Prognostic value of serum beta 2 microglobulin in primary gastric lymphoma
Sixty‐eight previously untreated patients with primary gastric non‐Hodgkin's lymphoma (NHL) available for analysis, were entered in a study in which the prognostic significance of serum beta 2 microglobulin levels were evaluated. The serum beta 2 microglobulin was the most significant prognosti...
Gespeichert in:
| Veröffentlicht in: | Hematological oncology 1991-10, Vol.9 (2), p.115-121 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 121 |
|---|---|
| container_issue | 2 |
| container_start_page | 115 |
| container_title | Hematological oncology |
| container_volume | 9 |
| creator | Avilés, Agustin Díaz-Maqueo, José C. Rodriguez, Leticia García, Edna L. Guzmán, Renaldo Talavera, Alejandra |
| description | Sixty‐eight previously untreated patients with primary gastric non‐Hodgkin's lymphoma (NHL) available for analysis, were entered in a study in which the prognostic significance of serum beta 2 microglobulin levels were evaluated.
The serum beta 2 microglobulin was the most significant prognostic factor. Patients with high levels (> 3.5 μg/mL) had a relapse‐free survival (RFS) of 36 months, while the median RFS has not been reached in patients with normal levels (p 0.001).
Serum beta 2 microglobulin should be included in the initial staging of patients with primary extranodal NHL and patients with high levels should be treated more aggressively. |
| doi_str_mv | 10.1002/hon.2900090207 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72027701</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>72027701</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4077-14a94c89273f3abd056deba5a4e35f0195873d81ffe6fff1c06457bf6e0ad9523</originalsourceid><addsrcrecordid>eNqFkM1LxDAQxYMo6_px9Sb0IN66TtK0aY4quqssrgdF8BLSNtFq2qxJq-5_b6SL4kkYmMP83sybh9ABhgkGICfPtp0QDgAcCLANNMbAeYwh45toDITlMZCEbKMd71--KQ75CI1wnnFCyRhd3zr71Frf1WX0Lk2vIqsjr1zfRIXqZESipi4DYmzRm7qNQi1d3Ui3ip6k71yQmVWzfLaN3ENbWhqv9td9F91fXtydz-L5Ynp1fjqPSwqMxZhKTsucE5boRBYVpFmlCplKqpJUA-ZpzpIqx1qrTGuNS8hoygqdKZAVT0myi46HvUtn33rlO9HUvlTGyFbZ3gtGwtsMcAAnAxge8N4pLdbWBQbxHZ4I4Ynf8ILgcL25LxpV_eJDWmF-tJ5LX0qjnWzL2v9glKeUch4wPmAftVGrf46K2eLmj4V40Na-U58_WuleRcYSloqHm6ng-HEOZ3km8uQLtt-W3A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72027701</pqid></control><display><type>article</type><title>Prognostic value of serum beta 2 microglobulin in primary gastric lymphoma</title><source>MEDLINE</source><source>Wiley Journals</source><creator>Avilés, Agustin ; Díaz-Maqueo, José C. ; Rodriguez, Leticia ; García, Edna L. ; Guzmán, Renaldo ; Talavera, Alejandra</creator><creatorcontrib>Avilés, Agustin ; Díaz-Maqueo, José C. ; Rodriguez, Leticia ; García, Edna L. ; Guzmán, Renaldo ; Talavera, Alejandra</creatorcontrib><description>Sixty‐eight previously untreated patients with primary gastric non‐Hodgkin's lymphoma (NHL) available for analysis, were entered in a study in which the prognostic significance of serum beta 2 microglobulin levels were evaluated.
The serum beta 2 microglobulin was the most significant prognostic factor. Patients with high levels (> 3.5 μg/mL) had a relapse‐free survival (RFS) of 36 months, while the median RFS has not been reached in patients with normal levels (p<0.001). The 5‐year survival was 80 per cent for patients with normal levels, statistically significant when compared to patients with high levels: 38 per cent (p> 0.001).
Serum beta 2 microglobulin should be included in the initial staging of patients with primary extranodal NHL and patients with high levels should be treated more aggressively.</description><identifier>ISSN: 0278-0232</identifier><identifier>EISSN: 1099-1069</identifier><identifier>DOI: 10.1002/hon.2900090207</identifier><identifier>PMID: 1869242</identifier><identifier>CODEN: HAONDL</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Age Factors ; B2 microglobulin ; beta 2-Microglobulin - analysis ; Biological and medical sciences ; Female ; Gastric lymphoma ; Hematologic and hematopoietic diseases ; Humans ; L-Lactate Dehydrogenase - blood ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lymphoma, Non-Hodgkin - blood ; Lymphoma, Non-Hodgkin - diagnosis ; Lymphoma, Non-Hodgkin - pathology ; Male ; Medical sciences ; Prognosis ; Sex Factors ; Stomach Neoplasms - blood ; Stomach Neoplasms - diagnosis ; Survival Analysis</subject><ispartof>Hematological oncology, 1991-10, Vol.9 (2), p.115-121</ispartof><rights>Copyright © 1991 John Wiley & Sons, Ltd</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4077-14a94c89273f3abd056deba5a4e35f0195873d81ffe6fff1c06457bf6e0ad9523</citedby><cites>FETCH-LOGICAL-c4077-14a94c89273f3abd056deba5a4e35f0195873d81ffe6fff1c06457bf6e0ad9523</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhon.2900090207$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhon.2900090207$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4954499$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1869242$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Avilés, Agustin</creatorcontrib><creatorcontrib>Díaz-Maqueo, José C.</creatorcontrib><creatorcontrib>Rodriguez, Leticia</creatorcontrib><creatorcontrib>García, Edna L.</creatorcontrib><creatorcontrib>Guzmán, Renaldo</creatorcontrib><creatorcontrib>Talavera, Alejandra</creatorcontrib><title>Prognostic value of serum beta 2 microglobulin in primary gastric lymphoma</title><title>Hematological oncology</title><addtitle>Hematol. Oncol</addtitle><description>Sixty‐eight previously untreated patients with primary gastric non‐Hodgkin's lymphoma (NHL) available for analysis, were entered in a study in which the prognostic significance of serum beta 2 microglobulin levels were evaluated.
The serum beta 2 microglobulin was the most significant prognostic factor. Patients with high levels (> 3.5 μg/mL) had a relapse‐free survival (RFS) of 36 months, while the median RFS has not been reached in patients with normal levels (p<0.001). The 5‐year survival was 80 per cent for patients with normal levels, statistically significant when compared to patients with high levels: 38 per cent (p> 0.001).
Serum beta 2 microglobulin should be included in the initial staging of patients with primary extranodal NHL and patients with high levels should be treated more aggressively.</description><subject>Age Factors</subject><subject>B2 microglobulin</subject><subject>beta 2-Microglobulin - analysis</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Gastric lymphoma</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>L-Lactate Dehydrogenase - blood</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Lymphoma, Non-Hodgkin - blood</subject><subject>Lymphoma, Non-Hodgkin - diagnosis</subject><subject>Lymphoma, Non-Hodgkin - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Prognosis</subject><subject>Sex Factors</subject><subject>Stomach Neoplasms - blood</subject><subject>Stomach Neoplasms - diagnosis</subject><subject>Survival Analysis</subject><issn>0278-0232</issn><issn>1099-1069</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1LxDAQxYMo6_px9Sb0IN66TtK0aY4quqssrgdF8BLSNtFq2qxJq-5_b6SL4kkYmMP83sybh9ABhgkGICfPtp0QDgAcCLANNMbAeYwh45toDITlMZCEbKMd71--KQ75CI1wnnFCyRhd3zr71Frf1WX0Lk2vIqsjr1zfRIXqZESipi4DYmzRm7qNQi1d3Ui3ip6k71yQmVWzfLaN3ENbWhqv9td9F91fXtydz-L5Ynp1fjqPSwqMxZhKTsucE5boRBYVpFmlCplKqpJUA-ZpzpIqx1qrTGuNS8hoygqdKZAVT0myi46HvUtn33rlO9HUvlTGyFbZ3gtGwtsMcAAnAxge8N4pLdbWBQbxHZ4I4Ynf8ILgcL25LxpV_eJDWmF-tJ5LX0qjnWzL2v9glKeUch4wPmAftVGrf46K2eLmj4V40Na-U58_WuleRcYSloqHm6ng-HEOZ3km8uQLtt-W3A</recordid><startdate>199110</startdate><enddate>199110</enddate><creator>Avilés, Agustin</creator><creator>Díaz-Maqueo, José C.</creator><creator>Rodriguez, Leticia</creator><creator>García, Edna L.</creator><creator>Guzmán, Renaldo</creator><creator>Talavera, Alejandra</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199110</creationdate><title>Prognostic value of serum beta 2 microglobulin in primary gastric lymphoma</title><author>Avilés, Agustin ; Díaz-Maqueo, José C. ; Rodriguez, Leticia ; García, Edna L. ; Guzmán, Renaldo ; Talavera, Alejandra</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4077-14a94c89273f3abd056deba5a4e35f0195873d81ffe6fff1c06457bf6e0ad9523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Age Factors</topic><topic>B2 microglobulin</topic><topic>beta 2-Microglobulin - analysis</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Gastric lymphoma</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>L-Lactate Dehydrogenase - blood</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Lymphoma, Non-Hodgkin - blood</topic><topic>Lymphoma, Non-Hodgkin - diagnosis</topic><topic>Lymphoma, Non-Hodgkin - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Prognosis</topic><topic>Sex Factors</topic><topic>Stomach Neoplasms - blood</topic><topic>Stomach Neoplasms - diagnosis</topic><topic>Survival Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Avilés, Agustin</creatorcontrib><creatorcontrib>Díaz-Maqueo, José C.</creatorcontrib><creatorcontrib>Rodriguez, Leticia</creatorcontrib><creatorcontrib>García, Edna L.</creatorcontrib><creatorcontrib>Guzmán, Renaldo</creatorcontrib><creatorcontrib>Talavera, Alejandra</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hematological oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Avilés, Agustin</au><au>Díaz-Maqueo, José C.</au><au>Rodriguez, Leticia</au><au>García, Edna L.</au><au>Guzmán, Renaldo</au><au>Talavera, Alejandra</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic value of serum beta 2 microglobulin in primary gastric lymphoma</atitle><jtitle>Hematological oncology</jtitle><addtitle>Hematol. Oncol</addtitle><date>1991-10</date><risdate>1991</risdate><volume>9</volume><issue>2</issue><spage>115</spage><epage>121</epage><pages>115-121</pages><issn>0278-0232</issn><eissn>1099-1069</eissn><coden>HAONDL</coden><abstract>Sixty‐eight previously untreated patients with primary gastric non‐Hodgkin's lymphoma (NHL) available for analysis, were entered in a study in which the prognostic significance of serum beta 2 microglobulin levels were evaluated.
The serum beta 2 microglobulin was the most significant prognostic factor. Patients with high levels (> 3.5 μg/mL) had a relapse‐free survival (RFS) of 36 months, while the median RFS has not been reached in patients with normal levels (p<0.001). The 5‐year survival was 80 per cent for patients with normal levels, statistically significant when compared to patients with high levels: 38 per cent (p> 0.001).
Serum beta 2 microglobulin should be included in the initial staging of patients with primary extranodal NHL and patients with high levels should be treated more aggressively.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>1869242</pmid><doi>10.1002/hon.2900090207</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0278-0232 |
| ispartof | Hematological oncology, 1991-10, Vol.9 (2), p.115-121 |
| issn | 0278-0232 1099-1069 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72027701 |
| source | MEDLINE; Wiley Journals |
| subjects | Age Factors B2 microglobulin beta 2-Microglobulin - analysis Biological and medical sciences Female Gastric lymphoma Hematologic and hematopoietic diseases Humans L-Lactate Dehydrogenase - blood Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma, Non-Hodgkin - blood Lymphoma, Non-Hodgkin - diagnosis Lymphoma, Non-Hodgkin - pathology Male Medical sciences Prognosis Sex Factors Stomach Neoplasms - blood Stomach Neoplasms - diagnosis Survival Analysis |
| title | Prognostic value of serum beta 2 microglobulin in primary gastric lymphoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T04%3A04%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prognostic%20value%20of%20serum%20beta%202%20microglobulin%20in%20primary%20gastric%20lymphoma&rft.jtitle=Hematological%20oncology&rft.au=Avil%C3%A9s,%20Agustin&rft.date=1991-10&rft.volume=9&rft.issue=2&rft.spage=115&rft.epage=121&rft.pages=115-121&rft.issn=0278-0232&rft.eissn=1099-1069&rft.coden=HAONDL&rft_id=info:doi/10.1002/hon.2900090207&rft_dat=%3Cproquest_cross%3E72027701%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=72027701&rft_id=info:pmid/1869242&rfr_iscdi=true |