Abnormal Fhit protein expression and high frequency of microsatellite instability in sporadic colorectal cancer

The role of Fhit protein in the oncogenesis of colorectal cancer is still in debate. Recent studies have revealed that reduced Fhit protein expression is associated with a deficiency of the mismatch repair protein. One hundred and twenty unselected patients who underwent curative resection for spora...

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Veröffentlicht in:	European journal of cancer (1990) 2004-07, Vol.40 (10), p.1581-1588
Hauptverfasser:	Sarli, Leopoldo, Bottarelli, Lorena, Azzoni, Cinzia, Campanini, Nicoletta, Di Cola, Gabriella, Bader, Giovanni, Iusco, Domenico, Salvemini, Carlo, Caruso, Giuseppe, Donadei, Enrico, Pizzi, Silvia, D'Adda, Tiziana, Renato, Costi, Roncoroni, Luigi, Bordi, Cesare
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid Anhydride Hydrolases - genetics Acid Anhydride Hydrolases - metabolism Adaptor Proteins, Signal Transducing Adult Aged Aged, 80 and over Base Pair Mismatch - genetics Biological and medical sciences Carrier Proteins Colorectal cancer Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism DNA-Binding Proteins - metabolism Female FHIT Gastroenterology. Liver. Pancreas. Abdomen Gene Expression hMLH1 hMSH2 Humans Immunohistochemistry Loss of Heterozygosity - genetics Male Medical sciences Microsatellite Repeats - genetics Middle Aged MSI MutL Protein Homolog 1 MutS Homolog 2 Protein Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Nuclear Proteins Pharmacology. Drug treatments Polymerase Chain Reaction - methods Proto-Oncogene Proteins - metabolism Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors
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