Primary Amphipathic Cell-Penetrating Peptides:  Structural Requirements and Interactions with Model Membranes

To identify rules for the design of efficient cell-penetrating peptides that deliver therapeutic agents into subcellular compartments, we compared the properties of two closely related primary amphipathic peptides that mainly differ by their conformational state. On the basis of a peptide Pβ that is...

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Veröffentlicht in:	Biochemistry (Easton) 2004-06, Vol.43 (24), p.7698-7706
Hauptverfasser:	Deshayes, Sébastien, Plénat, Thomas, Aldrian-Herrada, Gudrun, Divita, Gilles, Le Grimellec, Christian, Heitz, Frédéric
Format:	Artikel
Sprache:	eng
Schlagworte:	Adsorption Amino Acid Sequence Circular Dichroism Membranes, Artificial Microscopy, Atomic Force Molecular Sequence Data Peptides - chemistry Spectroscopy, Fourier Transform Infrared
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