An immunophenotypic comparison of metanephric metaplasia of Bowman capsular epithelium with metanephric adenoma, Wilms tumor, and renal development: A case report and review of the literature
Metanephric metaplasia of the parietal epithelium of the Bowman capsule is a rare pathologic finding of unknown pathogenesis that has occurred in patients with widespread malignant neoplasms of various types. We report this finding in a 25-year-old woman with partial expression of the Carney triad w...
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| Veröffentlicht in: | American journal of clinical pathology 2004-06, Vol.121 (6), p.850-856 |
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| container_title | American journal of clinical pathology |
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| creator | FISCHER, Edgar G CARNEY, J. Aidan ANDERSON, Scott R KLATT, Edward C LAGER, Donna J |
| description | Metanephric metaplasia of the parietal epithelium of the Bowman capsule is a rare pathologic finding of unknown pathogenesis that has occurred in patients with widespread malignant neoplasms of various types. We report this finding in a 25-year-old woman with partial expression of the Carney triad who died of a disseminated gastrointestinal stromal tumor, specifically a gastric stromal sarcoma. The metaplasia involved both kidneys diffusely. It originated in the parietal epithelium of the Bowman capsule, extended into the proximal tubules, and focally surrounded the glomeruli in a semicircular manner Immunohistochemical analysis revealed that the cells of metanephric metaplasia expressed the Wilms tumor gene product, bcl-2 protein, and CD57 and cytokeratin 7 and keratin AE1/AE3 focally, but not CD56. This immunophenotype parallels that of metanephric adenoma, Wilms tumor, and nephrogenic rests and overlaps with antigen expression in certain periods of renal development. |
| doi_str_mv | 10.1309/RCT9FVUMVN2UC2HB |
| format | Article |
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This immunophenotype parallels that of metanephric adenoma, Wilms tumor, and nephrogenic rests and overlaps with antigen expression in certain periods of renal development.</description><identifier>ISSN: 0002-9173</identifier><identifier>EISSN: 1943-7722</identifier><identifier>DOI: 10.1309/RCT9FVUMVN2UC2HB</identifier><identifier>PMID: 15198357</identifier><identifier>CODEN: AJCPAI</identifier><language>eng</language><publisher>Chicago, IL: American Society of Clinical Pathologists</publisher><subject>Adenoma - metabolism ; Adenoma - pathology ; Adult ; Biological and medical sciences ; Epithelium - metabolism ; Epithelium - pathology ; Female ; Gastrointestinal Neoplasms - pathology ; General aspects ; Humans ; Immunohistochemistry ; Immunophenotyping ; Kidney - growth & development ; Kidney Neoplasms - metabolism ; Kidney Neoplasms - pathology ; Kidneys ; Medical sciences ; Metaplasia - metabolism ; Metaplasia - pathology ; Neoplasms, Multiple Primary - pathology ; Nephrology. 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It originated in the parietal epithelium of the Bowman capsule, extended into the proximal tubules, and focally surrounded the glomeruli in a semicircular manner Immunohistochemical analysis revealed that the cells of metanephric metaplasia expressed the Wilms tumor gene product, bcl-2 protein, and CD57 and cytokeratin 7 and keratin AE1/AE3 focally, but not CD56. This immunophenotype parallels that of metanephric adenoma, Wilms tumor, and nephrogenic rests and overlaps with antigen expression in certain periods of renal development.</description><subject>Adenoma - metabolism</subject><subject>Adenoma - pathology</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Epithelium - metabolism</subject><subject>Epithelium - pathology</subject><subject>Female</subject><subject>Gastrointestinal Neoplasms - pathology</subject><subject>General aspects</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Immunophenotyping</subject><subject>Kidney - growth & development</subject><subject>Kidney Neoplasms - metabolism</subject><subject>Kidney Neoplasms - pathology</subject><subject>Kidneys</subject><subject>Medical sciences</subject><subject>Metaplasia - metabolism</subject><subject>Metaplasia - pathology</subject><subject>Neoplasms, Multiple Primary - pathology</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Sarcoma - pathology</subject><subject>Tumors</subject><subject>Tumors of the urinary system</subject><subject>Wilms Tumor - metabolism</subject><subject>Wilms Tumor - pathology</subject><issn>0002-9173</issn><issn>1943-7722</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtvFDEQhC0EIkvgzgn5AqcM2J6nuW1WhCAFkFA2HEdeu0dr5FdsT1b5dfw1vMpIPC6c3FJ_VaV2IfSSkre0Jvzdt801v7jZfr75wrYbdnn-CK0ob-qq7xl7jFaEEFZx2tcn6FlKPwihbCDNU3RCW8qHuu1X6OfaYW3t7HzYg_P5PmiJpbdBRJ28w37CFrJwEPaxbI5zMCJpcdyc-4MVDksR0mxExBB03oPRs8WHMv2lFKrYW3GGv2tjE86z9fEMC6dwBCcMVnAHxgcLLr_H6-KZoGyCj3mB7jQcjqElARudIYo8R3iOnkzCJHixvKdoe_HhenNZXX39-Gmzvqpk-adccQZtsyPAdkMLisq6nWTTdT2XnRTDoCRVXcNpC_0kyTQpyWVbKzKQXUMV7Zr6FL158A3R386Q8mh1kmBMOdDPaewZqUlD2X9BylvelegCkgdQRp9ShGkMUVsR70dKxmO747_tFsmrxXveWVC_BUudBXi9ACJJYaYonNTpD67vBsL6-heQdrOv</recordid><startdate>20040601</startdate><enddate>20040601</enddate><creator>FISCHER, Edgar G</creator><creator>CARNEY, J. 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Aidan</au><au>ANDERSON, Scott R</au><au>KLATT, Edward C</au><au>LAGER, Donna J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An immunophenotypic comparison of metanephric metaplasia of Bowman capsular epithelium with metanephric adenoma, Wilms tumor, and renal development: A case report and review of the literature</atitle><jtitle>American journal of clinical pathology</jtitle><addtitle>Am J Clin Pathol</addtitle><date>2004-06-01</date><risdate>2004</risdate><volume>121</volume><issue>6</issue><spage>850</spage><epage>856</epage><pages>850-856</pages><issn>0002-9173</issn><eissn>1943-7722</eissn><coden>AJCPAI</coden><abstract>Metanephric metaplasia of the parietal epithelium of the Bowman capsule is a rare pathologic finding of unknown pathogenesis that has occurred in patients with widespread malignant neoplasms of various types. We report this finding in a 25-year-old woman with partial expression of the Carney triad who died of a disseminated gastrointestinal stromal tumor, specifically a gastric stromal sarcoma. The metaplasia involved both kidneys diffusely. It originated in the parietal epithelium of the Bowman capsule, extended into the proximal tubules, and focally surrounded the glomeruli in a semicircular manner Immunohistochemical analysis revealed that the cells of metanephric metaplasia expressed the Wilms tumor gene product, bcl-2 protein, and CD57 and cytokeratin 7 and keratin AE1/AE3 focally, but not CD56. This immunophenotype parallels that of metanephric adenoma, Wilms tumor, and nephrogenic rests and overlaps with antigen expression in certain periods of renal development.</abstract><cop>Chicago, IL</cop><pub>American Society of Clinical Pathologists</pub><pmid>15198357</pmid><doi>10.1309/RCT9FVUMVN2UC2HB</doi><tpages>7</tpages></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adenoma - metabolism Adenoma - pathology Adult Biological and medical sciences Epithelium - metabolism Epithelium - pathology Female Gastrointestinal Neoplasms - pathology General aspects Humans Immunohistochemistry Immunophenotyping Kidney - growth & development Kidney Neoplasms - metabolism Kidney Neoplasms - pathology Kidneys Medical sciences Metaplasia - metabolism Metaplasia - pathology Neoplasms, Multiple Primary - pathology Nephrology. Urinary tract diseases Sarcoma - pathology Tumors Tumors of the urinary system Wilms Tumor - metabolism Wilms Tumor - pathology |
| title | An immunophenotypic comparison of metanephric metaplasia of Bowman capsular epithelium with metanephric adenoma, Wilms tumor, and renal development: A case report and review of the literature |
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