Pulmonary diffusing capacity in chronic dialysis patients

Patients with end-stage renal disease treated by hemodialysis with bioincompatible membranes are exposed during the dialysis period to acute effects on lung microcirculation, which may result in pulmonary fibrosis and diffusion defects in long-standing dialysis. To investigate the occurrence of thes...

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Veröffentlicht in:Respiratory medicine 2002-07, Vol.96 (7), p.487-492
Hauptverfasser: HERRERO, J.A., ÁLVAREZ-SALA, J.L., CORONEL, F., MORATILLA, C., GÁMEZ, C., SÁNCHEZ-ALARCOS, J.M.F., BARRIENTOS, A.
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container_end_page 492
container_issue 7
container_start_page 487
container_title Respiratory medicine
container_volume 96
creator HERRERO, J.A.
ÁLVAREZ-SALA, J.L.
CORONEL, F.
MORATILLA, C.
GÁMEZ, C.
SÁNCHEZ-ALARCOS, J.M.F.
BARRIENTOS, A.
description Patients with end-stage renal disease treated by hemodialysis with bioincompatible membranes are exposed during the dialysis period to acute effects on lung microcirculation, which may result in pulmonary fibrosis and diffusion defects in long-standing dialysis. To investigate the occurrence of these possible chronic pulmonary alterations, we determined lung function in patients with chronic renal failure not undergoing hemodialysis and in patients who had been receiving regular hemodialysis both for short and long periods of time. Forty-three patients divided into three groups were studied: 17 patients before dialysis with a mean (SD) creatinine clearance of 14.1 (6.8) ml/minl 1.73 m2, 10 patients receiving regular hemodialysis for a period of less than 12 months (mean 6.4 ± 3.5 months), and 16 patients receiving regular hemodialysis for more than 5 years (mean 8.3 ± 3.6 years). First-use bioincompatible cellulosic dialysis membranes were used in all the cases. The following parameters were recorded: forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), total lung capacity (TLC), residual volume (RV), carbon monoxide transfer factor (TLCO), accesible lung volume (VA), carbon monoxide transfer factor/accesible lung volume (KCO— that is, TLCO/VA), and arterial blood gases. Patients receiving regular hemodialysis for more than 5 years showed significantly lower values of TLCO and KCO than patients before dialysis and patients receiving regular hemodialysis for less than 12 months. Seventy-five percent of patients on long-term hemodialysis had markedly reduced TLCO or KCO values (below 80% of the reference value) as compared with 17% of patients before dialysis and 10% of patients dialyzed for less than 12 months (P
doi_str_mv 10.1053/rmed.2002.1346
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To investigate the occurrence of these possible chronic pulmonary alterations, we determined lung function in patients with chronic renal failure not undergoing hemodialysis and in patients who had been receiving regular hemodialysis both for short and long periods of time. Forty-three patients divided into three groups were studied: 17 patients before dialysis with a mean (SD) creatinine clearance of 14.1 (6.8) ml/minl 1.73 m2, 10 patients receiving regular hemodialysis for a period of less than 12 months (mean 6.4 ± 3.5 months), and 16 patients receiving regular hemodialysis for more than 5 years (mean 8.3 ± 3.6 years). First-use bioincompatible cellulosic dialysis membranes were used in all the cases. The following parameters were recorded: forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), total lung capacity (TLC), residual volume (RV), carbon monoxide transfer factor (TLCO), accesible lung volume (VA), carbon monoxide transfer factor/accesible lung volume (KCO— that is, TLCO/VA), and arterial blood gases. Patients receiving regular hemodialysis for more than 5 years showed significantly lower values of TLCO and KCO than patients before dialysis and patients receiving regular hemodialysis for less than 12 months. Seventy-five percent of patients on long-term hemodialysis had markedly reduced TLCO or KCO values (below 80% of the reference value) as compared with 17% of patients before dialysis and 10% of patients dialyzed for less than 12 months (P&lt;0.001). Differences among groups for the remaining parameters were not observed. 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Dialysis management ; end-stage renal disease ; Female ; hemodialysis ; Humans ; Intensive care medicine ; Kidney Failure, Chronic - complications ; Kidney Failure, Chronic - therapy ; Male ; Medical sciences ; Middle Aged ; Plethysmography ; Pulmonary Diffusing Capacity ; pulmonary fibrosis ; Pulmonary Fibrosis - etiology ; Pulmonary Fibrosis - physiopathology ; Renal Dialysis - adverse effects ; Spirometry ; Statistics, Nonparametric ; Time Factors</subject><ispartof>Respiratory medicine, 2002-07, Vol.96 (7), p.487-492</ispartof><rights>2002 Elsevier Science Ltd</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c410t-d1091c32b417ecb8cfac336d91f51b15835410bb35e8b1dcae0f38c38ed3b97a3</citedby><cites>FETCH-LOGICAL-c410t-d1091c32b417ecb8cfac336d91f51b15835410bb35e8b1dcae0f38c38ed3b97a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0954611102913466$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=13805323$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12194631$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HERRERO, J.A.</creatorcontrib><creatorcontrib>ÁLVAREZ-SALA, J.L.</creatorcontrib><creatorcontrib>CORONEL, F.</creatorcontrib><creatorcontrib>MORATILLA, C.</creatorcontrib><creatorcontrib>GÁMEZ, C.</creatorcontrib><creatorcontrib>SÁNCHEZ-ALARCOS, J.M.F.</creatorcontrib><creatorcontrib>BARRIENTOS, A.</creatorcontrib><title>Pulmonary diffusing capacity in chronic dialysis patients</title><title>Respiratory medicine</title><addtitle>Respir Med</addtitle><description>Patients with end-stage renal disease treated by hemodialysis with bioincompatible membranes are exposed during the dialysis period to acute effects on lung microcirculation, which may result in pulmonary fibrosis and diffusion defects in long-standing dialysis. To investigate the occurrence of these possible chronic pulmonary alterations, we determined lung function in patients with chronic renal failure not undergoing hemodialysis and in patients who had been receiving regular hemodialysis both for short and long periods of time. Forty-three patients divided into three groups were studied: 17 patients before dialysis with a mean (SD) creatinine clearance of 14.1 (6.8) ml/minl 1.73 m2, 10 patients receiving regular hemodialysis for a period of less than 12 months (mean 6.4 ± 3.5 months), and 16 patients receiving regular hemodialysis for more than 5 years (mean 8.3 ± 3.6 years). First-use bioincompatible cellulosic dialysis membranes were used in all the cases. The following parameters were recorded: forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), total lung capacity (TLC), residual volume (RV), carbon monoxide transfer factor (TLCO), accesible lung volume (VA), carbon monoxide transfer factor/accesible lung volume (KCO— that is, TLCO/VA), and arterial blood gases. Patients receiving regular hemodialysis for more than 5 years showed significantly lower values of TLCO and KCO than patients before dialysis and patients receiving regular hemodialysis for less than 12 months. Seventy-five percent of patients on long-term hemodialysis had markedly reduced TLCO or KCO values (below 80% of the reference value) as compared with 17% of patients before dialysis and 10% of patients dialyzed for less than 12 months (P&lt;0.001). Differences among groups for the remaining parameters were not observed. 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Dialysis management</subject><subject>end-stage renal disease</subject><subject>Female</subject><subject>hemodialysis</subject><subject>Humans</subject><subject>Intensive care medicine</subject><subject>Kidney Failure, Chronic - complications</subject><subject>Kidney Failure, Chronic - therapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Plethysmography</subject><subject>Pulmonary Diffusing Capacity</subject><subject>pulmonary fibrosis</subject><subject>Pulmonary Fibrosis - etiology</subject><subject>Pulmonary Fibrosis - physiopathology</subject><subject>Renal Dialysis - adverse effects</subject><subject>Spirometry</subject><subject>Statistics, Nonparametric</subject><subject>Time Factors</subject><issn>0954-6111</issn><issn>1532-3064</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kLtOxDAQRS0EYpeFlhKlgS7BYzuJUyLES1oJCqgtZ-KAUV7YCdL-PY42gopqinvmauYQcg40AZrya9eaKmGUsgS4yA7IGlLOYk4zcUjWtEhFnAHAipx4_0kpLYSgx2QFDAqRcViT4mVq2r7TbhdVtq4nb7v3CPWg0Y67yHYRfri-sxhS3ey89dGgR2u60Z-So1o33pwtc0Pe7u9ebx_j7fPD0-3NNkYBdIwroAUgZ6WA3GApsdbIeVYVUKdQQip5Griy5KmRJVSoDa25RC5Nxcsi13xDrva9g-u_JuNH1VqPpml0Z_rJq5xRlkvJApjsQXS9987UanC2DZ8poGqWpWZZapalZllh4WJpnso5-cUXOwG4XADtUTe10x1a_8dxGVoZD5zccyZ4-LbGKY_BEZrKOoOjqnr73w0_aniFmw</recordid><startdate>20020701</startdate><enddate>20020701</enddate><creator>HERRERO, J.A.</creator><creator>ÁLVAREZ-SALA, J.L.</creator><creator>CORONEL, F.</creator><creator>MORATILLA, C.</creator><creator>GÁMEZ, C.</creator><creator>SÁNCHEZ-ALARCOS, J.M.F.</creator><creator>BARRIENTOS, A.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020701</creationdate><title>Pulmonary diffusing capacity in chronic dialysis patients</title><author>HERRERO, J.A. ; ÁLVAREZ-SALA, J.L. ; CORONEL, F. ; MORATILLA, C. ; GÁMEZ, C. ; SÁNCHEZ-ALARCOS, J.M.F. ; BARRIENTOS, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c410t-d1091c32b417ecb8cfac336d91f51b15835410bb35e8b1dcae0f38c38ed3b97a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Aged</topic><topic>Analysis of Variance</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>bioincompatible membranes</topic><topic>Biological and medical sciences</topic><topic>Cross-Sectional Studies</topic><topic>Emergency and intensive care: renal failure. Dialysis management</topic><topic>end-stage renal disease</topic><topic>Female</topic><topic>hemodialysis</topic><topic>Humans</topic><topic>Intensive care medicine</topic><topic>Kidney Failure, Chronic - complications</topic><topic>Kidney Failure, Chronic - therapy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Plethysmography</topic><topic>Pulmonary Diffusing Capacity</topic><topic>pulmonary fibrosis</topic><topic>Pulmonary Fibrosis - etiology</topic><topic>Pulmonary Fibrosis - physiopathology</topic><topic>Renal Dialysis - adverse effects</topic><topic>Spirometry</topic><topic>Statistics, Nonparametric</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HERRERO, J.A.</creatorcontrib><creatorcontrib>ÁLVAREZ-SALA, J.L.</creatorcontrib><creatorcontrib>CORONEL, F.</creatorcontrib><creatorcontrib>MORATILLA, C.</creatorcontrib><creatorcontrib>GÁMEZ, C.</creatorcontrib><creatorcontrib>SÁNCHEZ-ALARCOS, J.M.F.</creatorcontrib><creatorcontrib>BARRIENTOS, A.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Respiratory medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HERRERO, J.A.</au><au>ÁLVAREZ-SALA, J.L.</au><au>CORONEL, F.</au><au>MORATILLA, C.</au><au>GÁMEZ, C.</au><au>SÁNCHEZ-ALARCOS, J.M.F.</au><au>BARRIENTOS, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pulmonary diffusing capacity in chronic dialysis patients</atitle><jtitle>Respiratory medicine</jtitle><addtitle>Respir Med</addtitle><date>2002-07-01</date><risdate>2002</risdate><volume>96</volume><issue>7</issue><spage>487</spage><epage>492</epage><pages>487-492</pages><issn>0954-6111</issn><eissn>1532-3064</eissn><abstract>Patients with end-stage renal disease treated by hemodialysis with bioincompatible membranes are exposed during the dialysis period to acute effects on lung microcirculation, which may result in pulmonary fibrosis and diffusion defects in long-standing dialysis. To investigate the occurrence of these possible chronic pulmonary alterations, we determined lung function in patients with chronic renal failure not undergoing hemodialysis and in patients who had been receiving regular hemodialysis both for short and long periods of time. Forty-three patients divided into three groups were studied: 17 patients before dialysis with a mean (SD) creatinine clearance of 14.1 (6.8) ml/minl 1.73 m2, 10 patients receiving regular hemodialysis for a period of less than 12 months (mean 6.4 ± 3.5 months), and 16 patients receiving regular hemodialysis for more than 5 years (mean 8.3 ± 3.6 years). First-use bioincompatible cellulosic dialysis membranes were used in all the cases. The following parameters were recorded: forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), total lung capacity (TLC), residual volume (RV), carbon monoxide transfer factor (TLCO), accesible lung volume (VA), carbon monoxide transfer factor/accesible lung volume (KCO— that is, TLCO/VA), and arterial blood gases. Patients receiving regular hemodialysis for more than 5 years showed significantly lower values of TLCO and KCO than patients before dialysis and patients receiving regular hemodialysis for less than 12 months. Seventy-five percent of patients on long-term hemodialysis had markedly reduced TLCO or KCO values (below 80% of the reference value) as compared with 17% of patients before dialysis and 10% of patients dialyzed for less than 12 months (P&lt;0.001). Differences among groups for the remaining parameters were not observed. In conclusion, patients undergoing long-term regular hemodialysis with a bioincompatible membrane showed a selective reduction in pulmonary diffusing capacity possibly due to chronic pulmonary fibrosis.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>12194631</pmid><doi>10.1053/rmed.2002.1346</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record>
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source MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
subjects Aged
Analysis of Variance
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
bioincompatible membranes
Biological and medical sciences
Cross-Sectional Studies
Emergency and intensive care: renal failure. Dialysis management
end-stage renal disease
Female
hemodialysis
Humans
Intensive care medicine
Kidney Failure, Chronic - complications
Kidney Failure, Chronic - therapy
Male
Medical sciences
Middle Aged
Plethysmography
Pulmonary Diffusing Capacity
pulmonary fibrosis
Pulmonary Fibrosis - etiology
Pulmonary Fibrosis - physiopathology
Renal Dialysis - adverse effects
Spirometry
Statistics, Nonparametric
Time Factors
title Pulmonary diffusing capacity in chronic dialysis patients
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