Association of Cervical Ectopy with Heterosexual Transmission of Human Immunodeficiency Virus: Results of a Study of Couples in Nairobi, Kenya
To identify risk factors involved in heterosexual transmission of human immunodeficiency virus (HIV), a cross-sectional study of HIV-seropositive men and their spouses was conducted in Nairobi, Kenya. Of 70 spouses, 40 (57%) were seropositive and 30 (43%) were seronegative for HIV. In univariate ana...
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| Veröffentlicht in: | The Journal of infectious diseases 1991-09, Vol.164 (3), p.588-591 |
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| creator | Moss, Gregory B. Clemetson, David D'Costa, Lourdes Plummer, Francis A. Ndinya-Achola, J. O. Reilly, Marie Holmes, King K. Piot, Peter Maitha, Gregory M. Hillier, Sharon L. Kiviat, Nancy C. Cameron, C. William Wamola, I. A. Kreiss, Joan K. |
| description | To identify risk factors involved in heterosexual transmission of human immunodeficiency virus (HIV), a cross-sectional study of HIV-seropositive men and their spouses was conducted in Nairobi, Kenya. Of 70 spouses, 40 (57%) were seropositive and 30 (43%) were seronegative for HIV. In univariate analysis, the presence of cervical ectopy (odds ratio, 4.7; P = .006) was the only statistically significant variable associated with HIV infection in women. After controlling for possible confounding variables using multivariate logistic regression analysis, the presence of cervical ectopy (odds ratio, 5.0; P = .007) remained the only independent predictor of HIV seropositivity. These findings suggest that cervical ectopy may be a newly identified risk factor for heterosexual transmission of HIV. |
| doi_str_mv | 10.1093/infdis/164.3.588 |
| format | Article |
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O. ; Reilly, Marie ; Holmes, King K. ; Piot, Peter ; Maitha, Gregory M. ; Hillier, Sharon L. ; Kiviat, Nancy C. ; Cameron, C. William ; Wamola, I. A. ; Kreiss, Joan K.</creator><creatorcontrib>Moss, Gregory B. ; Clemetson, David ; D'Costa, Lourdes ; Plummer, Francis A. ; Ndinya-Achola, J. O. ; Reilly, Marie ; Holmes, King K. ; Piot, Peter ; Maitha, Gregory M. ; Hillier, Sharon L. ; Kiviat, Nancy C. ; Cameron, C. William ; Wamola, I. A. ; Kreiss, Joan K.</creatorcontrib><description>To identify risk factors involved in heterosexual transmission of human immunodeficiency virus (HIV), a cross-sectional study of HIV-seropositive men and their spouses was conducted in Nairobi, Kenya. Of 70 spouses, 40 (57%) were seropositive and 30 (43%) were seronegative for HIV. In univariate analysis, the presence of cervical ectopy (odds ratio, 4.7; P = .006) was the only statistically significant variable associated with HIV infection in women. After controlling for possible confounding variables using multivariate logistic regression analysis, the presence of cervical ectopy (odds ratio, 5.0; P = .007) remained the only independent predictor of HIV seropositivity. These findings suggest that cervical ectopy may be a newly identified risk factor for heterosexual transmission of HIV.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/164.3.588</identifier><identifier>PMID: 1869844</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Adult ; Age distribution ; AIDS ; AIDS/HIV ; Biological and medical sciences ; Cervix uteri ; Concise Communications ; Female ; Genitalia ; Heterosexual transmission ; HIV ; HIV infections ; HIV Seropositivity - complications ; HIV Seropositivity - epidemiology ; HIV Seropositivity - transmission ; Humans ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunopathology ; Infections ; Kenya - epidemiology ; Male ; Medical sciences ; Oral contraceptives ; Predisposing factors ; Regression Analysis ; Risk Factors ; Sexual Behavior ; Sexual Partners ; Tropical medicine ; Uterine Cervical Diseases - complications</subject><ispartof>The Journal of infectious diseases, 1991-09, Vol.164 (3), p.588-591</ispartof><rights>Copyright 1991 The University of Chicago</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c383t-a4a53d0af04ef30c1cdbe70aea53c40fb1a4757acf3cb0e826db8cd978ae716f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30111709$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30111709$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5403028$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1869844$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moss, Gregory B.</creatorcontrib><creatorcontrib>Clemetson, David</creatorcontrib><creatorcontrib>D'Costa, Lourdes</creatorcontrib><creatorcontrib>Plummer, Francis A.</creatorcontrib><creatorcontrib>Ndinya-Achola, J. O.</creatorcontrib><creatorcontrib>Reilly, Marie</creatorcontrib><creatorcontrib>Holmes, King K.</creatorcontrib><creatorcontrib>Piot, Peter</creatorcontrib><creatorcontrib>Maitha, Gregory M.</creatorcontrib><creatorcontrib>Hillier, Sharon L.</creatorcontrib><creatorcontrib>Kiviat, Nancy C.</creatorcontrib><creatorcontrib>Cameron, C. William</creatorcontrib><creatorcontrib>Wamola, I. A.</creatorcontrib><creatorcontrib>Kreiss, Joan K.</creatorcontrib><title>Association of Cervical Ectopy with Heterosexual Transmission of Human Immunodeficiency Virus: Results of a Study of Couples in Nairobi, Kenya</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>To identify risk factors involved in heterosexual transmission of human immunodeficiency virus (HIV), a cross-sectional study of HIV-seropositive men and their spouses was conducted in Nairobi, Kenya. Of 70 spouses, 40 (57%) were seropositive and 30 (43%) were seronegative for HIV. In univariate analysis, the presence of cervical ectopy (odds ratio, 4.7; P = .006) was the only statistically significant variable associated with HIV infection in women. After controlling for possible confounding variables using multivariate logistic regression analysis, the presence of cervical ectopy (odds ratio, 5.0; P = .007) remained the only independent predictor of HIV seropositivity. These findings suggest that cervical ectopy may be a newly identified risk factor for heterosexual transmission of HIV.</description><subject>Adult</subject><subject>Age distribution</subject><subject>AIDS</subject><subject>AIDS/HIV</subject><subject>Biological and medical sciences</subject><subject>Cervix uteri</subject><subject>Concise Communications</subject><subject>Female</subject><subject>Genitalia</subject><subject>Heterosexual transmission</subject><subject>HIV</subject><subject>HIV infections</subject><subject>HIV Seropositivity - complications</subject><subject>HIV Seropositivity - epidemiology</subject><subject>HIV Seropositivity - transmission</subject><subject>Humans</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunopathology</subject><subject>Infections</subject><subject>Kenya - epidemiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Oral contraceptives</subject><subject>Predisposing factors</subject><subject>Regression Analysis</subject><subject>Risk Factors</subject><subject>Sexual Behavior</subject><subject>Sexual Partners</subject><subject>Tropical medicine</subject><subject>Uterine Cervical Diseases - complications</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkc1u1DAUhS0EKsPAng2SF4gVmdpxEnvYVUNhqo6KRAtC3ViOcy1cknjwDzQvwTPjkqGwsuTv3HPtcxB6TsmKkjU7tqPpbDimTbViq1qIB2hBa8aLpqHsIVoQUpYFFev1Y_QkhBtCSMUafoSOqGjWoqoW6NdJCE5bFa0bsTN4A_6H1arHpzq6_YR_2vgVbyGCdwFuUwZXXo1hsCEcJrZpUCM-G4Y0ug6M1RZGPeHP1qfwBn-EkPoY7oQKX8bUTX-2uLTvIWA74gtlvWvta3wO46SeokdG9QGeHc4l-vTu9GqzLXYf3p9tTnaFZoLFQlWqZh1RhlRgGNFUdy1woiBf64qYlqqK11xpw3RLQJRN1wrdrblQwGlj2BK9mn333n1PEKLMP9LQ92oEl4LkJWENpTQLySzUOYDgwci9t4Pyk6RE3lUg5wpkrkAymSvIIy8O3qkdoPs3MGee-csDVyEnbXKeOhv8ldUVYaT8z-YmROfvMSP5WTwvXqJi5jZEuL3nyn-TDWe8ltsv17I5F9e7y7e1vGC_ATGBrGY</recordid><startdate>19910901</startdate><enddate>19910901</enddate><creator>Moss, Gregory B.</creator><creator>Clemetson, David</creator><creator>D'Costa, Lourdes</creator><creator>Plummer, Francis A.</creator><creator>Ndinya-Achola, J. O.</creator><creator>Reilly, Marie</creator><creator>Holmes, King K.</creator><creator>Piot, Peter</creator><creator>Maitha, Gregory M.</creator><creator>Hillier, Sharon L.</creator><creator>Kiviat, Nancy C.</creator><creator>Cameron, C. William</creator><creator>Wamola, I. A.</creator><creator>Kreiss, Joan K.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19910901</creationdate><title>Association of Cervical Ectopy with Heterosexual Transmission of Human Immunodeficiency Virus: Results of a Study of Couples in Nairobi, Kenya</title><author>Moss, Gregory B. ; Clemetson, David ; D'Costa, Lourdes ; Plummer, Francis A. ; Ndinya-Achola, J. O. ; Reilly, Marie ; Holmes, King K. ; Piot, Peter ; Maitha, Gregory M. ; Hillier, Sharon L. ; Kiviat, Nancy C. ; Cameron, C. William ; Wamola, I. 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Immunoglobulinopathies</topic><topic>Immunopathology</topic><topic>Infections</topic><topic>Kenya - epidemiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Oral contraceptives</topic><topic>Predisposing factors</topic><topic>Regression Analysis</topic><topic>Risk Factors</topic><topic>Sexual Behavior</topic><topic>Sexual Partners</topic><topic>Tropical medicine</topic><topic>Uterine Cervical Diseases - complications</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moss, Gregory B.</creatorcontrib><creatorcontrib>Clemetson, David</creatorcontrib><creatorcontrib>D'Costa, Lourdes</creatorcontrib><creatorcontrib>Plummer, Francis A.</creatorcontrib><creatorcontrib>Ndinya-Achola, J. 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A.</au><au>Kreiss, Joan K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of Cervical Ectopy with Heterosexual Transmission of Human Immunodeficiency Virus: Results of a Study of Couples in Nairobi, Kenya</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1991-09-01</date><risdate>1991</risdate><volume>164</volume><issue>3</issue><spage>588</spage><epage>591</epage><pages>588-591</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>To identify risk factors involved in heterosexual transmission of human immunodeficiency virus (HIV), a cross-sectional study of HIV-seropositive men and their spouses was conducted in Nairobi, Kenya. Of 70 spouses, 40 (57%) were seropositive and 30 (43%) were seronegative for HIV. In univariate analysis, the presence of cervical ectopy (odds ratio, 4.7; P = .006) was the only statistically significant variable associated with HIV infection in women. After controlling for possible confounding variables using multivariate logistic regression analysis, the presence of cervical ectopy (odds ratio, 5.0; P = .007) remained the only independent predictor of HIV seropositivity. These findings suggest that cervical ectopy may be a newly identified risk factor for heterosexual transmission of HIV.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>1869844</pmid><doi>10.1093/infdis/164.3.588</doi><tpages>4</tpages></addata></record> |
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| ispartof | The Journal of infectious diseases, 1991-09, Vol.164 (3), p.588-591 |
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| subjects | Adult Age distribution AIDS AIDS/HIV Biological and medical sciences Cervix uteri Concise Communications Female Genitalia Heterosexual transmission HIV HIV infections HIV Seropositivity - complications HIV Seropositivity - epidemiology HIV Seropositivity - transmission Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infections Kenya - epidemiology Male Medical sciences Oral contraceptives Predisposing factors Regression Analysis Risk Factors Sexual Behavior Sexual Partners Tropical medicine Uterine Cervical Diseases - complications |
| title | Association of Cervical Ectopy with Heterosexual Transmission of Human Immunodeficiency Virus: Results of a Study of Couples in Nairobi, Kenya |
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