Parenteral emulsions stabilized with a mixture of phospholipids and PEG-660-12-hydroxy-stearate: evaluation of accelerated and long-term stability

Different emulsion formulations were prepared using phospholipids (Lipoid S57) and PEG-660-12-hydroxy-stearate (Solutol HS15) as single emulsifiers or in mixtures. The accelerated stability after autoclaving, freezing and centrifugation was investigated. The long-term stability was also studied at d...

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Veröffentlicht in:	European journal of pharmaceutics and biopharmaceutics 2002-09, Vol.54 (2), p.207-212
Hauptverfasser:	Jumaa, Muhannad, Müller, Bernd W
Format:	Artikel
Sprache:	eng
Schlagworte:	Accelerated stability Biological and medical sciences Centrifugation Chemistry, Pharmaceutical Drug Compounding Drug Stability Emulsifier mixture Emulsions Excipients - chemistry Freezing General pharmacology Hot Temperature Infusions, Parenteral Lipid emulsion Long-term stability Medical sciences PEG-660-12-hydroxy-stearate Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Phospholipids Phospholipids - chemistry Polyethylene Glycols - chemistry Stearates - chemistry Surface-Active Agents - chemistry Time Factors
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