Atypical epithelial proliferations in acquired renal cystic disease harbor cytogenetic aberrations
Acquired renal cystic disease (ARCD) complicating end-stage renal failure confers an increased risk for renal cell carcinoma, and atypical epithelial proliferation in the cysts may represent the precursor lesion. In this report we used an interphase cytogenetic technique to analyze the karyotypic fe...
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| Veröffentlicht in: | Human pathology 2002-07, Vol.33 (7), p.761-765 |
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| creator | Cheuk, Wah Lo, Elena S.F. Chan, Amanda K.C. Chan, John K.C. |
| description | Acquired renal cystic disease (ARCD) complicating end-stage renal failure confers an increased risk for renal cell carcinoma, and atypical epithelial proliferation in the cysts may represent the precursor lesion. In this report we used an interphase cytogenetic technique to analyze the karyotypic features of various forms of atypical epithelial proliferations in a patient with ARCD. Both kidneys harbored numerous simple and atypical cysts. In addition, papillary tufts and a hitherto undescribed cribriform epithelial proliferation were found in the right kidney. The left kidney contained a 10-mm renal cell carcinoma with features indeterminate between clear cell and papillary types. There was gain of chromosome 7 in the papillary tufts; gain of chromosomes 7 and 17 in the cribriform lesion; gain of chromosomes 7, 12, 17, 20, and Y in the atypical cysts; and gain of chromosomes 7, 12, 17, and 20 in the renal cell carcinoma. These chromosomal aberrations suggest that atypical epithelial proliferations in ARCD represent early neoplastic lesions. HUM PATHOL 33:761-765. Copyright 2002, Elsevier Science (USA). All rights reserved. |
| doi_str_mv | 10.1053/hupa.2002.125370 |
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In this report we used an interphase cytogenetic technique to analyze the karyotypic features of various forms of atypical epithelial proliferations in a patient with ARCD. Both kidneys harbored numerous simple and atypical cysts. In addition, papillary tufts and a hitherto undescribed cribriform epithelial proliferation were found in the right kidney. The left kidney contained a 10-mm renal cell carcinoma with features indeterminate between clear cell and papillary types. There was gain of chromosome 7 in the papillary tufts; gain of chromosomes 7 and 17 in the cribriform lesion; gain of chromosomes 7, 12, 17, 20, and Y in the atypical cysts; and gain of chromosomes 7, 12, 17, and 20 in the renal cell carcinoma. These chromosomal aberrations suggest that atypical epithelial proliferations in ARCD represent early neoplastic lesions. HUM PATHOL 33:761-765. Copyright 2002, Elsevier Science (USA). All rights reserved.</description><identifier>ISSN: 0046-8177</identifier><identifier>EISSN: 1532-8392</identifier><identifier>DOI: 10.1053/hupa.2002.125370</identifier><identifier>PMID: 12196929</identifier><identifier>CODEN: HPCQA4</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>acquired renal cystic disease ; Adult ; atypical epithelial proliferation ; Biological and medical sciences ; Carcinoma, Renal Cell - etiology ; Carcinoma, Renal Cell - genetics ; Carcinoma, Renal Cell - pathology ; Cell Division ; chromogenic in-situ hybridization ; Chromosome Aberrations ; cribriform epithelial proliferation ; Cytogenetic Analysis ; cytogenetics ; DNA, Neoplasm - analysis ; Epithelial Cells - pathology ; Humans ; In Situ Hybridization ; Kidney Diseases, Cystic - complications ; Kidney Diseases, Cystic - genetics ; Kidney Diseases, Cystic - pathology ; Kidney Neoplasms - etiology ; Kidney Neoplasms - genetics ; Kidney Neoplasms - pathology ; Kidneys ; Male ; Medical sciences ; Nephrology. Urinary tract diseases ; Precancerous Conditions - genetics ; Precancerous Conditions - pathology ; renal cell carcinoma ; Renal Dialysis ; Signal Processing, Computer-Assisted ; Tumors of the urinary system</subject><ispartof>Human pathology, 2002-07, Vol.33 (7), p.761-765</ispartof><rights>2002 Elsevier Science (USA)</rights><rights>2002 INIST-CNRS</rights><rights>Copyright 2002, Elsevier Science (USA). All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-d1e15bc4de66342a9c4b3ee1a69933a7b06948e5acea8ae9542883a2863edf43</citedby><cites>FETCH-LOGICAL-c442t-d1e15bc4de66342a9c4b3ee1a69933a7b06948e5acea8ae9542883a2863edf43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1053/hupa.2002.125370$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13884156$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12196929$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cheuk, Wah</creatorcontrib><creatorcontrib>Lo, Elena S.F.</creatorcontrib><creatorcontrib>Chan, Amanda K.C.</creatorcontrib><creatorcontrib>Chan, John K.C.</creatorcontrib><title>Atypical epithelial proliferations in acquired renal cystic disease harbor cytogenetic aberrations</title><title>Human pathology</title><addtitle>Hum Pathol</addtitle><description>Acquired renal cystic disease (ARCD) complicating end-stage renal failure confers an increased risk for renal cell carcinoma, and atypical epithelial proliferation in the cysts may represent the precursor lesion. In this report we used an interphase cytogenetic technique to analyze the karyotypic features of various forms of atypical epithelial proliferations in a patient with ARCD. Both kidneys harbored numerous simple and atypical cysts. In addition, papillary tufts and a hitherto undescribed cribriform epithelial proliferation were found in the right kidney. The left kidney contained a 10-mm renal cell carcinoma with features indeterminate between clear cell and papillary types. There was gain of chromosome 7 in the papillary tufts; gain of chromosomes 7 and 17 in the cribriform lesion; gain of chromosomes 7, 12, 17, 20, and Y in the atypical cysts; and gain of chromosomes 7, 12, 17, and 20 in the renal cell carcinoma. These chromosomal aberrations suggest that atypical epithelial proliferations in ARCD represent early neoplastic lesions. HUM PATHOL 33:761-765. Copyright 2002, Elsevier Science (USA). All rights reserved.</description><subject>acquired renal cystic disease</subject><subject>Adult</subject><subject>atypical epithelial proliferation</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Renal Cell - etiology</subject><subject>Carcinoma, Renal Cell - genetics</subject><subject>Carcinoma, Renal Cell - pathology</subject><subject>Cell Division</subject><subject>chromogenic in-situ hybridization</subject><subject>Chromosome Aberrations</subject><subject>cribriform epithelial proliferation</subject><subject>Cytogenetic Analysis</subject><subject>cytogenetics</subject><subject>DNA, Neoplasm - analysis</subject><subject>Epithelial Cells - pathology</subject><subject>Humans</subject><subject>In Situ Hybridization</subject><subject>Kidney Diseases, Cystic - complications</subject><subject>Kidney Diseases, Cystic - genetics</subject><subject>Kidney Diseases, Cystic - pathology</subject><subject>Kidney Neoplasms - etiology</subject><subject>Kidney Neoplasms - genetics</subject><subject>Kidney Neoplasms - pathology</subject><subject>Kidneys</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Precancerous Conditions - genetics</subject><subject>Precancerous Conditions - pathology</subject><subject>renal cell carcinoma</subject><subject>Renal Dialysis</subject><subject>Signal Processing, Computer-Assisted</subject><subject>Tumors of the urinary system</subject><issn>0046-8177</issn><issn>1532-8392</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMtLxDAQh4Mouj7unqQXvXXNs028ifgCwYv3ME2nbqTb1qQV9r83ZQuePM0w8_2G4SPkktE1o0rcbqYB1pxSvmZciZIekBVTgudaGH5IVpTKItesLE_IaYxflDKmpDomJ4wzUxhuVqS6H3eDd9BmOPhxg61P7RD61jcYYPR9FzPfZeC-Jx-wzgJ2CXC7OHqX1T4iRMw2EKo-pOnYf2KH8woqDEv-nBw10Ea8WOoZ-Xh6_Hh4yd_en18f7t9yJyUf85ohU5WTNRaFkByMk5VAZFAYIwSUFS2M1KjAIWhAoyTXWgDXhcC6keKM3OzPpu-_J4yj3frosG2hw36KtuRUCKpnkO5BF_oYAzZ2CH4LYWcZtbNWO2u1s1a715oiV8vtqdpi_RdYPCbgegEgJplNgM75-McJrSVTReLu9hwmET8eg43OY-ewTnbdaOve___FL1xVloo</recordid><startdate>20020701</startdate><enddate>20020701</enddate><creator>Cheuk, Wah</creator><creator>Lo, Elena S.F.</creator><creator>Chan, Amanda K.C.</creator><creator>Chan, John K.C.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020701</creationdate><title>Atypical epithelial proliferations in acquired renal cystic disease harbor cytogenetic aberrations</title><author>Cheuk, Wah ; Lo, Elena S.F. ; Chan, Amanda K.C. ; Chan, John K.C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-d1e15bc4de66342a9c4b3ee1a69933a7b06948e5acea8ae9542883a2863edf43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>acquired renal cystic disease</topic><topic>Adult</topic><topic>atypical epithelial proliferation</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Renal Cell - etiology</topic><topic>Carcinoma, Renal Cell - genetics</topic><topic>Carcinoma, Renal Cell - pathology</topic><topic>Cell Division</topic><topic>chromogenic in-situ hybridization</topic><topic>Chromosome Aberrations</topic><topic>cribriform epithelial proliferation</topic><topic>Cytogenetic Analysis</topic><topic>cytogenetics</topic><topic>DNA, Neoplasm - analysis</topic><topic>Epithelial Cells - pathology</topic><topic>Humans</topic><topic>In Situ Hybridization</topic><topic>Kidney Diseases, Cystic - complications</topic><topic>Kidney Diseases, Cystic - genetics</topic><topic>Kidney Diseases, Cystic - pathology</topic><topic>Kidney Neoplasms - etiology</topic><topic>Kidney Neoplasms - genetics</topic><topic>Kidney Neoplasms - pathology</topic><topic>Kidneys</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Precancerous Conditions - genetics</topic><topic>Precancerous Conditions - pathology</topic><topic>renal cell carcinoma</topic><topic>Renal Dialysis</topic><topic>Signal Processing, Computer-Assisted</topic><topic>Tumors of the urinary system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cheuk, Wah</creatorcontrib><creatorcontrib>Lo, Elena S.F.</creatorcontrib><creatorcontrib>Chan, Amanda K.C.</creatorcontrib><creatorcontrib>Chan, John K.C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Human pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheuk, Wah</au><au>Lo, Elena S.F.</au><au>Chan, Amanda K.C.</au><au>Chan, John K.C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Atypical epithelial proliferations in acquired renal cystic disease harbor cytogenetic aberrations</atitle><jtitle>Human pathology</jtitle><addtitle>Hum Pathol</addtitle><date>2002-07-01</date><risdate>2002</risdate><volume>33</volume><issue>7</issue><spage>761</spage><epage>765</epage><pages>761-765</pages><issn>0046-8177</issn><eissn>1532-8392</eissn><coden>HPCQA4</coden><abstract>Acquired renal cystic disease (ARCD) complicating end-stage renal failure confers an increased risk for renal cell carcinoma, and atypical epithelial proliferation in the cysts may represent the precursor lesion. In this report we used an interphase cytogenetic technique to analyze the karyotypic features of various forms of atypical epithelial proliferations in a patient with ARCD. Both kidneys harbored numerous simple and atypical cysts. In addition, papillary tufts and a hitherto undescribed cribriform epithelial proliferation were found in the right kidney. The left kidney contained a 10-mm renal cell carcinoma with features indeterminate between clear cell and papillary types. There was gain of chromosome 7 in the papillary tufts; gain of chromosomes 7 and 17 in the cribriform lesion; gain of chromosomes 7, 12, 17, 20, and Y in the atypical cysts; and gain of chromosomes 7, 12, 17, and 20 in the renal cell carcinoma. These chromosomal aberrations suggest that atypical epithelial proliferations in ARCD represent early neoplastic lesions. HUM PATHOL 33:761-765. Copyright 2002, Elsevier Science (USA). All rights reserved.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>12196929</pmid><doi>10.1053/hupa.2002.125370</doi><tpages>5</tpages></addata></record> |
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| subjects | acquired renal cystic disease Adult atypical epithelial proliferation Biological and medical sciences Carcinoma, Renal Cell - etiology Carcinoma, Renal Cell - genetics Carcinoma, Renal Cell - pathology Cell Division chromogenic in-situ hybridization Chromosome Aberrations cribriform epithelial proliferation Cytogenetic Analysis cytogenetics DNA, Neoplasm - analysis Epithelial Cells - pathology Humans In Situ Hybridization Kidney Diseases, Cystic - complications Kidney Diseases, Cystic - genetics Kidney Diseases, Cystic - pathology Kidney Neoplasms - etiology Kidney Neoplasms - genetics Kidney Neoplasms - pathology Kidneys Male Medical sciences Nephrology. Urinary tract diseases Precancerous Conditions - genetics Precancerous Conditions - pathology renal cell carcinoma Renal Dialysis Signal Processing, Computer-Assisted Tumors of the urinary system |
| title | Atypical epithelial proliferations in acquired renal cystic disease harbor cytogenetic aberrations |
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