Mechanisms of Tamoxifen Resistance: Increased Estrogen Receptor-HER2/neu Cross-Talk in ER/HER2–Positive Breast Cancer

Background: Patients receiving adjuvant tamoxifen whose tumors express high levels of both HER2/neu (HER2) and the estrogen receptor (ER) coactivator AIB1 often develop tamoxifen resistance. We used a breast cancer model system with high expression of AIB1 and HER2 to investigate the possible mechan...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 2004-06, Vol.96 (12), p.926-935
Hauptverfasser:	Shou, Jiang, Massarweh, Suleiman, Osborne, C. Kent, Wakeling, Alan E., Ali, Simale, Weiss, Heidi, Schiff, Rachel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Antineoplastic Agents, Hormonal - pharmacology Biological and medical sciences Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Cell Line, Tumor Cells Chemotherapy Chemotherapy, Adjuvant Drug resistance Drug Resistance, Neoplasm Enzyme Inhibitors - pharmacology Epidermal Growth Factor - antagonists & inhibitors Estrogen Receptor Modulators - pharmacology Estrogens Female Gefitinib Gene Expression Regulation, Neoplastic - drug effects Humans Medical sciences Mice Mice, Inbred BALB C Mice, Nude Pharmacology. Drug treatments Phosphorylation - drug effects Protein-Tyrosine Kinases - antagonists & inhibitors Quinazolines - pharmacology Receptor Cross-Talk - drug effects Receptor, ErbB-2 - drug effects Receptor, ErbB-2 - metabolism Receptors, Estrogen - drug effects Receptors, Estrogen - metabolism Signal Transduction - drug effects Tamoxifen - pharmacology Transplantation, Heterologous Tumors Up-Regulation - drug effects
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