><identifier>CODEN: CIDIEL</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Adolescent ; Bacteremia ; Bacterial infections ; Bacterial Infections - epidemiology ; Bacterial Infections - etiology ; Biological and medical sciences ; Child ; Child health services ; Child, Preschool ; Children ; Fever ; Fever - etiology ; Hematologic and hematopoietic diseases ; Humans ; Hypotension ; Infections ; Major Articles ; Medical sciences ; Modeling ; Models, Statistical ; Neoplasms - complications ; Neutropenia ; Neutropenia - etiology ; Other diseases. Hematologic involvement in other diseases ; Predisposing factors ; Prospective Studies ; Reproducibility of Results ; Risk Factors</subject><ispartof>Clinical infectious diseases, 2002-09, Vol.35 (6), p.678-683</ispartof><rights>Copyright 2002 The Infectious Diseases Society of America</rights><rights>2002 by the Infectious Diseases Society of America 2002</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-192589c835cd1ab842da4237980fb5a407e9ed0c6d2f2d4ad725a4cd3e37b43c3</citedby><cites>FETCH-LOGICAL-c421t-192589c835cd1ab842da4237980fb5a407e9ed0c6d2f2d4ad725a4cd3e37b43c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/4462182$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/4462182$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13919476$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12203164$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Santolaya, M. E.</creatorcontrib><creatorcontrib>Alvarez, A. M.</creatorcontrib><creatorcontrib>Avilés, C. L.</creatorcontrib><creatorcontrib>Becker, A.</creatorcontrib><creatorcontrib>Cofré, J.</creatorcontrib><creatorcontrib>Enríquez, N.</creatorcontrib><creatorcontrib>O'Ryan, M.</creatorcontrib><creatorcontrib>Payá, E.</creatorcontrib><creatorcontrib>Salgado, C.</creatorcontrib><creatorcontrib>Silva, P.</creatorcontrib><creatorcontrib>Tordecilla, J.</creatorcontrib><creatorcontrib>Varas, M.</creatorcontrib><creatorcontrib>Villarroel, M.</creatorcontrib><creatorcontrib>Viviani, T.</creatorcontrib><creatorcontrib>Zubieta, M.</creatorcontrib><title>Prospective Evaluation of a Model of Prediction of Invasive Bacterial Infection Risk among Children with Cancer, Fever, and Neutropenia</title><title>Clinical infectious diseases</title><addtitle>Clinical Infectious Diseases</addtitle><addtitle>Clinical Infectious Diseases</addtitle><description>A risk prediction model for invasive bacterial infection (IBI) was prospectively evaluated among children presenting with cancer, fever, and neutropenia. The model incorporated assessment of 5 previously identified risk factors: serum level of C-reactive protein (CRP) ⩾90 mg/L, hypotension, identification of relapse of leukemia as the cancer type, platelet count of ⩽50,000 platelets/mm3, and recent receipt of chemotherapy [16]. Children were uniformly evaluated at enrollment and were classified as having high or low risk for IBI according to a model that considers the number and type of variables present. Of the 263 febrile episodes evaluated during a 17-month period, 140 (53%) were in IBI-positive children. The sensitivity, specificity, and positive and negative predictive values of the model were 92%, 76%, 82%, and 90%, respectively. Identification of these 5 risk factors during the first 24 h of hospitalization was helpful in discriminating between children with a high or low risk for IBI.</description><subject>Adolescent</subject><subject>Bacteremia</subject><subject>Bacterial infections</subject><subject>Bacterial Infections - epidemiology</subject><subject>Bacterial Infections - etiology</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child health services</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Fever</subject><subject>Fever - etiology</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Hypotension</subject><subject>Infections</subject><subject>Major Articles</subject><subject>Medical sciences</subject><subject>Modeling</subject><subject>Models, Statistical</subject><subject>Neoplasms - complications</subject><subject>Neutropenia</subject><subject>Neutropenia - etiology</subject><subject>Other diseases. Hematologic involvement in other diseases</subject><subject>Predisposing factors</subject><subject>Prospective Studies</subject><subject>Reproducibility of Results</subject><subject>Risk Factors</subject><issn>1058-4838</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0c1u1DAQB_AIgWgp8AQIhQOcCPg7zpGuWrZiC1UFEurFmrUn1G02XuxkgSfgtfEqS_eEOHk0_5_G0kxRPKXkDSVaveWCESXuFYdU8rpSsqH3c02kroTm-qB4lNINIZRqIh8WB5QxwqkSh8XvixjSGu3gN1iebKAbYfChL0NbQnkeHHbb8iKi8_ZvcNZvIG39MdgBo4cut1qc8kufbktYhf5bObv2nYvYlz_8cF3OoLcYX5enuNk-0LvyI45DDGvsPTwuHrTQJXyye4-KL6cnn2fzavHp_dns3aKygtGhog2TurGaS-soLLVgDgTjdaNJu5QgSI0NOmKVYy1zAlzNctc6jrxeCm75UfFqmruO4fuIaTArnyx2HfQYxmTqvBglJf8vpFopToTcQ5s3mSK2Zh39CuIvQ4nZ3sZMt8nw-W7iuFyh27PdMTJ4uQOQLHRtzBvzae94QxtRq-xeTC6M639_9mwyN2kI8U4JoRjVLMfVFPs04M-7GOKtUTWvpZl_vTIfjq8u53ohzDn_A3ETuJI</recordid><startdate>20020915</startdate><enddate>20020915</enddate><creator>Santolaya, M. E.</creator><creator>Alvarez, A. M.</creator><creator>Avilés, C. L.</creator><creator>Becker, A.</creator><creator>Cofré, J.</creator><creator>Enríquez, N.</creator><creator>O'Ryan, M.</creator><creator>Payá, E.</creator><creator>Salgado, C.</creator><creator>Silva, P.</creator><creator>Tordecilla, J.</creator><creator>Varas, M.</creator><creator>Villarroel, M.</creator><creator>Viviani, T.</creator><creator>Zubieta, M.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20020915</creationdate><title>Prospective Evaluation of a Model of Prediction of Invasive Bacterial Infection Risk among Children with Cancer, Fever, and Neutropenia</title><author>Santolaya, M. E. ; Alvarez, A. M. ; Avilés, C. L. ; Becker, A. ; Cofré, J. ; Enríquez, N. ; O'Ryan, M. ; Payá, E. ; Salgado, C. ; Silva, P. ; Tordecilla, J. ; Varas, M. ; Villarroel, M. ; Viviani, T. ; Zubieta, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-192589c835cd1ab842da4237980fb5a407e9ed0c6d2f2d4ad725a4cd3e37b43c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adolescent</topic><topic>Bacteremia</topic><topic>Bacterial infections</topic><topic>Bacterial Infections - epidemiology</topic><topic>Bacterial Infections - etiology</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child health services</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Fever</topic><topic>Fever - etiology</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Hypotension</topic><topic>Infections</topic><topic>Major Articles</topic><topic>Medical sciences</topic><topic>Modeling</topic><topic>Models, Statistical</topic><topic>Neoplasms - complications</topic><topic>Neutropenia</topic><topic>Neutropenia - etiology</topic><topic>Other diseases. 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L.</au><au>Becker, A.</au><au>Cofré, J.</au><au>Enríquez, N.</au><au>O'Ryan, M.</au><au>Payá, E.</au><au>Salgado, C.</au><au>Silva, P.</au><au>Tordecilla, J.</au><au>Varas, M.</au><au>Villarroel, M.</au><au>Viviani, T.</au><au>Zubieta, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prospective Evaluation of a Model of Prediction of Invasive Bacterial Infection Risk among Children with Cancer, Fever, and Neutropenia</atitle><jtitle>Clinical infectious diseases</jtitle><stitle>Clinical Infectious Diseases</stitle><addtitle>Clinical Infectious Diseases</addtitle><date>2002-09-15</date><risdate>2002</risdate><volume>35</volume><issue>6</issue><spage>678</spage><epage>683</epage><pages>678-683</pages><issn>1058-4838</issn><eissn>1537-6591</eissn><coden>CIDIEL</coden><abstract>A risk prediction model for invasive bacterial infection (IBI) was prospectively evaluated among children presenting with cancer, fever, and neutropenia. The model incorporated assessment of 5 previously identified risk factors: serum level of C-reactive protein (CRP) ⩾90 mg/L, hypotension, identification of relapse of leukemia as the cancer type, platelet count of ⩽50,000 platelets/mm3, and recent receipt of chemotherapy [16]. Children were uniformly evaluated at enrollment and were classified as having high or low risk for IBI according to a model that considers the number and type of variables present. Of the 263 febrile episodes evaluated during a 17-month period, 140 (53%) were in IBI-positive children. The sensitivity, specificity, and positive and negative predictive values of the model were 92%, 76%, 82%, and 90%, respectively. Identification of these 5 risk factors during the first 24 h of hospitalization was helpful in discriminating between children with a high or low risk for IBI.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>12203164</pmid><doi>10.1086/342064</doi><tpages>6</tpages></addata></record> |
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| subjects | Adolescent Bacteremia Bacterial infections Bacterial Infections - epidemiology Bacterial Infections - etiology Biological and medical sciences Child Child health services Child, Preschool Children Fever Fever - etiology Hematologic and hematopoietic diseases Humans Hypotension Infections Major Articles Medical sciences Modeling Models, Statistical Neoplasms - complications Neutropenia Neutropenia - etiology Other diseases. Hematologic involvement in other diseases Predisposing factors Prospective Studies Reproducibility of Results Risk Factors |
| title | Prospective Evaluation of a Model of Prediction of Invasive Bacterial Infection Risk among Children with Cancer, Fever, and Neutropenia |
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