Pseudophosphorylated prolactin (S179D PRL) inhibits growth and promotes beta-casein gene expression in the rat mammary gland

We have investigated the individual roles of unmodified prolactin (U-PRL) and a mimic of phosphorylated PRL (S179D PRL) in mammary development. Recombinant versions of the PRLs were delivered to rats throughout pregnancy at a rate of 6 microg/24 h per rat and to non-pregnant females at a rate of 24...

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Veröffentlicht in:	Cell and tissue research 2002-09, Vol.309 (3), p.429-437
Hauptverfasser:	Kuo, C Benson, Wu, Wei, Xu, Xiaolei, Yang, Lili, Chen, Cyndi, Coss, Djurdjica, Birdsall, Ben, Nasseri, Dorsa, Walker, Ameae M
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Animals Caseins - genetics Cell Division - drug effects Corticosterone - blood Estradiol - blood Female Gene Expression Regulation - drug effects Humans Mammary Glands, Animal - cytology Mammary Glands, Animal - drug effects Mammary Glands, Animal - physiology Phosphorylation Pregnancy Progesterone - blood Prolactin - analogs & derivatives Prolactin - pharmacology Rats Rats, Sprague-Dawley Recombinant Proteins - pharmacology
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