Preparation and characterization of propranolol hydrochloride nanoparticles: a comparative study
The water-in-oil-in-water (w/o/w) emulsification process is the method of choice for the encapsulation inside polymeric particles of hydrophilic drugs such as proteins and peptides which are high molecular weight macromolecules. Our objective was to apply this technique in order to formulate nanopar...
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| Veröffentlicht in: | Journal of controlled release 2004-06, Vol.97 (2), p.291-300 |
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| creator | Ubrich, Nathalie Bouillot, Philippe Pellerin, Christina Hoffman, Maurice Maincent, Philippe |
| description | The water-in-oil-in-water (w/o/w) emulsification process is the method of choice for the encapsulation inside polymeric particles of hydrophilic drugs such as proteins and peptides which are high molecular weight macromolecules. Our objective was to apply this technique in order to formulate nanoparticles loaded with both a hydrophilic and a low molecular weight drug such as propranolol-HCl. Nanoparticles were prepared using a pressure homogenization device with various polymers (poly-ε-caprolactone, poly(lactide-co-glycolide), ethylcellulose) and different amounts of drug and were compared in terms of particle size, encapsulation efficiency and drug release. Higher encapsulation efficiencies were obtained with both PCL (77.3%) and PLGA (83.3%) compared to ethylcellulose (66.8%). The in vitro drug release was characterized by an initial burst and an incomplete dissolution of the drug. When decreasing the polymer/drug ratio, the release appeared more controlled and prolonged up to 8 h. It can be concluded that nanoparticles prepared by w/o/w emulsification followed by solvent evaporation might be potential drug carriers for low molecular weight and hydrophilic drugs. |
| doi_str_mv | 10.1016/j.jconrel.2004.03.023 |
| format | Article |
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Drug treatments ; Polyesters - chemistry ; Polyglactin 910 - chemistry ; Polymers - chemistry ; Propranolol - chemistry ; Propranolol hydrochloride ; Solubility ; Time Factors ; w/o/w emulsion ; Water - chemistry</subject><ispartof>Journal of controlled release, 2004-06, Vol.97 (2), p.291-300</ispartof><rights>2004 Elsevier B.V.</rights><rights>2004 INIST-CNRS</rights><rights>Copyright 2004 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-18d89be6bc460163b1f3a5b628938c259c41a9e4c6a34acd8d4263df29c5757b3</citedby><cites>FETCH-LOGICAL-c422t-18d89be6bc460163b1f3a5b628938c259c41a9e4c6a34acd8d4263df29c5757b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jconrel.2004.03.023$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15854476$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15196756$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ubrich, Nathalie</creatorcontrib><creatorcontrib>Bouillot, Philippe</creatorcontrib><creatorcontrib>Pellerin, Christina</creatorcontrib><creatorcontrib>Hoffman, Maurice</creatorcontrib><creatorcontrib>Maincent, Philippe</creatorcontrib><title>Preparation and characterization of propranolol hydrochloride nanoparticles: a comparative study</title><title>Journal of controlled release</title><addtitle>J Control Release</addtitle><description>The water-in-oil-in-water (w/o/w) emulsification process is the method of choice for the encapsulation inside polymeric particles of hydrophilic drugs such as proteins and peptides which are high molecular weight macromolecules. Our objective was to apply this technique in order to formulate nanoparticles loaded with both a hydrophilic and a low molecular weight drug such as propranolol-HCl. Nanoparticles were prepared using a pressure homogenization device with various polymers (poly-ε-caprolactone, poly(lactide-co-glycolide), ethylcellulose) and different amounts of drug and were compared in terms of particle size, encapsulation efficiency and drug release. Higher encapsulation efficiencies were obtained with both PCL (77.3%) and PLGA (83.3%) compared to ethylcellulose (66.8%). The in vitro drug release was characterized by an initial burst and an incomplete dissolution of the drug. When decreasing the polymer/drug ratio, the release appeared more controlled and prolonged up to 8 h. It can be concluded that nanoparticles prepared by w/o/w emulsification followed by solvent evaporation might be potential drug carriers for low molecular weight and hydrophilic drugs.</description><subject>Biological and medical sciences</subject><subject>Calorimetry, Differential Scanning</subject><subject>Cellulose - analogs & derivatives</subject><subject>Cellulose - chemistry</subject><subject>Chemistry, Pharmaceutical</subject><subject>Drug Compounding</subject><subject>Emulsions</subject><subject>Excipients - chemistry</subject><subject>General pharmacology</subject><subject>Hydrophilic drug</subject><subject>Low molecular weight drug</subject><subject>Medical sciences</subject><subject>Nanoparticle</subject><subject>Nanostructures</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Polyesters - chemistry</subject><subject>Polyglactin 910 - chemistry</subject><subject>Polymers - chemistry</subject><subject>Propranolol - chemistry</subject><subject>Propranolol hydrochloride</subject><subject>Solubility</subject><subject>Time Factors</subject><subject>w/o/w emulsion</subject><subject>Water - chemistry</subject><issn>0168-3659</issn><issn>1873-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9v1DAQxS0EokvpRwDlQm8J_p-YC0JVKUiV4ABn1xlPtF5l48XOVlo-PV4lEr31ZM3o98ZP7xHyjtGGUaY_7podxCnh2HBKZUNFQ7l4QTasa0UtjVEvyaZwXS20MhfkTc47SqkSsn1NLphiRrdKb8jDz4QHl9wc4lS5yVewLRPMmMLfZRmH6pDiIbkpjnGstiefImzHmILHairbIp8DjJg_Va6CuF_OPWKV56M_vSWvBjdmvFrfS_L76-2vm2_1_Y-77zdf7muQnM8163xnetQ9SF1si54Nwqle886IDrgyIJkzKEE7IR34zkuuhR-4AdWqtheX5Hq5W8z-OWKe7T5kwHF0E8Zjti2n3AjGngVZWwwwxQuoFhBSzDnhYA8p7F06WUbtuQO7s2sH9tyBpcKWDoru_frBsd-j_69aQy_AhxVwGdw4lGgh5Cdcp6Rsz9znhcOS22PAZDMEnAB9SAiz9TE8Y-Uf6BGpcQ</recordid><startdate>20040618</startdate><enddate>20040618</enddate><creator>Ubrich, Nathalie</creator><creator>Bouillot, Philippe</creator><creator>Pellerin, Christina</creator><creator>Hoffman, Maurice</creator><creator>Maincent, Philippe</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20040618</creationdate><title>Preparation and characterization of propranolol hydrochloride nanoparticles: a comparative study</title><author>Ubrich, Nathalie ; Bouillot, Philippe ; Pellerin, Christina ; Hoffman, Maurice ; Maincent, Philippe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-18d89be6bc460163b1f3a5b628938c259c41a9e4c6a34acd8d4263df29c5757b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Biological and medical sciences</topic><topic>Calorimetry, Differential Scanning</topic><topic>Cellulose - analogs & derivatives</topic><topic>Cellulose - chemistry</topic><topic>Chemistry, Pharmaceutical</topic><topic>Drug Compounding</topic><topic>Emulsions</topic><topic>Excipients - chemistry</topic><topic>General pharmacology</topic><topic>Hydrophilic drug</topic><topic>Low molecular weight drug</topic><topic>Medical sciences</topic><topic>Nanoparticle</topic><topic>Nanostructures</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Polyesters - chemistry</topic><topic>Polyglactin 910 - chemistry</topic><topic>Polymers - chemistry</topic><topic>Propranolol - chemistry</topic><topic>Propranolol hydrochloride</topic><topic>Solubility</topic><topic>Time Factors</topic><topic>w/o/w emulsion</topic><topic>Water - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ubrich, Nathalie</creatorcontrib><creatorcontrib>Bouillot, Philippe</creatorcontrib><creatorcontrib>Pellerin, Christina</creatorcontrib><creatorcontrib>Hoffman, Maurice</creatorcontrib><creatorcontrib>Maincent, Philippe</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of controlled release</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ubrich, Nathalie</au><au>Bouillot, Philippe</au><au>Pellerin, Christina</au><au>Hoffman, Maurice</au><au>Maincent, Philippe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preparation and characterization of propranolol hydrochloride nanoparticles: a comparative study</atitle><jtitle>Journal of controlled release</jtitle><addtitle>J Control Release</addtitle><date>2004-06-18</date><risdate>2004</risdate><volume>97</volume><issue>2</issue><spage>291</spage><epage>300</epage><pages>291-300</pages><issn>0168-3659</issn><eissn>1873-4995</eissn><coden>JCREEC</coden><abstract>The water-in-oil-in-water (w/o/w) emulsification process is the method of choice for the encapsulation inside polymeric particles of hydrophilic drugs such as proteins and peptides which are high molecular weight macromolecules. Our objective was to apply this technique in order to formulate nanoparticles loaded with both a hydrophilic and a low molecular weight drug such as propranolol-HCl. Nanoparticles were prepared using a pressure homogenization device with various polymers (poly-ε-caprolactone, poly(lactide-co-glycolide), ethylcellulose) and different amounts of drug and were compared in terms of particle size, encapsulation efficiency and drug release. Higher encapsulation efficiencies were obtained with both PCL (77.3%) and PLGA (83.3%) compared to ethylcellulose (66.8%). The in vitro drug release was characterized by an initial burst and an incomplete dissolution of the drug. When decreasing the polymer/drug ratio, the release appeared more controlled and prolonged up to 8 h. 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| subjects | Biological and medical sciences Calorimetry, Differential Scanning Cellulose - analogs & derivatives Cellulose - chemistry Chemistry, Pharmaceutical Drug Compounding Emulsions Excipients - chemistry General pharmacology Hydrophilic drug Low molecular weight drug Medical sciences Nanoparticle Nanostructures Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polyesters - chemistry Polyglactin 910 - chemistry Polymers - chemistry Propranolol - chemistry Propranolol hydrochloride Solubility Time Factors w/o/w emulsion Water - chemistry |
| title | Preparation and characterization of propranolol hydrochloride nanoparticles: a comparative study |
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