Suppressive effect of the Gly389 allele of the beta1-adrenergic receptor gene on the occurrence of ventricular tachycardia in dilated cardiomyopathy

Beta-1-adrenergic receptor (beta1-AR) blockers reduce both the incidence of sudden death and the ventricular volume in heart failure. In vitro, the Gly389 variant of beta1-AR mediates less adenylyl cyclase activities than the Arg389 variant, so Arg389Gly polymorphism was investigated with regard to...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Circulation journal : official journal of the Japanese Circulation Society 2002, Vol.66 (8), p.723-728
Hauptverfasser:	Iwai, Chikao, Akita, Hozuka, Shiga, Nobuyuki, Takai, Eiji, Miyamoto, Yoshitomo, Shimizu, Masakatsu, Kawai, Hiroya, Takarada, Akira, Kajiya, Teishi, Yokoyama, Mitsuhiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Cardiomyopathy, Dilated - complications Female Gene Dosage Gene Frequency Genotype Glycine Humans Male Middle Aged Polymorphism, Genetic Receptors, Adrenergic, beta-1 - genetics Tachycardia, Ventricular - etiology Tachycardia, Ventricular - prevention & control
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!