The relation between Helicobacter pylori and atherosclerosis cannot be explained by a high homocysteine concentration
Background Recent studies have suggested that a chronic infection with Helicobacter pylori might be an independent risk factor for atherosclerosis. However, a direct role in atherogenesis is not plausible, since the bacterium has not been isolated from atherosclerotic lesions. An indirect mechanism...
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| Veröffentlicht in: | European journal of clinical investigation 2002-08, Vol.32 (8), p.549-555 |
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| creator | Bloemenkamp, D. G. M. Mali, W. P. Th. M. Tanis, B. C. Rosendaal, F. R. Van Den Bosch, M. A. A. J. Kemmeren, J. M. Algra, A. Visseren, F. L. J. Van Der Graaf, Y. |
| description | Background Recent studies have suggested that a chronic infection with Helicobacter pylori might be an independent risk factor for atherosclerosis. However, a direct role in atherogenesis is not plausible, since the bacterium has not been isolated from atherosclerotic lesions. An indirect mechanism that could link H. pylori with atherosclerosis might be through an increase in plasma homocysteine concentration caused by deficiencies of vitamin B12 and folate in plasma.
Materials and methods In 150 female patients with peripheral arterial disease (PAD) and in 412 healthy control women from a nation‐wide population‐based case–control study, blood samples were collected to determine the antibody titre against H. pylori and to measure plasma homocysteine, folate and vitamin B12 levels. First, the odds ratio for PAD in women with a positive antibody titre against H. pylori was calculated and adjusted for homocysteine level. Secondly, mean concentrations of vitamin B12, folate and homocysteine were compared in healthy controls with a positive or negative antibody titre against H. pylori. Thirdly, the relation between H. pylori and PAD in individuals with a normal or high homocysteine level was investigated.
Results A positive immunoglobulin G antibody titre against H. pylori was found in 42% of the PAD patients and in 27% of the controls. The age‐ and socio‐economic‐status (SES) adjusted odds ratio for PAD was 1·5 (95%CI; 1·0–2·2). Additional adjustment for homocysteine plasma concentration did not essentially change the odds ratio. Secondly, among the healthy controls, the homocysteine plasma concentration did not depend on the immunoglobulin G titre, neither did the folate plasma concentration. The concentration of vitamin B12 was slightly higher in women with a positive titre. Thirdly, H. pylori infection was a risk factor for PAD in subjects with a normal homocysteine concentration [OR 2·0 (95%CI 1·3–3·1)].
Conclusions This study shows a relationship between a positive immunoglobulin G antibody titre against H. pylori and PAD in young women. Moreover, this study does not support the hypothesis that H. pylori infection is related to atherosclerosis via an increase in plasma homocysteine concentration. |
| doi_str_mv | 10.1046/j.1365-2362.2002.01022.x |
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Materials and methods In 150 female patients with peripheral arterial disease (PAD) and in 412 healthy control women from a nation‐wide population‐based case–control study, blood samples were collected to determine the antibody titre against H. pylori and to measure plasma homocysteine, folate and vitamin B12 levels. First, the odds ratio for PAD in women with a positive antibody titre against H. pylori was calculated and adjusted for homocysteine level. Secondly, mean concentrations of vitamin B12, folate and homocysteine were compared in healthy controls with a positive or negative antibody titre against H. pylori. Thirdly, the relation between H. pylori and PAD in individuals with a normal or high homocysteine level was investigated.
Results A positive immunoglobulin G antibody titre against H. pylori was found in 42% of the PAD patients and in 27% of the controls. The age‐ and socio‐economic‐status (SES) adjusted odds ratio for PAD was 1·5 (95%CI; 1·0–2·2). Additional adjustment for homocysteine plasma concentration did not essentially change the odds ratio. Secondly, among the healthy controls, the homocysteine plasma concentration did not depend on the immunoglobulin G titre, neither did the folate plasma concentration. The concentration of vitamin B12 was slightly higher in women with a positive titre. Thirdly, H. pylori infection was a risk factor for PAD in subjects with a normal homocysteine concentration [OR 2·0 (95%CI 1·3–3·1)].
Conclusions This study shows a relationship between a positive immunoglobulin G antibody titre against H. pylori and PAD in young women. Moreover, this study does not support the hypothesis that H. pylori infection is related to atherosclerosis via an increase in plasma homocysteine concentration.</description><identifier>ISSN: 0014-2972</identifier><identifier>EISSN: 1365-2362</identifier><identifier>DOI: 10.1046/j.1365-2362.2002.01022.x</identifier><identifier>PMID: 12190953</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Adolescent ; Adult ; Age Factors ; Antigens, Bacterial - blood ; Arteriosclerosis - blood ; Arteriosclerosis - immunology ; Arteriosclerosis - microbiology ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Case-Control Studies ; Chronic Disease ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; Female ; Folic Acid Deficiency - blood ; Helicobacter Infections - blood ; Helicobacter Infections - complications ; Helicobacter Infections - immunology ; Helicobacter pylori ; Helicobacter pylori - immunology ; homocysteine ; Homocysteine - blood ; Humans ; Immunoglobulin G - blood ; Medical sciences ; Middle Aged ; Odds Ratio ; peripheral arterial disease ; Peripheral Vascular Diseases - blood ; Peripheral Vascular Diseases - immunology ; Peripheral Vascular Diseases - microbiology ; Risk Factors ; Socioeconomic Factors ; Vitamin B 12 Deficiency - blood</subject><ispartof>European journal of clinical investigation, 2002-08, Vol.32 (8), p.549-555</ispartof><rights>2002 INIST-CNRS</rights><rights>Copyright Blackwell Scientific Publications Ltd. Aug 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4602-e5dc35aa14b6ebdd85cc5df6ee35312129380a96524ee68602003c963ab3dd843</citedby><cites>FETCH-LOGICAL-c4602-e5dc35aa14b6ebdd85cc5df6ee35312129380a96524ee68602003c963ab3dd843</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1365-2362.2002.01022.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1365-2362.2002.01022.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13880456$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12190953$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bloemenkamp, D. G. M.</creatorcontrib><creatorcontrib>Mali, W. P. Th. M.</creatorcontrib><creatorcontrib>Tanis, B. C.</creatorcontrib><creatorcontrib>Rosendaal, F. R.</creatorcontrib><creatorcontrib>Van Den Bosch, M. A. A. J.</creatorcontrib><creatorcontrib>Kemmeren, J. M.</creatorcontrib><creatorcontrib>Algra, A.</creatorcontrib><creatorcontrib>Visseren, F. L. J.</creatorcontrib><creatorcontrib>Van Der Graaf, Y.</creatorcontrib><title>The relation between Helicobacter pylori and atherosclerosis cannot be explained by a high homocysteine concentration</title><title>European journal of clinical investigation</title><addtitle>Eur J Clin Invest</addtitle><description>Background Recent studies have suggested that a chronic infection with Helicobacter pylori might be an independent risk factor for atherosclerosis. However, a direct role in atherogenesis is not plausible, since the bacterium has not been isolated from atherosclerotic lesions. An indirect mechanism that could link H. pylori with atherosclerosis might be through an increase in plasma homocysteine concentration caused by deficiencies of vitamin B12 and folate in plasma.
Materials and methods In 150 female patients with peripheral arterial disease (PAD) and in 412 healthy control women from a nation‐wide population‐based case–control study, blood samples were collected to determine the antibody titre against H. pylori and to measure plasma homocysteine, folate and vitamin B12 levels. First, the odds ratio for PAD in women with a positive antibody titre against H. pylori was calculated and adjusted for homocysteine level. Secondly, mean concentrations of vitamin B12, folate and homocysteine were compared in healthy controls with a positive or negative antibody titre against H. pylori. Thirdly, the relation between H. pylori and PAD in individuals with a normal or high homocysteine level was investigated.
Results A positive immunoglobulin G antibody titre against H. pylori was found in 42% of the PAD patients and in 27% of the controls. The age‐ and socio‐economic‐status (SES) adjusted odds ratio for PAD was 1·5 (95%CI; 1·0–2·2). Additional adjustment for homocysteine plasma concentration did not essentially change the odds ratio. Secondly, among the healthy controls, the homocysteine plasma concentration did not depend on the immunoglobulin G titre, neither did the folate plasma concentration. The concentration of vitamin B12 was slightly higher in women with a positive titre. Thirdly, H. pylori infection was a risk factor for PAD in subjects with a normal homocysteine concentration [OR 2·0 (95%CI 1·3–3·1)].
Conclusions This study shows a relationship between a positive immunoglobulin G antibody titre against H. pylori and PAD in young women. Moreover, this study does not support the hypothesis that H. pylori infection is related to atherosclerosis via an increase in plasma homocysteine concentration.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Antigens, Bacterial - blood</subject><subject>Arteriosclerosis - blood</subject><subject>Arteriosclerosis - immunology</subject><subject>Arteriosclerosis - microbiology</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Case-Control Studies</subject><subject>Chronic Disease</subject><subject>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</subject><subject>Female</subject><subject>Folic Acid Deficiency - blood</subject><subject>Helicobacter Infections - blood</subject><subject>Helicobacter Infections - complications</subject><subject>Helicobacter Infections - immunology</subject><subject>Helicobacter pylori</subject><subject>Helicobacter pylori - immunology</subject><subject>homocysteine</subject><subject>Homocysteine - blood</subject><subject>Humans</subject><subject>Immunoglobulin G - blood</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Odds Ratio</subject><subject>peripheral arterial disease</subject><subject>Peripheral Vascular Diseases - blood</subject><subject>Peripheral Vascular Diseases - immunology</subject><subject>Peripheral Vascular Diseases - microbiology</subject><subject>Risk Factors</subject><subject>Socioeconomic Factors</subject><subject>Vitamin B 12 Deficiency - blood</subject><issn>0014-2972</issn><issn>1365-2362</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1u1DAUhS0EotPCKyALie4S_BN7kgULNCptpQqKVNSl5Th3iAePPdiJOnl7nM6olbpiY1v2d47vvQchTElJSSU_b0rKpSgYl6xkhLCSUMJYuX-FFk8Pr9GCEFoVrFmyE3Sa0oYQUlPO3qITymhDGsEXaLzrAUdwerDB4xaGBwCPr8BZE1ptBoh4N7kQLda-w3roIYZk3LzahI32PgxZhmG_c9p66HA7YY17-7vHfdgGM6UB8j02wRvwQ3z86B16s9YuwfvjfoZ-fbu4W10VNz8ur1dfbwpTScIKEJ3hQmtatRLarquFMaJbSwAueO6BNbwmupGCVQCyzhJCuGkk1y3PdMXP0PnBdxfD3xHSoLY2GXBOewhjUktG2JKxOoMfX4CbMEafa1O0aSgVjM9u9QEyufsUYa120W51nBQlas5FbdQ8fjWPX825qMdc1D5LPxz9x3YL3bPwGEQGPh0BnYx266i9semZ43VNKiEz9-XAPVgH038XoC5W1_Mp64uD3uZc9k96Hf8oueRLoe6_X6qK1bf3q1uhfvJ_xG24tA</recordid><startdate>200208</startdate><enddate>200208</enddate><creator>Bloemenkamp, D. G. M.</creator><creator>Mali, W. P. Th. M.</creator><creator>Tanis, B. C.</creator><creator>Rosendaal, F. R.</creator><creator>Van Den Bosch, M. A. A. J.</creator><creator>Kemmeren, J. M.</creator><creator>Algra, A.</creator><creator>Visseren, F. L. J.</creator><creator>Van Der Graaf, Y.</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>200208</creationdate><title>The relation between Helicobacter pylori and atherosclerosis cannot be explained by a high homocysteine concentration</title><author>Bloemenkamp, D. G. M. ; Mali, W. P. Th. M. ; Tanis, B. C. ; Rosendaal, F. R. ; Van Den Bosch, M. A. A. J. ; Kemmeren, J. M. ; Algra, A. ; Visseren, F. L. J. ; Van Der Graaf, Y.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4602-e5dc35aa14b6ebdd85cc5df6ee35312129380a96524ee68602003c963ab3dd843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Antigens, Bacterial - blood</topic><topic>Arteriosclerosis - blood</topic><topic>Arteriosclerosis - immunology</topic><topic>Arteriosclerosis - microbiology</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Case-Control Studies</topic><topic>Chronic Disease</topic><topic>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</topic><topic>Female</topic><topic>Folic Acid Deficiency - blood</topic><topic>Helicobacter Infections - blood</topic><topic>Helicobacter Infections - complications</topic><topic>Helicobacter Infections - immunology</topic><topic>Helicobacter pylori</topic><topic>Helicobacter pylori - immunology</topic><topic>homocysteine</topic><topic>Homocysteine - blood</topic><topic>Humans</topic><topic>Immunoglobulin G - blood</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Odds Ratio</topic><topic>peripheral arterial disease</topic><topic>Peripheral Vascular Diseases - blood</topic><topic>Peripheral Vascular Diseases - immunology</topic><topic>Peripheral Vascular Diseases - microbiology</topic><topic>Risk Factors</topic><topic>Socioeconomic Factors</topic><topic>Vitamin B 12 Deficiency - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bloemenkamp, D. G. M.</creatorcontrib><creatorcontrib>Mali, W. P. Th. M.</creatorcontrib><creatorcontrib>Tanis, B. C.</creatorcontrib><creatorcontrib>Rosendaal, F. R.</creatorcontrib><creatorcontrib>Van Den Bosch, M. A. A. J.</creatorcontrib><creatorcontrib>Kemmeren, J. M.</creatorcontrib><creatorcontrib>Algra, A.</creatorcontrib><creatorcontrib>Visseren, F. L. J.</creatorcontrib><creatorcontrib>Van Der Graaf, Y.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bloemenkamp, D. G. M.</au><au>Mali, W. P. Th. M.</au><au>Tanis, B. C.</au><au>Rosendaal, F. R.</au><au>Van Den Bosch, M. A. A. J.</au><au>Kemmeren, J. M.</au><au>Algra, A.</au><au>Visseren, F. L. J.</au><au>Van Der Graaf, Y.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The relation between Helicobacter pylori and atherosclerosis cannot be explained by a high homocysteine concentration</atitle><jtitle>European journal of clinical investigation</jtitle><addtitle>Eur J Clin Invest</addtitle><date>2002-08</date><risdate>2002</risdate><volume>32</volume><issue>8</issue><spage>549</spage><epage>555</epage><pages>549-555</pages><issn>0014-2972</issn><eissn>1365-2362</eissn><abstract>Background Recent studies have suggested that a chronic infection with Helicobacter pylori might be an independent risk factor for atherosclerosis. However, a direct role in atherogenesis is not plausible, since the bacterium has not been isolated from atherosclerotic lesions. An indirect mechanism that could link H. pylori with atherosclerosis might be through an increase in plasma homocysteine concentration caused by deficiencies of vitamin B12 and folate in plasma.
Materials and methods In 150 female patients with peripheral arterial disease (PAD) and in 412 healthy control women from a nation‐wide population‐based case–control study, blood samples were collected to determine the antibody titre against H. pylori and to measure plasma homocysteine, folate and vitamin B12 levels. First, the odds ratio for PAD in women with a positive antibody titre against H. pylori was calculated and adjusted for homocysteine level. Secondly, mean concentrations of vitamin B12, folate and homocysteine were compared in healthy controls with a positive or negative antibody titre against H. pylori. Thirdly, the relation between H. pylori and PAD in individuals with a normal or high homocysteine level was investigated.
Results A positive immunoglobulin G antibody titre against H. pylori was found in 42% of the PAD patients and in 27% of the controls. The age‐ and socio‐economic‐status (SES) adjusted odds ratio for PAD was 1·5 (95%CI; 1·0–2·2). Additional adjustment for homocysteine plasma concentration did not essentially change the odds ratio. Secondly, among the healthy controls, the homocysteine plasma concentration did not depend on the immunoglobulin G titre, neither did the folate plasma concentration. The concentration of vitamin B12 was slightly higher in women with a positive titre. Thirdly, H. pylori infection was a risk factor for PAD in subjects with a normal homocysteine concentration [OR 2·0 (95%CI 1·3–3·1)].
Conclusions This study shows a relationship between a positive immunoglobulin G antibody titre against H. pylori and PAD in young women. Moreover, this study does not support the hypothesis that H. pylori infection is related to atherosclerosis via an increase in plasma homocysteine concentration.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>12190953</pmid><doi>10.1046/j.1365-2362.2002.01022.x</doi><tpages>7</tpages></addata></record> |
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| subjects | Adolescent Adult Age Factors Antigens, Bacterial - blood Arteriosclerosis - blood Arteriosclerosis - immunology Arteriosclerosis - microbiology Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Case-Control Studies Chronic Disease Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Female Folic Acid Deficiency - blood Helicobacter Infections - blood Helicobacter Infections - complications Helicobacter Infections - immunology Helicobacter pylori Helicobacter pylori - immunology homocysteine Homocysteine - blood Humans Immunoglobulin G - blood Medical sciences Middle Aged Odds Ratio peripheral arterial disease Peripheral Vascular Diseases - blood Peripheral Vascular Diseases - immunology Peripheral Vascular Diseases - microbiology Risk Factors Socioeconomic Factors Vitamin B 12 Deficiency - blood |
| title | The relation between Helicobacter pylori and atherosclerosis cannot be explained by a high homocysteine concentration |
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