SAR by MS:  A Ligand Based Technique for Drug Lead Discovery Against Structured RNA Targets

A technique for lead discovery vs RNA targets utilizing mass spectrometry (MS) screening methods is described. The structure−activity relationships (SAR) derived from assaying weak binding motifs allows the pharmacophores discovered to be elaborated via “SAR by MS” to higher affinity ligands. Applic...

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Veröffentlicht in:	Journal of medicinal chemistry 2002-08, Vol.45 (18), p.3816-3819
Hauptverfasser:	Swayze, Eric E, Jefferson, Elizabeth A, Sannes-Lowery, Kristin A, Blyn, Lawrence B, Risen, Lisa M, Arakawa, Satoshi, Osgood, Stephen A, Hofstadler, Steven A, Griffey, Richard H
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - chemistry Biological and medical sciences Ligands Mass Spectrometry Medical sciences Miscellaneous Pharmacology. Drug treatments Quantitative Structure-Activity Relationship Quinoxalines - chemistry RNA - chemistry Stereoisomerism
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