Parkinson's disease in Ireland: Clinical presentation and genetic heterogeneity in patients with parkin mutations

Early‐onset autosomal recessive parkinsonism is associated with parkin gene mutations. Different parkin mutations occur in many ethnic backgrounds; however, the phenotype may vary. We studied 102 young‐onset (age at onset

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Bibliographische Detailangaben
Veröffentlicht in:	Movement disorders 2004-06, Vol.19 (6), p.677-681
Hauptverfasser:	Wiley, Joseph, Lynch, Timothy, Lincoln, Sarah, Skipper, Lisa, Hulihan, Mary, Gosal, David, Bisceglio, Gina, Kachergus, Jennifer, Hardy, John, Farrer, Matthew J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Biological and medical sciences DNA Mutational Analysis Female Genetic Heterogeneity genetics Humans Ireland - epidemiology Male Medical sciences Middle Aged Neurology parkin Parkinson Disease - epidemiology Parkinson Disease - genetics Parkinson Disease - physiopathology Parkinson's disease Point Mutation - genetics Ubiquitin-Protein Ligases - genetics
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Zusammenfassung:	Early‐onset autosomal recessive parkinsonism is associated with parkin gene mutations. Different parkin mutations occur in many ethnic backgrounds; however, the phenotype may vary. We studied 102 young‐onset (age at onset
ISSN:	0885-3185 1531-8257
DOI:	10.1002/mds.10703