Cloning, sequencing, and expression of two murine 2'-5'-oligoadenylate synthetases. Structure-function relationships

2'-5'-oligoadenylate synthetases constitute a multimember family of interferon-inducible enzymes which need double-stranded RNA as an obligatory cofactor. We have isolated cDNA clones for two new murine synthetases. These two clones, 9-2 and 3-9, encoded proteins of 414 and 363 amino acid...

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Veröffentlicht in:	The Journal of biological chemistry 1991-08, Vol.266 (23), p.15293-15299
Hauptverfasser:	GHOSH, S. K, KUSARI, J, BANDYOPADHYAY, S. K, SAMANTA, H, KUMAR, R, SEN, G. C
Format:	Artikel
Sprache:	eng
Schlagworte:	2',5'-Oligoadenylate Synthetase - biosynthesis 2',5'-Oligoadenylate Synthetase - genetics Amino Acid Sequence Analytical, structural and metabolic biochemistry Animals Base Sequence Biological and medical sciences Chromatography, Thin Layer Cloning, Molecular DNA - genetics Electrophoresis, Agar Gel Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology Genes, Viral Mice Molecular Sequence Data Polymerase Chain Reaction Protein Biosynthesis RNA, Double-Stranded - genetics Sequence Homology, Nucleic Acid Structure-Activity Relationship Transcription, Genetic Transferases Vesicular stomatitis Indiana virus - genetics
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