Pineal-regulating tetrapeptide epitalon improves eye retina condition in retinitis pigmentosa
We have studied the effect of tetrapeptide Epitalon (Ala-Glu-Asp-Gly) on the course of congenital pigmented degeneration of the retina. The application of Epitalon in Campbell rats is found to intensify the bioelectric and functional activity of the retina due to the preservation of its morphologica...
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| Veröffentlicht in: | Neuro-endocrinology letters 2002-08, Vol.23 (4), p.365-368 |
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| container_title | Neuro-endocrinology letters |
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| creator | Khavinson, Vladimir Razumovsky, Michael Trofimova, Svetlana Grigorian, Roman Razumovskaya, Anna |
| description | We have studied the effect of tetrapeptide Epitalon (Ala-Glu-Asp-Gly) on the course of congenital pigmented degeneration of the retina. The application of Epitalon in Campbell rats is found to intensify the bioelectric and functional activity of the retina due to the preservation of its morphological structure. Epitalon therapy in patients with degenerative retinal lesions results in a positive clinical effect in 90% of the cases. The analysis of Epitalon effects suggests that the tetrapeptide participates in the mechanisms of transcription common for the epiphysis and retina. |
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The application of Epitalon in Campbell rats is found to intensify the bioelectric and functional activity of the retina due to the preservation of its morphological structure. Epitalon therapy in patients with degenerative retinal lesions results in a positive clinical effect in 90% of the cases. The analysis of Epitalon effects suggests that the tetrapeptide participates in the mechanisms of transcription common for the epiphysis and retina.</description><identifier>ISSN: 0172-780X</identifier><identifier>PMID: 12195242</identifier><language>eng</language><publisher>Sweden</publisher><subject>Adolescent ; Adult ; Aged ; Animals ; Electric Conductivity ; Electroretinography ; Humans ; Middle Aged ; Oligopeptides - administration & dosage ; Pineal Gland - drug effects ; Rats ; Rats, Inbred Strains ; Retina - pathology ; Retina - physiology ; Retinitis Pigmentosa - drug therapy ; Retinitis Pigmentosa - pathology</subject><ispartof>Neuro-endocrinology letters, 2002-08, Vol.23 (4), p.365-368</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12195242$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khavinson, Vladimir</creatorcontrib><creatorcontrib>Razumovsky, Michael</creatorcontrib><creatorcontrib>Trofimova, Svetlana</creatorcontrib><creatorcontrib>Grigorian, Roman</creatorcontrib><creatorcontrib>Razumovskaya, Anna</creatorcontrib><title>Pineal-regulating tetrapeptide epitalon improves eye retina condition in retinitis pigmentosa</title><title>Neuro-endocrinology letters</title><addtitle>Neuro Endocrinol Lett</addtitle><description>We have studied the effect of tetrapeptide Epitalon (Ala-Glu-Asp-Gly) on the course of congenital pigmented degeneration of the retina. The application of Epitalon in Campbell rats is found to intensify the bioelectric and functional activity of the retina due to the preservation of its morphological structure. Epitalon therapy in patients with degenerative retinal lesions results in a positive clinical effect in 90% of the cases. The analysis of Epitalon effects suggests that the tetrapeptide participates in the mechanisms of transcription common for the epiphysis and retina.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Animals</subject><subject>Electric Conductivity</subject><subject>Electroretinography</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Oligopeptides - administration & dosage</subject><subject>Pineal Gland - drug effects</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Retina - pathology</subject><subject>Retina - physiology</subject><subject>Retinitis Pigmentosa - drug therapy</subject><subject>Retinitis Pigmentosa - pathology</subject><issn>0172-780X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kE9LxDAQxXNQ3HX1K0hO3gJpkjbtURb_wYIeFLxISZtJiaRpTFJhv71ddvf0Zt78GB7vAq1pIRmRNf1aoeuUfihlTcn4FVoVrFgmwdbo-916UI5EGGansvUDzpCjChCy1YAh2Kzc5LEdQ5z-IGHYA46wkAr3k9c228PVH71lSzjYYQSfp6Ru0KVRLsHtSTfo8-nxY_tCdm_Pr9uHHQmMykw6WRpKawXMFCWAqMUSE4zhjRCm6yQXRS-aRgquhZa6r6qKVaZiXIKgJed8g-6Pf5eMvzOk3I429eCc8jDNqZWMspo2B_DuBM7dCLoN0Y4q7ttzIfwfWvhdJQ</recordid><startdate>200208</startdate><enddate>200208</enddate><creator>Khavinson, Vladimir</creator><creator>Razumovsky, Michael</creator><creator>Trofimova, Svetlana</creator><creator>Grigorian, Roman</creator><creator>Razumovskaya, Anna</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200208</creationdate><title>Pineal-regulating tetrapeptide epitalon improves eye retina condition in retinitis pigmentosa</title><author>Khavinson, Vladimir ; Razumovsky, Michael ; Trofimova, Svetlana ; Grigorian, Roman ; Razumovskaya, Anna</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p207t-b75f008ae2f15ee484523eff3944fbb7341c499743d4d7dc66626f6237e405333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Animals</topic><topic>Electric Conductivity</topic><topic>Electroretinography</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Oligopeptides - administration & dosage</topic><topic>Pineal Gland - drug effects</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Retina - pathology</topic><topic>Retina - physiology</topic><topic>Retinitis Pigmentosa - drug therapy</topic><topic>Retinitis Pigmentosa - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khavinson, Vladimir</creatorcontrib><creatorcontrib>Razumovsky, Michael</creatorcontrib><creatorcontrib>Trofimova, Svetlana</creatorcontrib><creatorcontrib>Grigorian, Roman</creatorcontrib><creatorcontrib>Razumovskaya, Anna</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Neuro-endocrinology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khavinson, Vladimir</au><au>Razumovsky, Michael</au><au>Trofimova, Svetlana</au><au>Grigorian, Roman</au><au>Razumovskaya, Anna</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pineal-regulating tetrapeptide epitalon improves eye retina condition in retinitis pigmentosa</atitle><jtitle>Neuro-endocrinology letters</jtitle><addtitle>Neuro Endocrinol Lett</addtitle><date>2002-08</date><risdate>2002</risdate><volume>23</volume><issue>4</issue><spage>365</spage><epage>368</epage><pages>365-368</pages><issn>0172-780X</issn><abstract>We have studied the effect of tetrapeptide Epitalon (Ala-Glu-Asp-Gly) on the course of congenital pigmented degeneration of the retina. 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| ispartof | Neuro-endocrinology letters, 2002-08, Vol.23 (4), p.365-368 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adolescent Adult Aged Animals Electric Conductivity Electroretinography Humans Middle Aged Oligopeptides - administration & dosage Pineal Gland - drug effects Rats Rats, Inbred Strains Retina - pathology Retina - physiology Retinitis Pigmentosa - drug therapy Retinitis Pigmentosa - pathology |
| title | Pineal-regulating tetrapeptide epitalon improves eye retina condition in retinitis pigmentosa |
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