STAT3 activation abrogates growth factor dependence and contributes to head and neck squamous cell carcinoma tumor growth in vivo

Epidermal growth factor receptor (EGFR) is up-regulated and contributes to the loss of growth control in squamous cell carcinoma of the head and neck (SCCHN). Previously, we reported an association between autocrine stimulation of EGFR and constitutive signal transducers and activators of transcript...

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Veröffentlicht in:	Cell growth & differentiation 2002-08, Vol.13 (8), p.355-362
Hauptverfasser:	KIJIMA, Taro, NIWA, Hideo, STEINMAN, Richard A, DRENNING, Stephanie D, GOODING, William E, WENTZEL, Abbey L, SICHUAN XI, GRANDIS, Jennifer Rubin
Format:	Artikel
Sprache:	eng
Schlagworte:	Autocrine Communication - genetics bcl-X Protein Biological and medical sciences Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - physiopathology Cell Cycle - genetics Cell Division - genetics Cell physiology Cyclin D1 - genetics Cyclin D1 - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Epidermal Growth Factor - metabolism Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Neoplastic - genetics Head and Neck Neoplasms - metabolism Head and Neck Neoplasms - physiopathology Humans Molecular and cellular biology Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism Receptor, Epidermal Growth Factor - genetics Signal transduction STAT3 Transcription Factor Trans-Activators - genetics Trans-Activators - metabolism Tumor Cells, Cultured
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