Mapping spatio‐temporal activation of Notch signaling during neurogenesis and gliogenesis in the developing mouse brain

Notch1 plays various important roles including the maintenance of the stem cell state as well as the promotion of glial fates in mammalian CNS development. However, because of the very low amount of the activated form of Notch1 present in vivo, its precise activation pattern has remained unknown. In...

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Veröffentlicht in:	Journal of neurochemistry 2004-07, Vol.90 (1), p.142-154
Hauptverfasser:	Tokunaga, Akinori, Kohyama, Jun, Yoshida, Tetsu, Nakao, Keiko, Sawamoto, Kazunobu, Okano, Hideyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	activated Notch1 Animals Animals, Newborn Antibody Specificity Basic Helix-Loop-Helix Transcription Factors Biological and medical sciences Brain - cytology Brain - embryology Brain - metabolism Cell Differentiation - physiology Cell physiology Development. Senescence. Regeneration. Transplantation DNA-Binding Proteins - biosynthesis Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Developmental gliogenesis Immunohistochemistry Mash1 Mice Mice, Inbred C57BL Molecular and cellular biology Nerve Tissue Proteins - biosynthesis neurogenesis neurogenin2 Neuroglia - cytology Neuroglia - metabolism Neurons - cytology Neurons - metabolism NIH 3T3 Cells radial glia Receptor, Notch1 Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Sensitivity and Specificity Signal transduction Signal Transduction - physiology Stem Cells - cytology Stem Cells - metabolism Transcription Factors - biosynthesis Vertebrates: nervous system and sense organs
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