Follicular Dendritic Cell-Mediated Up-Regulation of CXCR4 Expression on CD4 T Cells and HIV Pathogenesis

Follicular dendritic cells (FDCs) represent a major reservoir of HIV, and active infection occurs surrounding these cells, suggesting that this microenvironment is highly conducive to virus transmission. Because CD4 T cells around FDCs in germinal centers express the HIV coreceptor, CXCR4, whereas C...

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Veröffentlicht in:	The Journal of immunology (1950) 2002-09, Vol.169 (5), p.2313-2322
Hauptverfasser:	Estes, Jacob D, Keele, Brandon F, Tenner-Racz, Klara, Racz, Paul, Redd, Michael A, Thacker, Tyler C, Jiang, Yongjun, Lloyd, Michael J, Gartner, Suzanne, Burton, Gregory F
Format:	Artikel
Sprache:	eng
Schlagworte:	CD4 Antigens - biosynthesis CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism CD4-Positive T-Lymphocytes - virology Cells, Cultured Coculture Techniques Dendritic Cells, Follicular - immunology Disease Susceptibility - immunology Germinal Center - cytology Germinal Center - immunology Germinal Center - metabolism HIV Infections - immunology HIV Infections - virology HIV-1 - immunology HIV-1 - pathogenicity Humans Membrane Fusion - immunology Palatine Tonsil Receptors, CCR5 - biosynthesis Receptors, CXCR4 - biosynthesis T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism T-Lymphocyte Subsets - virology Up-Regulation - immunology
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