Significant Association of Longer Forms of CCTTT Microsatellite Repeat in the Inducible Nitric Oxide Synthase Promoter with Severe Malaria in Thailand
A CCTTT microsatellite repeat in the inducible nitric oxide synthase (iNOS) promoter was analyzed among 256 adult patients with severe Plasmodium falciparum malaria and 179 adult patients with mild malaria living in northwestern Thailand. Genotypes with longer forms of the CCTTT repeat (alleles of ⩾...
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| Veröffentlicht in: | The Journal of infectious diseases 2002-08, Vol.186 (4), p.578-581 |
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| creator | Ohashi, Jun Naka, Izumi Patarapotikul, Jintana Hananantachai, Hathairad Looareesuwan, Sornchai Tokunaga, Katsushi |
| description | A CCTTT microsatellite repeat in the inducible nitric oxide synthase (iNOS) promoter was analyzed among 256 adult patients with severe Plasmodium falciparum malaria and 179 adult patients with mild malaria living in northwestern Thailand. Genotypes with longer forms of the CCTTT repeat (alleles of ⩾15 repeats) were significantly associated with severe malaria (odds ratio [OR], 2.14; P=.0029, χ2 test). More interestingly, the summed repeat number of both microsatellite alleles in an individual was found to be a significant risk factor for severe malaria (OR, 1.11; logistic regression analysis, P=.0041). The single nucleotide substitution, −954G→C, in the iNOS promoter was rare in Thai patients with malaria. No variations were detected in the iNOS promoter region containing functional NF-κB elements at −5.2, −5.5, −5.8, and −6.1 kb upstream of the iNOS transcriptional start site. Thus, a CCTTT repeat in the iNOS promoter may play a key role in the pathogenesis of severe malaria |
| doi_str_mv | 10.1086/341779 |
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Genotypes with longer forms of the CCTTT repeat (alleles of ⩾15 repeats) were significantly associated with severe malaria (odds ratio [OR], 2.14; P=.0029, χ2 test). More interestingly, the summed repeat number of both microsatellite alleles in an individual was found to be a significant risk factor for severe malaria (OR, 1.11; logistic regression analysis, P=.0041). The single nucleotide substitution, −954G→C, in the iNOS promoter was rare in Thai patients with malaria. No variations were detected in the iNOS promoter region containing functional NF-κB elements at −5.2, −5.5, −5.8, and −6.1 kb upstream of the iNOS transcriptional start site. Thus, a CCTTT repeat in the iNOS promoter may play a key role in the pathogenesis of severe malaria</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/341779</identifier><identifier>PMID: 12195390</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Adult ; Alleles ; Animals ; Biological and medical sciences ; Blood ; Cerebral malaria ; Concise Communication ; Gene Frequency ; Genetic Variation ; Human protozoal diseases ; Humans ; Infectious diseases ; Logistic regression ; Malaria ; Malaria, Cerebral - genetics ; Malaria, Cerebral - parasitology ; Malaria, Cerebral - physiopathology ; Malaria, Falciparum - genetics ; Malaria, Falciparum - parasitology ; Malaria, Falciparum - physiopathology ; Medical sciences ; Microsatellite repeats ; Microsatellite Repeats - genetics ; Microsatellites ; NF-kappa B - genetics ; Nitric Oxide Synthase - chemistry ; Nitric Oxide Synthase - genetics ; Nitric Oxide Synthase - metabolism ; Nitric Oxide Synthase Type II ; Oxides ; Parasitic diseases ; Plasmodium falciparum - pathogenicity ; Polymerase chain reaction ; Polymorphism, Genetic ; Promoter regions ; Promoter Regions, Genetic - genetics ; Protozoal diseases ; Risk Factors ; Severity of Illness Index ; Thailand ; Tropical medicine</subject><ispartof>The Journal of infectious diseases, 2002-08, Vol.186 (4), p.578-581</ispartof><rights>Copyright 2002 Infectious Diseases Society of America</rights><rights>2002 by the Infectious Diseases Society of America 2002</rights><rights>2003 INIST-CNRS</rights><rights>Copyright University of Chicago, acting through its Press Aug 15, 2002</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-d65b31b8a89d651e6de66801730676e10feaa4fb8f8e9e8af451e515028a48b73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30084491$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30084491$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13843719$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12195390$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ohashi, Jun</creatorcontrib><creatorcontrib>Naka, Izumi</creatorcontrib><creatorcontrib>Patarapotikul, Jintana</creatorcontrib><creatorcontrib>Hananantachai, Hathairad</creatorcontrib><creatorcontrib>Looareesuwan, Sornchai</creatorcontrib><creatorcontrib>Tokunaga, Katsushi</creatorcontrib><title>Significant Association of Longer Forms of CCTTT Microsatellite Repeat in the Inducible Nitric Oxide Synthase Promoter with Severe Malaria in Thailand</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><addtitle>The Journal of Infectious Diseases</addtitle><description>A CCTTT microsatellite repeat in the inducible nitric oxide synthase (iNOS) promoter was analyzed among 256 adult patients with severe Plasmodium falciparum malaria and 179 adult patients with mild malaria living in northwestern Thailand. Genotypes with longer forms of the CCTTT repeat (alleles of ⩾15 repeats) were significantly associated with severe malaria (odds ratio [OR], 2.14; P=.0029, χ2 test). More interestingly, the summed repeat number of both microsatellite alleles in an individual was found to be a significant risk factor for severe malaria (OR, 1.11; logistic regression analysis, P=.0041). The single nucleotide substitution, −954G→C, in the iNOS promoter was rare in Thai patients with malaria. No variations were detected in the iNOS promoter region containing functional NF-κB elements at −5.2, −5.5, −5.8, and −6.1 kb upstream of the iNOS transcriptional start site. Thus, a CCTTT repeat in the iNOS promoter may play a key role in the pathogenesis of severe malaria</description><subject>Adult</subject><subject>Alleles</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Cerebral malaria</subject><subject>Concise Communication</subject><subject>Gene Frequency</subject><subject>Genetic Variation</subject><subject>Human protozoal diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Logistic regression</subject><subject>Malaria</subject><subject>Malaria, Cerebral - genetics</subject><subject>Malaria, Cerebral - parasitology</subject><subject>Malaria, Cerebral - physiopathology</subject><subject>Malaria, Falciparum - genetics</subject><subject>Malaria, Falciparum - parasitology</subject><subject>Malaria, Falciparum - physiopathology</subject><subject>Medical sciences</subject><subject>Microsatellite repeats</subject><subject>Microsatellite Repeats - genetics</subject><subject>Microsatellites</subject><subject>NF-kappa B - genetics</subject><subject>Nitric Oxide Synthase - chemistry</subject><subject>Nitric Oxide Synthase - genetics</subject><subject>Nitric Oxide Synthase - metabolism</subject><subject>Nitric Oxide Synthase Type II</subject><subject>Oxides</subject><subject>Parasitic diseases</subject><subject>Plasmodium falciparum - pathogenicity</subject><subject>Polymerase chain reaction</subject><subject>Polymorphism, Genetic</subject><subject>Promoter regions</subject><subject>Promoter Regions, Genetic - genetics</subject><subject>Protozoal diseases</subject><subject>Risk Factors</subject><subject>Severity of Illness Index</subject><subject>Thailand</subject><subject>Tropical medicine</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV2L1DAUhoso7rrqP1CioHfVpGnzcbkU9wNmXXFGEG_CaXu6k7GTjEmqu3_E32uHGXZAEK-S8D484Zw3y54z-o5RJd7zkkmpH2THrOIyF4Lxh9kxpUWRM6X1UfYkxhWltORCPs6OWMF0xTU9zn7P7Y2zvW3BJXIao28tJOsd8T2ZeXeDgZz5sI7bd10vFgtyZdvgIyQcBpuQfMYNQiLWkbREcum6sbXNgOSjTcG25PrWdkjmdy4tISL5FPzap0n6y6YlmeNPDEiuYIBgYetYLMEO4Lqn2aMehojP9udJ9uXsw6K-yGfX55f16SxvS8VS3omq4axRoPR0ZSg6FEJRJjkVUiCjPQKUfaN6hRoV9OUEVayihYJSNZKfZG933k3wP0aMyaxtbKfRwKEfo5EF5VQV6r8gU5JyrfUEvv4LXPkxuGkIUxRcaVlwfrBtVxkD9mYT7BrCnWHUbPs0uz4n8OXeNjZr7A7YvsAJeLMHILYw9AFca-OB46rkkm1Fr3acHzf__uzFjlnF5MM9xSlVZanZlOe73MaEt_c5hO9GSC4rc_H1m9GlqOs5PTcF_wOQKsl5</recordid><startdate>20020815</startdate><enddate>20020815</enddate><creator>Ohashi, Jun</creator><creator>Naka, Izumi</creator><creator>Patarapotikul, Jintana</creator><creator>Hananantachai, Hathairad</creator><creator>Looareesuwan, Sornchai</creator><creator>Tokunaga, Katsushi</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>20020815</creationdate><title>Significant Association of Longer Forms of CCTTT Microsatellite Repeat in the Inducible Nitric Oxide Synthase Promoter with Severe Malaria in Thailand</title><author>Ohashi, Jun ; Naka, Izumi ; Patarapotikul, Jintana ; Hananantachai, Hathairad ; Looareesuwan, Sornchai ; Tokunaga, Katsushi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-d65b31b8a89d651e6de66801730676e10feaa4fb8f8e9e8af451e515028a48b73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Alleles</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>Cerebral malaria</topic><topic>Concise Communication</topic><topic>Gene Frequency</topic><topic>Genetic Variation</topic><topic>Human protozoal diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Logistic regression</topic><topic>Malaria</topic><topic>Malaria, Cerebral - genetics</topic><topic>Malaria, Cerebral - parasitology</topic><topic>Malaria, Cerebral - physiopathology</topic><topic>Malaria, Falciparum - genetics</topic><topic>Malaria, Falciparum - parasitology</topic><topic>Malaria, Falciparum - physiopathology</topic><topic>Medical sciences</topic><topic>Microsatellite repeats</topic><topic>Microsatellite Repeats - genetics</topic><topic>Microsatellites</topic><topic>NF-kappa B - genetics</topic><topic>Nitric Oxide Synthase - chemistry</topic><topic>Nitric Oxide Synthase - genetics</topic><topic>Nitric Oxide Synthase - metabolism</topic><topic>Nitric Oxide Synthase Type II</topic><topic>Oxides</topic><topic>Parasitic diseases</topic><topic>Plasmodium falciparum - pathogenicity</topic><topic>Polymerase chain reaction</topic><topic>Polymorphism, Genetic</topic><topic>Promoter regions</topic><topic>Promoter Regions, Genetic - genetics</topic><topic>Protozoal diseases</topic><topic>Risk Factors</topic><topic>Severity of Illness Index</topic><topic>Thailand</topic><topic>Tropical medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ohashi, Jun</creatorcontrib><creatorcontrib>Naka, Izumi</creatorcontrib><creatorcontrib>Patarapotikul, Jintana</creatorcontrib><creatorcontrib>Hananantachai, Hathairad</creatorcontrib><creatorcontrib>Looareesuwan, Sornchai</creatorcontrib><creatorcontrib>Tokunaga, Katsushi</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ohashi, Jun</au><au>Naka, Izumi</au><au>Patarapotikul, Jintana</au><au>Hananantachai, Hathairad</au><au>Looareesuwan, Sornchai</au><au>Tokunaga, Katsushi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Significant Association of Longer Forms of CCTTT Microsatellite Repeat in the Inducible Nitric Oxide Synthase Promoter with Severe Malaria in Thailand</atitle><jtitle>The Journal of infectious diseases</jtitle><stitle>The Journal of Infectious Diseases</stitle><addtitle>The Journal of Infectious Diseases</addtitle><date>2002-08-15</date><risdate>2002</risdate><volume>186</volume><issue>4</issue><spage>578</spage><epage>581</epage><pages>578-581</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>A CCTTT microsatellite repeat in the inducible nitric oxide synthase (iNOS) promoter was analyzed among 256 adult patients with severe Plasmodium falciparum malaria and 179 adult patients with mild malaria living in northwestern Thailand. Genotypes with longer forms of the CCTTT repeat (alleles of ⩾15 repeats) were significantly associated with severe malaria (odds ratio [OR], 2.14; P=.0029, χ2 test). More interestingly, the summed repeat number of both microsatellite alleles in an individual was found to be a significant risk factor for severe malaria (OR, 1.11; logistic regression analysis, P=.0041). The single nucleotide substitution, −954G→C, in the iNOS promoter was rare in Thai patients with malaria. No variations were detected in the iNOS promoter region containing functional NF-κB elements at −5.2, −5.5, −5.8, and −6.1 kb upstream of the iNOS transcriptional start site. Thus, a CCTTT repeat in the iNOS promoter may play a key role in the pathogenesis of severe malaria</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>12195390</pmid><doi>10.1086/341779</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Alleles Animals Biological and medical sciences Blood Cerebral malaria Concise Communication Gene Frequency Genetic Variation Human protozoal diseases Humans Infectious diseases Logistic regression Malaria Malaria, Cerebral - genetics Malaria, Cerebral - parasitology Malaria, Cerebral - physiopathology Malaria, Falciparum - genetics Malaria, Falciparum - parasitology Malaria, Falciparum - physiopathology Medical sciences Microsatellite repeats Microsatellite Repeats - genetics Microsatellites NF-kappa B - genetics Nitric Oxide Synthase - chemistry Nitric Oxide Synthase - genetics Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type II Oxides Parasitic diseases Plasmodium falciparum - pathogenicity Polymerase chain reaction Polymorphism, Genetic Promoter regions Promoter Regions, Genetic - genetics Protozoal diseases Risk Factors Severity of Illness Index Thailand Tropical medicine |
| title | Significant Association of Longer Forms of CCTTT Microsatellite Repeat in the Inducible Nitric Oxide Synthase Promoter with Severe Malaria in Thailand |
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