Regulatory Roles for APJ, a Seven-transmembrane Receptor Related to Angiotensin-type 1 Receptor in Blood Pressure in Vivo

APJ is a G-protein-coupled receptor with seven transmembrane domains, and its endogenous ligand, apelin, was identified recently. They are highly expressed in the cardiovascular system, suggesting that APJ is important in the regulation of blood pressure. To investigate the physiological functions o...

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Veröffentlicht in:	The Journal of biological chemistry 2004-06, Vol.279 (25), p.26274-26279
Hauptverfasser:	Ishida, Junji, Hashimoto, Tatsuo, Hashimoto, Yasumi, Nishiwaki, Shiro, Iguchi, Taku, Harada, Shuichi, Sugaya, Takeshi, Matsuzaki, Hitomi, Yamamoto, Rie, Shiota, Naotaka, Okunishi, Hideki, Kihara, Minoru, Umemura, Satoshi, Sugiyama, Fumihiro, Yagami, Ken-ichi, Kasuya, Yoshitoshi, Mochizuki, Naoki, Fukamizu, Akiyoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Angiotensin II - metabolism Animals Apelin Receptors Blood Pressure Blotting, Northern DNA, Complementary - metabolism Endothelium - enzymology Endothelium, Vascular - metabolism Enzyme Inhibitors - pharmacology Homozygote Humans Male Mice Mice, Inbred C57BL Mice, Mutant Strains Models, Genetic NG-Nitroarginine Methyl Ester - metabolism Nitric Oxide Synthase - antagonists & inhibitors Phosphorylation Protein Structure, Tertiary Rats Rats, Inbred WKY Receptor, Angiotensin, Type 1 - chemistry Receptor, Angiotensin, Type 1 - metabolism Receptors, G-Protein-Coupled - metabolism Receptors, G-Protein-Coupled - physiology Recombination, Genetic RNA - metabolism Serine - chemistry Time Factors
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