Maintenance of osteoblastic and adipocytic differentiation potential with age and osteoporosis in human marrow stromal cell cultures

Osteoblasts and adipocytes share a common precursor cell in the bone marrow stroma, termed marrow stromal cell (MSC). As the volume of bone adipose tissue increases in vivo with age, we hypothesized that decreased bone formation observed during aging and in patients with osteoporosis (OP) is the res...

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Veröffentlicht in:	Calcified tissue international 2002-07, Vol.71 (1), p.36-44
Hauptverfasser:	Justesen, J, Stenderup, K, Eriksen, E F, Kassem, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes - cytology Adipocytes - pathology Adult Age Factors Aging - physiology Alkaline Phosphatase - analysis Biomarkers - analysis Bone Density - physiology Bone Marrow Cells - cytology Cell Differentiation - physiology Cell Separation - methods Cells, Cultured Colony-Forming Units Assay DNA Primers Female Femur - physiology Humans Lumbar Vertebrae - physiology Male Middle Aged Osteoblasts - cytology Osteoblasts - pathology Osteoporosis - pathology Reference Values Reverse Transcriptase Polymerase Chain Reaction Stromal Cells - cytology
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