Higher Concentration of HIV RNA in Rectal Mucosa Secretions than in Blood and Seminal Plasma, among Men Who Have Sex with Men, Independent of Antiretroviral Therapy
High levels of human immunodeficiency virus (HIV) in rectal secretions and semen likely increase the risk of HIV transmission. HIV-infected men who have sex with men made 2–3 study visits, over 4 weeks, to assess rectal, seminal, and plasma levels of HIV RNA. Mixed-effects models estimated the effec...
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| Veröffentlicht in: | The Journal of infectious diseases 2004-07, Vol.190 (1), p.156-161 |
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| container_title | The Journal of infectious diseases |
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| creator | Zuckerman, Richard A. Whittington, William L. H. Celum, Connie L. Collis, Tarquin K. Lucchetti, Aldo J. Sanchez, Jorge L. Hughes, James P. Sanchez, Jose L. Coombs, Robert W. |
| description | High levels of human immunodeficiency virus (HIV) in rectal secretions and semen likely increase the risk of HIV transmission. HIV-infected men who have sex with men made 2–3 study visits, over 4 weeks, to assess rectal, seminal, and plasma levels of HIV RNA. Mixed-effects models estimated the effect of factors on HIV shedding. Twenty-seven (42%) of 64 men were receiving antiretroviral therapy (ART); regardless of ART use, median HIV RNA levels were higher in rectal secretions (4.96 log10 copies/mL) than in blood plasma (4.24 log10 copies/mL) or seminal plasma (3.55 log10 copies/mL; P< .05, each comparison). ART was associated with a 1.3-log10 reduction in rectal HIV RNA in a model without plasma HIV RNA; with and without plasma RNA in models, ART accounted for a >1-log10 decrease in seminal HIV RNA levels. Thus, controlling for plasma HIV RNA, ART had an independent effect on seminal, but not rectal, HIV levels. |
| doi_str_mv | 10.1086/421246 |
| format | Article |
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Twenty-seven (42%) of 64 men were receiving antiretroviral therapy (ART); regardless of ART use, median HIV RNA levels were higher in rectal secretions (4.96 log10 copies/mL) than in blood plasma (4.24 log10 copies/mL) or seminal plasma (3.55 log10 copies/mL; P< .05, each comparison). ART was associated with a 1.3-log10 reduction in rectal HIV RNA in a model without plasma HIV RNA; with and without plasma RNA in models, ART accounted for a >1-log10 decrease in seminal HIV RNA levels. Thus, controlling for plasma HIV RNA, ART had an independent effect on seminal, but not rectal, HIV levels.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/421246</identifier><identifier>PMID: 15195255</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Adult ; AIDS ; Anti-HIV Agents - therapeutic use ; Arts ; Biological and medical sciences ; Blood ; Blood plasma ; Fundamental and applied biological sciences. Psychology ; HIV ; HIV 1 ; HIV Infections - drug therapy ; HIV Infections - transmission ; HIV Infections - virology ; HIV-1 - genetics ; HIV-1 - isolation & purification ; HIV/AIDS ; Homosexuality ; Human immunodeficiency virus ; Humans ; Infectious diseases ; Male ; Medical sciences ; Microbiology ; Middle Aged ; Miscellaneous ; Mucous Membrane - virology ; Rectum - virology ; RNA ; RNA, Viral - analysis ; RNA, Viral - blood ; Secretion ; Semen - virology ; Seminal plasma ; Specimens ; Virology</subject><ispartof>The Journal of infectious diseases, 2004-07, Vol.190 (1), p.156-161</ispartof><rights>Copyright 2004 Infectious Diseases Society of America</rights><rights>2004 by the Infectious Diseases Society of America 2004</rights><rights>2004 INIST-CNRS</rights><rights>Copyright University of Chicago Press Jul 1, 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-3a4ef023464ff88676420538e7c16c91b1029e17c57f91394a9bb1ab5cbd6dd3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30077597$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30077597$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15995847$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15195255$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zuckerman, Richard A.</creatorcontrib><creatorcontrib>Whittington, William L. H.</creatorcontrib><creatorcontrib>Celum, Connie L.</creatorcontrib><creatorcontrib>Collis, Tarquin K.</creatorcontrib><creatorcontrib>Lucchetti, Aldo J.</creatorcontrib><creatorcontrib>Sanchez, Jorge L.</creatorcontrib><creatorcontrib>Hughes, James P.</creatorcontrib><creatorcontrib>Sanchez, Jose L.</creatorcontrib><creatorcontrib>Coombs, Robert W.</creatorcontrib><title>Higher Concentration of HIV RNA in Rectal Mucosa Secretions than in Blood and Seminal Plasma, among Men Who Have Sex with Men, Independent of Antiretroviral Therapy</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><addtitle>The Journal of Infectious Diseases</addtitle><description>High levels of human immunodeficiency virus (HIV) in rectal secretions and semen likely increase the risk of HIV transmission. HIV-infected men who have sex with men made 2–3 study visits, over 4 weeks, to assess rectal, seminal, and plasma levels of HIV RNA. 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Psychology</subject><subject>HIV</subject><subject>HIV 1</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - transmission</subject><subject>HIV Infections - virology</subject><subject>HIV-1 - genetics</subject><subject>HIV-1 - isolation & purification</subject><subject>HIV/AIDS</subject><subject>Homosexuality</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Mucous Membrane - virology</subject><subject>Rectum - virology</subject><subject>RNA</subject><subject>RNA, Viral - analysis</subject><subject>RNA, Viral - blood</subject><subject>Secretion</subject><subject>Semen - virology</subject><subject>Seminal plasma</subject><subject>Specimens</subject><subject>Virology</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0d1u0zAUB_AIgVgZ8AYggwRXC_gzji9LBbTQDbRVgHYTOY6zuiR2sZ2xvQ8PiqNWG0JC3NiSz0__c-STZY8RfIVgWbymGGFa3MkmiBGeFwUid7MJhBjnqBTiIHsQwgZCSEnB72cHiCHBMGOT7NfcXKy1BzNnlbbRy2icBa4F88UXcHoyBcaCU62i7MDxoFyQ4Ewrr0cVQFxLO4I3nXMNkLZJxd7YZD93MvTyCMje2QtwrC34unZgLi91Ilfgp4nr8fUILGyjtzodNo5dpzaalO7dpfEpZpVGk9vrh9m9VnZBP9rfh9nq3dvVbJ4vP71fzKbLXNESxZxIqluICS1o25ZlwQuKISOl5goVSqAaQSw04orxViAiqBR1jWTNVN0UTUMOs5e72K13PwYdYtWboHTXSavdECqOIaac8_9CxIUoESQJPv8Lbtzg0weFCmMioGAU36Yp70Lwuq223vTSX1cIVuNyq91yE3y6TxvqXje3bL_NBF7sgQxKdq2XVpnwhxOClXSc_9nOuWH772ZPdmYTovM3ikDIORNjRr6rmxD11U1d-u9VwQln1fzbeUU-nJ0vyQmvPpLfqe_M1w</recordid><startdate>20040701</startdate><enddate>20040701</enddate><creator>Zuckerman, Richard A.</creator><creator>Whittington, William L. 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Psychology</topic><topic>HIV</topic><topic>HIV 1</topic><topic>HIV Infections - drug therapy</topic><topic>HIV Infections - transmission</topic><topic>HIV Infections - virology</topic><topic>HIV-1 - genetics</topic><topic>HIV-1 - isolation & purification</topic><topic>HIV/AIDS</topic><topic>Homosexuality</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Mucous Membrane - virology</topic><topic>Rectum - virology</topic><topic>RNA</topic><topic>RNA, Viral - analysis</topic><topic>RNA, Viral - blood</topic><topic>Secretion</topic><topic>Semen - virology</topic><topic>Seminal plasma</topic><topic>Specimens</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zuckerman, Richard A.</creatorcontrib><creatorcontrib>Whittington, William L. 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H.</au><au>Celum, Connie L.</au><au>Collis, Tarquin K.</au><au>Lucchetti, Aldo J.</au><au>Sanchez, Jorge L.</au><au>Hughes, James P.</au><au>Sanchez, Jose L.</au><au>Coombs, Robert W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Higher Concentration of HIV RNA in Rectal Mucosa Secretions than in Blood and Seminal Plasma, among Men Who Have Sex with Men, Independent of Antiretroviral Therapy</atitle><jtitle>The Journal of infectious diseases</jtitle><stitle>The Journal of Infectious Diseases</stitle><addtitle>The Journal of Infectious Diseases</addtitle><date>2004-07-01</date><risdate>2004</risdate><volume>190</volume><issue>1</issue><spage>156</spage><epage>161</epage><pages>156-161</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>High levels of human immunodeficiency virus (HIV) in rectal secretions and semen likely increase the risk of HIV transmission. HIV-infected men who have sex with men made 2–3 study visits, over 4 weeks, to assess rectal, seminal, and plasma levels of HIV RNA. Mixed-effects models estimated the effect of factors on HIV shedding. Twenty-seven (42%) of 64 men were receiving antiretroviral therapy (ART); regardless of ART use, median HIV RNA levels were higher in rectal secretions (4.96 log10 copies/mL) than in blood plasma (4.24 log10 copies/mL) or seminal plasma (3.55 log10 copies/mL; P< .05, each comparison). ART was associated with a 1.3-log10 reduction in rectal HIV RNA in a model without plasma HIV RNA; with and without plasma RNA in models, ART accounted for a >1-log10 decrease in seminal HIV RNA levels. Thus, controlling for plasma HIV RNA, ART had an independent effect on seminal, but not rectal, HIV levels.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>15195255</pmid><doi>10.1086/421246</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of infectious diseases, 2004-07, Vol.190 (1), p.156-161 |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Adult AIDS Anti-HIV Agents - therapeutic use Arts Biological and medical sciences Blood Blood plasma Fundamental and applied biological sciences. Psychology HIV HIV 1 HIV Infections - drug therapy HIV Infections - transmission HIV Infections - virology HIV-1 - genetics HIV-1 - isolation & purification HIV/AIDS Homosexuality Human immunodeficiency virus Humans Infectious diseases Male Medical sciences Microbiology Middle Aged Miscellaneous Mucous Membrane - virology Rectum - virology RNA RNA, Viral - analysis RNA, Viral - blood Secretion Semen - virology Seminal plasma Specimens Virology |
| title | Higher Concentration of HIV RNA in Rectal Mucosa Secretions than in Blood and Seminal Plasma, among Men Who Have Sex with Men, Independent of Antiretroviral Therapy |
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