Midodrine prescribed to improve recurrent post-spaceflight orthostatic hypotension

Many astronauts exhibit post-spaceflight orthostatic hypotension due to inadequate norepinephrine release when in an upright posture. We hypothesized that an alpha1-adrenergic agonist, midodrine, would be an effective countermeasure. A female astronaut, who had problems with postflight orthostatic h...

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Veröffentlicht in:	Aviation, space, and environmental medicine space, and environmental medicine, 2004-06, Vol.75 (6), p.554-556
Hauptverfasser:	Platts, Steven H, Ziegler, Michael G, Waters, Wendy W, Mitchell, Brett M, Meck, Janice V
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic alpha-Agonists - pharmacology Adrenergic alpha-Agonists - therapeutic use Cardiac Output - drug effects Female Heart Rate Humans Hypotension, Orthostatic - drug therapy Midodrine - pharmacology Midodrine - therapeutic use Recurrence Space Flight Space life sciences Stroke Volume - drug effects
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