Sheng-Mai-San is Protective Against Post-Ischemic Myocardial Dysfunction in Rats Through Its Opening of the Mitochondrial KATP Channels

The present study used isolated rat hearts to investigate whether (1) Sheng-Mei-San (SMS), a traditional Chinese formulation comprising Radix Ginseng, Radix Ophiopogonis and Fructus Schisandrae, is protective against post-ischemic myocardial dysfunction, and (2) whether the cardioprotective effect o...

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Veröffentlicht in:	Circulation Journal 2002, Vol.66(8), pp.763-768
Hauptverfasser:	Wang, Ningyuan, Minatoguchi, Shinya, Arai, Masazumi, Uno, Yoshihiro, Nishida, Yoshio, Hashimoto, Kazuaki, Xue-Hai, Chen, Fukuda, Kazunori, Akao, Seigo, Takemura, Genzou, Fujiwara, Hisayoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Animals Antianginal agents. Coronary vasodilator agents Biological and medical sciences Cardiomyopathies - prevention & control Cardiotonic Agents - therapeutic use Cardiovascular system Drug Combinations Drugs, Chinese Herbal - therapeutic use Free radicals Gentisates Hydroxybenzoates - metabolism In Vitro Techniques Ischemia-reperfusion Isolated rat heart L-Lactate Dehydrogenase - metabolism Lactic Acid - metabolism Male Medical sciences Mitochondria, Heart - metabolism Mitochondrial KATP channel Myocardial Ischemia - drug therapy Myocardial Ischemia - physiopathology Myocardium - metabolism Pharmacology. Drug treatments Potassium Channels - drug effects Potassium Channels - metabolism Rats Rats, Sprague-Dawley Recovery of Function Sheng-Mai-San Ventricular Function, Left
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