Cobalt-Protoporphyrin treatment renders islets tolerant to interleukin-1 beta suppression
This study examined whether treating donor mice with a single dose of cobalt protoporphyrin (CoPP) induced heme oxygenase-1 (HO-1) and protected islet cells from interleukin-1 beta (IL-1β) suppression. Islets were isolated from mice receiving a single dose of either CoPP (20 mg/kg of body weight, Co...
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| Veröffentlicht in: | Transplantation proceedings 2004-05, Vol.36 (4), p.1181-1182 |
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| creator | Hsu, B.R.-S Juang, J.-H Chen, S.-T Hsu, S Fu, S.-H |
| description | This study examined whether treating donor mice with a single dose of cobalt protoporphyrin (CoPP) induced heme oxygenase-1 (HO-1) and protected islet cells from interleukin-1 beta (IL-1β) suppression. Islets were isolated from mice receiving a single dose of either CoPP (20 mg/kg of body weight, CoPP islets) or isotonic NaCl solution vehicle (control islets), 24 hours before isolation. Glucose-stimulated insulin secretion (GSIS) and insulin content (IC) of the islets were determined following incubation in the presence versus absence of murine IL-1β for 21 or 65 hours. The HO-1 protein level of CoPP-induced islets, as determined by an enzyme immunoassay, was significantly higher than that of control islets at 12 hours (
P < .01) and 30 hours (
P < .05), and returned to basal levels at 56 hours (
P = NS). Following a 21-hour incubation with IL-1β, CoPP islets secreted significantly more insulin upon glucose stimulation and preserved significantly more IC than control islets. After 65-hour incubation with IL-1β, CoPP islets secreted significantly less insulin upon glucose stimulation than control islets and preserved significantly less IC compared to islets incubated without IL-1β. In conclusion, treatment with cobalt-protoporphyrin to induce heme oxygenase-1 protects islets against the suppressive effects of IL-1β. |
| doi_str_mv | 10.1016/j.transproceed.2004.04.037 |
| format | Article |
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P < .01) and 30 hours (
P < .05), and returned to basal levels at 56 hours (
P = NS). Following a 21-hour incubation with IL-1β, CoPP islets secreted significantly more insulin upon glucose stimulation and preserved significantly more IC than control islets. After 65-hour incubation with IL-1β, CoPP islets secreted significantly less insulin upon glucose stimulation than control islets and preserved significantly less IC compared to islets incubated without IL-1β. In conclusion, treatment with cobalt-protoporphyrin to induce heme oxygenase-1 protects islets against the suppressive effects of IL-1β.</description><identifier>ISSN: 0041-1345</identifier><identifier>EISSN: 1873-2623</identifier><identifier>DOI: 10.1016/j.transproceed.2004.04.037</identifier><identifier>PMID: 15194409</identifier><identifier>CODEN: TRPPA8</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Immune Tolerance ; Immunosuppression ; Insulin - metabolism ; Insulin Secretion ; Interleukin-1 - pharmacology ; Islets of Langerhans - drug effects ; Islets of Langerhans - immunology ; Islets of Langerhans - metabolism ; Kinetics ; Management. Various non-drug treatments. Langerhans islet grafts ; Medical sciences ; Mice ; Mice, Inbred C57BL ; Protoporphyrins - pharmacology ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Time Factors</subject><ispartof>Transplantation proceedings, 2004-05, Vol.36 (4), p.1181-1182</ispartof><rights>2004 Elsevier Inc.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-e192d6aa8f6012114813df7bbafc47f17a5fb7cddf418df8d8f1a0f83b50c2023</citedby><cites>FETCH-LOGICAL-c406t-e192d6aa8f6012114813df7bbafc47f17a5fb7cddf418df8d8f1a0f83b50c2023</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.transproceed.2004.04.037$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,3550,23930,23931,25140,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15870726$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15194409$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hsu, B.R.-S</creatorcontrib><creatorcontrib>Juang, J.-H</creatorcontrib><creatorcontrib>Chen, S.-T</creatorcontrib><creatorcontrib>Hsu, S</creatorcontrib><creatorcontrib>Fu, S.-H</creatorcontrib><title>Cobalt-Protoporphyrin treatment renders islets tolerant to interleukin-1 beta suppression</title><title>Transplantation proceedings</title><addtitle>Transplant Proc</addtitle><description>This study examined whether treating donor mice with a single dose of cobalt protoporphyrin (CoPP) induced heme oxygenase-1 (HO-1) and protected islet cells from interleukin-1 beta (IL-1β) suppression. Islets were isolated from mice receiving a single dose of either CoPP (20 mg/kg of body weight, CoPP islets) or isotonic NaCl solution vehicle (control islets), 24 hours before isolation. Glucose-stimulated insulin secretion (GSIS) and insulin content (IC) of the islets were determined following incubation in the presence versus absence of murine IL-1β for 21 or 65 hours. The HO-1 protein level of CoPP-induced islets, as determined by an enzyme immunoassay, was significantly higher than that of control islets at 12 hours (
P < .01) and 30 hours (
P < .05), and returned to basal levels at 56 hours (
P = NS). Following a 21-hour incubation with IL-1β, CoPP islets secreted significantly more insulin upon glucose stimulation and preserved significantly more IC than control islets. After 65-hour incubation with IL-1β, CoPP islets secreted significantly less insulin upon glucose stimulation than control islets and preserved significantly less IC compared to islets incubated without IL-1β. In conclusion, treatment with cobalt-protoporphyrin to induce heme oxygenase-1 protects islets against the suppressive effects of IL-1β.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Immune Tolerance</subject><subject>Immunosuppression</subject><subject>Insulin - metabolism</subject><subject>Insulin Secretion</subject><subject>Interleukin-1 - pharmacology</subject><subject>Islets of Langerhans - drug effects</subject><subject>Islets of Langerhans - immunology</subject><subject>Islets of Langerhans - metabolism</subject><subject>Kinetics</subject><subject>Management. Various non-drug treatments. Langerhans islet grafts</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Protoporphyrins - pharmacology</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Time Factors</subject><issn>0041-1345</issn><issn>1873-2623</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMGKFDEQhoMo7uzqK0gj6K1nU0mm0-NNRl0XFtyDHjyFdFLBjD2dNpVe2Lc3wwyyR6EgCfXVX-Fj7C3wNXDorvfrku1Ec04O0a8F52p9LKmfsRX0WraiE_I5W9UGtCDV5oJdEu15fQslX7IL2MBWKb5dsZ-7NNixtPc5lTSnPP96zHFqSkZbDjiVJuPkMVMTacRCTUkj1uWlXpo4FcwjLr_j1EIzYLENLfOckSim6RV7EexI-Pp8XrEfXz5_331t777d3O4-3rVO8a60CFvhO2v70HEQAKoH6YMeBhuc0gG03YRBO--Dgt6H3vcBLA-9HDbcCS7kFXt_yq0-_ixIxRwiORxHO2FayOgKqRpbwQ8n0OVElDGYOceDzY8GuDmKNXvzVKw5ijXHkroOvzlvWYZD7f0bPZuswLszYMnZMdQgF-kJ12uuRVe5TycOq5OHiNmQizg59DGjK8an-D__-QvfpKBx</recordid><startdate>20040501</startdate><enddate>20040501</enddate><creator>Hsu, B.R.-S</creator><creator>Juang, J.-H</creator><creator>Chen, S.-T</creator><creator>Hsu, S</creator><creator>Fu, S.-H</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040501</creationdate><title>Cobalt-Protoporphyrin treatment renders islets tolerant to interleukin-1 beta suppression</title><author>Hsu, B.R.-S ; Juang, J.-H ; Chen, S.-T ; Hsu, S ; Fu, S.-H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-e192d6aa8f6012114813df7bbafc47f17a5fb7cddf418df8d8f1a0f83b50c2023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Immune Tolerance</topic><topic>Immunosuppression</topic><topic>Insulin - metabolism</topic><topic>Insulin Secretion</topic><topic>Interleukin-1 - pharmacology</topic><topic>Islets of Langerhans - drug effects</topic><topic>Islets of Langerhans - immunology</topic><topic>Islets of Langerhans - metabolism</topic><topic>Kinetics</topic><topic>Management. Various non-drug treatments. Langerhans islet grafts</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Protoporphyrins - pharmacology</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hsu, B.R.-S</creatorcontrib><creatorcontrib>Juang, J.-H</creatorcontrib><creatorcontrib>Chen, S.-T</creatorcontrib><creatorcontrib>Hsu, S</creatorcontrib><creatorcontrib>Fu, S.-H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation proceedings</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hsu, B.R.-S</au><au>Juang, J.-H</au><au>Chen, S.-T</au><au>Hsu, S</au><au>Fu, S.-H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cobalt-Protoporphyrin treatment renders islets tolerant to interleukin-1 beta suppression</atitle><jtitle>Transplantation proceedings</jtitle><addtitle>Transplant Proc</addtitle><date>2004-05-01</date><risdate>2004</risdate><volume>36</volume><issue>4</issue><spage>1181</spage><epage>1182</epage><pages>1181-1182</pages><issn>0041-1345</issn><eissn>1873-2623</eissn><coden>TRPPA8</coden><abstract>This study examined whether treating donor mice with a single dose of cobalt protoporphyrin (CoPP) induced heme oxygenase-1 (HO-1) and protected islet cells from interleukin-1 beta (IL-1β) suppression. Islets were isolated from mice receiving a single dose of either CoPP (20 mg/kg of body weight, CoPP islets) or isotonic NaCl solution vehicle (control islets), 24 hours before isolation. Glucose-stimulated insulin secretion (GSIS) and insulin content (IC) of the islets were determined following incubation in the presence versus absence of murine IL-1β for 21 or 65 hours. The HO-1 protein level of CoPP-induced islets, as determined by an enzyme immunoassay, was significantly higher than that of control islets at 12 hours (
P < .01) and 30 hours (
P < .05), and returned to basal levels at 56 hours (
P = NS). Following a 21-hour incubation with IL-1β, CoPP islets secreted significantly more insulin upon glucose stimulation and preserved significantly more IC than control islets. After 65-hour incubation with IL-1β, CoPP islets secreted significantly less insulin upon glucose stimulation than control islets and preserved significantly less IC compared to islets incubated without IL-1β. In conclusion, treatment with cobalt-protoporphyrin to induce heme oxygenase-1 protects islets against the suppressive effects of IL-1β.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>15194409</pmid><doi>10.1016/j.transproceed.2004.04.037</doi><tpages>2</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Immune Tolerance Immunosuppression Insulin - metabolism Insulin Secretion Interleukin-1 - pharmacology Islets of Langerhans - drug effects Islets of Langerhans - immunology Islets of Langerhans - metabolism Kinetics Management. Various non-drug treatments. Langerhans islet grafts Medical sciences Mice Mice, Inbred C57BL Protoporphyrins - pharmacology Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Time Factors |
| title | Cobalt-Protoporphyrin treatment renders islets tolerant to interleukin-1 beta suppression |
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