Differential metabolism of alprazolam by liver and brain cytochrome (P4503A) to pharmacologically active metabolite

Cytochrome P450 (P450) is a superfamily of enzymes which mediates metabolism of xenobiotics including drugs. Alprazolam, an anti-anxiety agent, is metabolized in rat and human liver by P4503A1 and P4503A4 respectively, to 4-hydroxy alprazolam (4-OHALP, pharmacologically less active) and α-hydroxy al...

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Veröffentlicht in:	The pharmacogenomics journal 2002, Vol.2 (4), p.243-258
Hauptverfasser:	Pai, H V, Upadhya, S C, Chinta, S J, Hegde, S N, Ravindranath, V
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Alprazolam Alprazolam - metabolism Alprazolam - pharmacokinetics Animals Anti-Anxiety Agents - metabolism Anti-Anxiety Agents - pharmacokinetics Anxiety Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors Aryl Hydrocarbon Hydroxylases - metabolism Biological and medical sciences Biomedical and Life Sciences Biomedicine Biotransformation Blotting, Northern Brain Brain - enzymology Cerebrospinal fluid Child Cytochrome Cytochrome P-450 Cytochrome P-450 CYP3A Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Enzyme System - metabolism Cytochrome P450 Drug metabolism Enzyme Inhibitors - pharmacology Female Fluorescent Antibody Technique Gene Expression Genetic aspects Human Genetics Humans Immunohistochemistry In Situ Hybridization, Fluorescence In Vitro Techniques Liver Liver - enzymology Male Medical sciences Metabolism Metabolites Microsomes Microsomes, Liver - drug effects Microsomes, Liver - metabolism Middle Aged Neuropharmacology Oncology Organ Specificity original-article Pharmacology. Drug treatments Pharmacotherapy Physiological aspects Properties Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Rats, Wistar Species Specificity Xenobiotics
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