Fighting colorectal cancer: molecular epidemiology differences among Ashkenazi and Sephardic Jews and Palestinians
Background: To evaluate and compare differences in the molecular genetics among high-risk (Ashkenazi Jews), intermediate-risk (Sephardic Jews) and low-risk (Palestinians) groups for colorectal cancer who live in the same geographical region. Patients and methods: The 1995–1996 records from the Tel A...
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| Veröffentlicht in: | Annals of oncology 2002-09, Vol.13 (9), p.1497-1501 |
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| creator | Darwish, H. Trejo, I. E. Shapira, I. Oweineh, S. Sughayer, M. Baron, L. Aljadeff, E. Silbermann, M. Sweidan, W. Zilberg, D. Halpern, Z. Hibshoosh, H. Arber, N. |
| description | Background: To evaluate and compare differences in the molecular genetics among high-risk (Ashkenazi Jews), intermediate-risk (Sephardic Jews) and low-risk (Palestinians) groups for colorectal cancer who live in the same geographical region. Patients and methods: The 1995–1996 records from the Tel Aviv Medical Center and Muqased hospital (East Jerusalem) randomly identified patients with colorectal cancer. There were 25 patients from each ethnic group. Epidemiological data were obtained from interviews with the patients and from their hospital charts. The levels of cyclin D1, β-catenine, p27, p53, Ki-67 and Her-2/neu proteins were determined by immunohistochemistry. The main outcome measures were the association between gene expression and colorectal incidence in the different ethnic groups. Results: Ashkenazi Jews have the highest rate of colorectal cancer, and are diagnosed at an early stage compared with Palestinians (72% and 33% of the cases are in Dukes’ A and B, respectively), and, hence, this may explain the better 5-year survival rate among this group. Sephardic Jews are diagnosed at a more advanced stage, the tumors are poorly differentiated and they lack p27. Palestinians have significantly higher cyclin D1 levels. There was a statistically significant inverse correlation between the expression of β-catenine and cyclin D1, as well as p53 and p27 (P |
| doi_str_mv | 10.1093/annonc/mdf230 |
| format | Article |
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E. ; Shapira, I. ; Oweineh, S. ; Sughayer, M. ; Baron, L. ; Aljadeff, E. ; Silbermann, M. ; Sweidan, W. ; Zilberg, D. ; Halpern, Z. ; Hibshoosh, H. ; Arber, N.</creator><creatorcontrib>Darwish, H. ; Trejo, I. E. ; Shapira, I. ; Oweineh, S. ; Sughayer, M. ; Baron, L. ; Aljadeff, E. ; Silbermann, M. ; Sweidan, W. ; Zilberg, D. ; Halpern, Z. ; Hibshoosh, H. ; Arber, N.</creatorcontrib><description>Background: To evaluate and compare differences in the molecular genetics among high-risk (Ashkenazi Jews), intermediate-risk (Sephardic Jews) and low-risk (Palestinians) groups for colorectal cancer who live in the same geographical region. Patients and methods: The 1995–1996 records from the Tel Aviv Medical Center and Muqased hospital (East Jerusalem) randomly identified patients with colorectal cancer. There were 25 patients from each ethnic group. Epidemiological data were obtained from interviews with the patients and from their hospital charts. The levels of cyclin D1, β-catenine, p27, p53, Ki-67 and Her-2/neu proteins were determined by immunohistochemistry. The main outcome measures were the association between gene expression and colorectal incidence in the different ethnic groups. Results: Ashkenazi Jews have the highest rate of colorectal cancer, and are diagnosed at an early stage compared with Palestinians (72% and 33% of the cases are in Dukes’ A and B, respectively), and, hence, this may explain the better 5-year survival rate among this group. Sephardic Jews are diagnosed at a more advanced stage, the tumors are poorly differentiated and they lack p27. Palestinians have significantly higher cyclin D1 levels. There was a statistically significant inverse correlation between the expression of β-catenine and cyclin D1, as well as p53 and p27 (P <0.05). Conclusions: Increased expression of cyclin D1, p53, Ki-67, β-catenine and Her-2/neu, and decreased expression of p27 may be important events in the three ethnic groups with colorectal cancer. The lower mortality rate among Ashkenazi Jews may be partially explained by their better molecular biology profile.</description><identifier>ISSN: 0923-7534</identifier><identifier>EISSN: 1569-8041</identifier><identifier>DOI: 10.1093/annonc/mdf230</identifier><identifier>PMID: 12196377</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Aged ; Aged, 80 and over ; Arabs - genetics ; beta Catenin ; Biological and medical sciences ; Biopsy, Needle ; colorectal cancer ; Colorectal Neoplasms - ethnology ; Colorectal Neoplasms - genetics ; Colorectal Neoplasms - prevention & control ; Cyclin D1 - genetics ; Cytoskeletal Proteins - genetics ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Genes, p53 - genetics ; Genetic Markers - genetics ; Genetic Predisposition to Disease - ethnology ; Humans ; Immunohistochemistry ; Israel - epidemiology ; Jews - genetics ; Key words: Ashkenazi Jews ; Ki-67 Antigen - genetics ; Male ; Medical sciences ; Middle Aged ; Molecular Epidemiology ; Palestinians ; Receptor, ErbB-2 - genetics ; Registries ; Retrospective Studies ; Sensitivity and Specificity ; Sephardic Jews ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Trans-Activators - genetics ; Tumors</subject><ispartof>Annals of oncology, 2002-09, Vol.13 (9), p.1497-1501</ispartof><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-a2affc6aecfc5dc78308986f92d03c61baba8bd3e1355f58e83c1335cf6f40ec3</citedby><cites>FETCH-LOGICAL-c396t-a2affc6aecfc5dc78308986f92d03c61baba8bd3e1355f58e83c1335cf6f40ec3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14408243$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12196377$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Darwish, H.</creatorcontrib><creatorcontrib>Trejo, I. E.</creatorcontrib><creatorcontrib>Shapira, I.</creatorcontrib><creatorcontrib>Oweineh, S.</creatorcontrib><creatorcontrib>Sughayer, M.</creatorcontrib><creatorcontrib>Baron, L.</creatorcontrib><creatorcontrib>Aljadeff, E.</creatorcontrib><creatorcontrib>Silbermann, M.</creatorcontrib><creatorcontrib>Sweidan, W.</creatorcontrib><creatorcontrib>Zilberg, D.</creatorcontrib><creatorcontrib>Halpern, Z.</creatorcontrib><creatorcontrib>Hibshoosh, H.</creatorcontrib><creatorcontrib>Arber, N.</creatorcontrib><title>Fighting colorectal cancer: molecular epidemiology differences among Ashkenazi and Sephardic Jews and Palestinians</title><title>Annals of oncology</title><addtitle>Ann Oncol</addtitle><description>Background: To evaluate and compare differences in the molecular genetics among high-risk (Ashkenazi Jews), intermediate-risk (Sephardic Jews) and low-risk (Palestinians) groups for colorectal cancer who live in the same geographical region. Patients and methods: The 1995–1996 records from the Tel Aviv Medical Center and Muqased hospital (East Jerusalem) randomly identified patients with colorectal cancer. There were 25 patients from each ethnic group. Epidemiological data were obtained from interviews with the patients and from their hospital charts. The levels of cyclin D1, β-catenine, p27, p53, Ki-67 and Her-2/neu proteins were determined by immunohistochemistry. The main outcome measures were the association between gene expression and colorectal incidence in the different ethnic groups. Results: Ashkenazi Jews have the highest rate of colorectal cancer, and are diagnosed at an early stage compared with Palestinians (72% and 33% of the cases are in Dukes’ A and B, respectively), and, hence, this may explain the better 5-year survival rate among this group. Sephardic Jews are diagnosed at a more advanced stage, the tumors are poorly differentiated and they lack p27. Palestinians have significantly higher cyclin D1 levels. There was a statistically significant inverse correlation between the expression of β-catenine and cyclin D1, as well as p53 and p27 (P <0.05). Conclusions: Increased expression of cyclin D1, p53, Ki-67, β-catenine and Her-2/neu, and decreased expression of p27 may be important events in the three ethnic groups with colorectal cancer. The lower mortality rate among Ashkenazi Jews may be partially explained by their better molecular biology profile.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Arabs - genetics</subject><subject>beta Catenin</subject><subject>Biological and medical sciences</subject><subject>Biopsy, Needle</subject><subject>colorectal cancer</subject><subject>Colorectal Neoplasms - ethnology</subject><subject>Colorectal Neoplasms - genetics</subject><subject>Colorectal Neoplasms - prevention & control</subject><subject>Cyclin D1 - genetics</subject><subject>Cytoskeletal Proteins - genetics</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Genes, p53 - genetics</subject><subject>Genetic Markers - genetics</subject><subject>Genetic Predisposition to Disease - ethnology</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Israel - epidemiology</subject><subject>Jews - genetics</subject><subject>Key words: Ashkenazi Jews</subject><subject>Ki-67 Antigen - genetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Molecular Epidemiology</subject><subject>Palestinians</subject><subject>Receptor, ErbB-2 - genetics</subject><subject>Registries</subject><subject>Retrospective Studies</subject><subject>Sensitivity and Specificity</subject><subject>Sephardic Jews</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Trans-Activators - genetics</subject><subject>Tumors</subject><issn>0923-7534</issn><issn>1569-8041</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1vEzEQhi0EoqFw5Ir2Arel_lh7bW6lIm1RpRYBAnGxJuNxYrofwU4E5dezJVFzGmnmmfeVHsZeCv5WcKdOYBjGAU_6EKXij9hMaONqyxvxmM24k6putWqO2LNSfnLOjZPuKTsSUjij2nbG8jwtV5s0LCscuzETbqCrEAak_K7qx45w20GuaJ0C9WlClndVSDFSpokpFfTj9HtaVrc0wN9UwRCqz7ReQQ4Jq4_0u_xf3UBHZapJMJTn7EmErtCL_TxmX-cfvpxd1FfX55dnp1c1Kmc2NUiIEQ0QRtQBW6u4ddZEJwNXaMQCFmAXQZFQWkdtySoUSmmMJjacUB2zN7vcdR5_bad636eC1HUw0LgtvpVcWqnlBNY7EPNYSqbo1zn1kO-84P5est9J9jvJE_9qH7xd9BQO9N7qBLzeA1AQupgnn6kcuKbhVjbqUJzKhv483CHfetOqVvuL7z-8ujl__83NP3mt_gGBB5k-</recordid><startdate>20020901</startdate><enddate>20020901</enddate><creator>Darwish, H.</creator><creator>Trejo, I. 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E. ; Shapira, I. ; Oweineh, S. ; Sughayer, M. ; Baron, L. ; Aljadeff, E. ; Silbermann, M. ; Sweidan, W. ; Zilberg, D. ; Halpern, Z. ; Hibshoosh, H. ; Arber, N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-a2affc6aecfc5dc78308986f92d03c61baba8bd3e1355f58e83c1335cf6f40ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Arabs - genetics</topic><topic>beta Catenin</topic><topic>Biological and medical sciences</topic><topic>Biopsy, Needle</topic><topic>colorectal cancer</topic><topic>Colorectal Neoplasms - ethnology</topic><topic>Colorectal Neoplasms - genetics</topic><topic>Colorectal Neoplasms - prevention & control</topic><topic>Cyclin D1 - genetics</topic><topic>Cytoskeletal Proteins - genetics</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Genes, p53 - genetics</topic><topic>Genetic Markers - genetics</topic><topic>Genetic Predisposition to Disease - ethnology</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Israel - epidemiology</topic><topic>Jews - genetics</topic><topic>Key words: Ashkenazi Jews</topic><topic>Ki-67 Antigen - genetics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Molecular Epidemiology</topic><topic>Palestinians</topic><topic>Receptor, ErbB-2 - genetics</topic><topic>Registries</topic><topic>Retrospective Studies</topic><topic>Sensitivity and Specificity</topic><topic>Sephardic Jews</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Trans-Activators - genetics</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Darwish, H.</creatorcontrib><creatorcontrib>Trejo, I. E.</creatorcontrib><creatorcontrib>Shapira, I.</creatorcontrib><creatorcontrib>Oweineh, S.</creatorcontrib><creatorcontrib>Sughayer, M.</creatorcontrib><creatorcontrib>Baron, L.</creatorcontrib><creatorcontrib>Aljadeff, E.</creatorcontrib><creatorcontrib>Silbermann, M.</creatorcontrib><creatorcontrib>Sweidan, W.</creatorcontrib><creatorcontrib>Zilberg, D.</creatorcontrib><creatorcontrib>Halpern, Z.</creatorcontrib><creatorcontrib>Hibshoosh, H.</creatorcontrib><creatorcontrib>Arber, N.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Darwish, H.</au><au>Trejo, I. E.</au><au>Shapira, I.</au><au>Oweineh, S.</au><au>Sughayer, M.</au><au>Baron, L.</au><au>Aljadeff, E.</au><au>Silbermann, M.</au><au>Sweidan, W.</au><au>Zilberg, D.</au><au>Halpern, Z.</au><au>Hibshoosh, H.</au><au>Arber, N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fighting colorectal cancer: molecular epidemiology differences among Ashkenazi and Sephardic Jews and Palestinians</atitle><jtitle>Annals of oncology</jtitle><addtitle>Ann Oncol</addtitle><date>2002-09-01</date><risdate>2002</risdate><volume>13</volume><issue>9</issue><spage>1497</spage><epage>1501</epage><pages>1497-1501</pages><issn>0923-7534</issn><eissn>1569-8041</eissn><abstract>Background: To evaluate and compare differences in the molecular genetics among high-risk (Ashkenazi Jews), intermediate-risk (Sephardic Jews) and low-risk (Palestinians) groups for colorectal cancer who live in the same geographical region. Patients and methods: The 1995–1996 records from the Tel Aviv Medical Center and Muqased hospital (East Jerusalem) randomly identified patients with colorectal cancer. There were 25 patients from each ethnic group. Epidemiological data were obtained from interviews with the patients and from their hospital charts. The levels of cyclin D1, β-catenine, p27, p53, Ki-67 and Her-2/neu proteins were determined by immunohistochemistry. The main outcome measures were the association between gene expression and colorectal incidence in the different ethnic groups. Results: Ashkenazi Jews have the highest rate of colorectal cancer, and are diagnosed at an early stage compared with Palestinians (72% and 33% of the cases are in Dukes’ A and B, respectively), and, hence, this may explain the better 5-year survival rate among this group. Sephardic Jews are diagnosed at a more advanced stage, the tumors are poorly differentiated and they lack p27. Palestinians have significantly higher cyclin D1 levels. There was a statistically significant inverse correlation between the expression of β-catenine and cyclin D1, as well as p53 and p27 (P <0.05). Conclusions: Increased expression of cyclin D1, p53, Ki-67, β-catenine and Her-2/neu, and decreased expression of p27 may be important events in the three ethnic groups with colorectal cancer. The lower mortality rate among Ashkenazi Jews may be partially explained by their better molecular biology profile.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>12196377</pmid><doi>10.1093/annonc/mdf230</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Aged, 80 and over Arabs - genetics beta Catenin Biological and medical sciences Biopsy, Needle colorectal cancer Colorectal Neoplasms - ethnology Colorectal Neoplasms - genetics Colorectal Neoplasms - prevention & control Cyclin D1 - genetics Cytoskeletal Proteins - genetics Female Gastroenterology. Liver. Pancreas. Abdomen Genes, p53 - genetics Genetic Markers - genetics Genetic Predisposition to Disease - ethnology Humans Immunohistochemistry Israel - epidemiology Jews - genetics Key words: Ashkenazi Jews Ki-67 Antigen - genetics Male Medical sciences Middle Aged Molecular Epidemiology Palestinians Receptor, ErbB-2 - genetics Registries Retrospective Studies Sensitivity and Specificity Sephardic Jews Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Trans-Activators - genetics Tumors |
| title | Fighting colorectal cancer: molecular epidemiology differences among Ashkenazi and Sephardic Jews and Palestinians |
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