Intracellular target for photosensitization in cancer antiangiogenic photodynamic therapy mediated by polycation liposome
Previous study indicated that antiangiogenic photodynamic therapy (PDT), laser irradiation at 15 min post-injection of photosensitizer in vivo, is effective for cancer treatment, and a photosensitizer, benzoporphyrin derivative monoacid ring A (BPD-MA), encapsulated in polycation liposomes (PCLs), l...
Gespeichert in:
| Veröffentlicht in: | Journal of controlled release 2004-06, Vol.97 (2), p.231-240 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 240 |
|---|---|
| container_issue | 2 |
| container_start_page | 231 |
| container_title | Journal of controlled release |
| container_volume | 97 |
| creator | Takeuchi, Yoshito Ichikawa, Kanae Yonezawa, Sei Kurohane, Kohta Koishi, Takayuki Nango, Mamoru Namba, Yukihiro Oku, Naoto |
| description | Previous study indicated that antiangiogenic photodynamic therapy (PDT), laser irradiation at 15 min post-injection of photosensitizer in vivo, is effective for cancer treatment, and a photosensitizer, benzoporphyrin derivative monoacid ring A (BPD-MA), encapsulated in polycation liposomes (PCLs), liposomes modified with cetylated polyethylenimine (cetyl-PEI), is more effective than BPD-MA encapsulated in non-modified liposomes [Cancer 97 (2003) 2027]. In the present study, we examined intracellular distribution of BPD-MA. BPD-MA encapsulated in liposomes or in PCLs was incubated with human endothelial cell line ECV304 cells or human umbilical vein endothelial cells (HUVECs), and monitored the intracellular distribution of BPD-MA by confocal laser scan microscopy. BPD-MA was taken up time-dependently into the cells and was distributed in not only cytoplasmic area but also intranuclear region. The enhanced uptake of BPD-MA was observed by the PCL formulation. Intracellular distribution of polycation was monitored by using fluorescein isothiocyanate-labeled cetyl-PEI (cetyl-PEI-FITC) and was colocalized with BPD-MA. Cytoplasmic BPD-MA distribution was partly overlapped with that of rhodamine 123, a mitochondrial fluorostaining probe, suggesting that mitochondrial photosensitization as well as nuclear photosensitization, is involved in the antiangiogenic PDT treatment. |
| doi_str_mv | 10.1016/j.jconrel.2004.03.030 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72023822</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0168365904001646</els_id><sourcerecordid>72023822</sourcerecordid><originalsourceid>FETCH-LOGICAL-c403t-6162c09e41a78116c921e02b0ce4c140bb1d0b7e94ae317e05093eb514e86c963</originalsourceid><addsrcrecordid>eNqFkU1r3DAQhkVpaTZpf0KLL-3N29GXP06lhCYNBHpJzkKWZzdabMmVtAXn11fGhvQWGBCCZ0aj9yHkE4U9BVp9O-1PxruAw54BiD3wXPCG7GhT81K0rXxLdplrSl7J9oJcxngCAMlF_Z5cUEnbqpawI_OdS0EbHIbzoEORdDhiKg4-FNOTTz6iizbZZ52sd4V1hdHOYCi0S1a7o_VHdNasbD87PeZLesKgp7kYsbc6YV90czH5YTbrkMFOPvoRP5B3Bz1E_LidV-Tx5ufD9a_y_vft3fWP-9II4KmsaMUMtCiorhtKK9MyisA6MCgMFdB1tIeuxlZo5LRGkNBy7CQV2GS44lfk6zp3Cv7PGWNSo43Lh7VDf46qZsB4w9irIK0r4JJBBuUKmuBjDHhQU7CjDrOioBY56qQ2OWqRo4DnWvo-bw-cuxzOS9dmIwNfNkBHo4dDyGHb-B_XSCHqhfu-cphz-2sxqGgsZjG9DWiS6r19ZZV_s9Gyug</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17603520</pqid></control><display><type>article</type><title>Intracellular target for photosensitization in cancer antiangiogenic photodynamic therapy mediated by polycation liposome</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Takeuchi, Yoshito ; Ichikawa, Kanae ; Yonezawa, Sei ; Kurohane, Kohta ; Koishi, Takayuki ; Nango, Mamoru ; Namba, Yukihiro ; Oku, Naoto</creator><creatorcontrib>Takeuchi, Yoshito ; Ichikawa, Kanae ; Yonezawa, Sei ; Kurohane, Kohta ; Koishi, Takayuki ; Nango, Mamoru ; Namba, Yukihiro ; Oku, Naoto</creatorcontrib><description>Previous study indicated that antiangiogenic photodynamic therapy (PDT), laser irradiation at 15 min post-injection of photosensitizer in vivo, is effective for cancer treatment, and a photosensitizer, benzoporphyrin derivative monoacid ring A (BPD-MA), encapsulated in polycation liposomes (PCLs), liposomes modified with cetylated polyethylenimine (cetyl-PEI), is more effective than BPD-MA encapsulated in non-modified liposomes [Cancer 97 (2003) 2027]. In the present study, we examined intracellular distribution of BPD-MA. BPD-MA encapsulated in liposomes or in PCLs was incubated with human endothelial cell line ECV304 cells or human umbilical vein endothelial cells (HUVECs), and monitored the intracellular distribution of BPD-MA by confocal laser scan microscopy. BPD-MA was taken up time-dependently into the cells and was distributed in not only cytoplasmic area but also intranuclear region. The enhanced uptake of BPD-MA was observed by the PCL formulation. Intracellular distribution of polycation was monitored by using fluorescein isothiocyanate-labeled cetyl-PEI (cetyl-PEI-FITC) and was colocalized with BPD-MA. Cytoplasmic BPD-MA distribution was partly overlapped with that of rhodamine 123, a mitochondrial fluorostaining probe, suggesting that mitochondrial photosensitization as well as nuclear photosensitization, is involved in the antiangiogenic PDT treatment.</description><identifier>ISSN: 0168-3659</identifier><identifier>EISSN: 1873-4995</identifier><identifier>DOI: 10.1016/j.jconrel.2004.03.030</identifier><identifier>PMID: 15196750</identifier><identifier>CODEN: JCREEC</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Benzoporphyrin derivative monoacid ring A (BPD-MA) ; Biological and medical sciences ; Cells, Cultured ; Endothelium, Vascular - cytology ; Endothelium, Vascular - metabolism ; General pharmacology ; Humans ; Liposomes ; Medical sciences ; Microscopy, Confocal ; Mitochondria - metabolism ; Neovascularization, Pathologic - therapy ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Photochemotherapy ; Photodynamic therapy (PDT) ; Photosensitizing Agents - chemistry ; Photosensitizing Agents - pharmacokinetics ; Polycation liposome (PCL) ; Polyethyleneimine - chemistry ; Polyethyleneimine - pharmacokinetics ; Polyethylenimine (PEI) ; Porphyrins - chemistry ; Porphyrins - pharmacokinetics ; Time Factors</subject><ispartof>Journal of controlled release, 2004-06, Vol.97 (2), p.231-240</ispartof><rights>2004 Elsevier B.V.</rights><rights>2004 INIST-CNRS</rights><rights>Copyright 2004 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c403t-6162c09e41a78116c921e02b0ce4c140bb1d0b7e94ae317e05093eb514e86c963</citedby><cites>FETCH-LOGICAL-c403t-6162c09e41a78116c921e02b0ce4c140bb1d0b7e94ae317e05093eb514e86c963</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0168365904001646$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15854470$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15196750$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Takeuchi, Yoshito</creatorcontrib><creatorcontrib>Ichikawa, Kanae</creatorcontrib><creatorcontrib>Yonezawa, Sei</creatorcontrib><creatorcontrib>Kurohane, Kohta</creatorcontrib><creatorcontrib>Koishi, Takayuki</creatorcontrib><creatorcontrib>Nango, Mamoru</creatorcontrib><creatorcontrib>Namba, Yukihiro</creatorcontrib><creatorcontrib>Oku, Naoto</creatorcontrib><title>Intracellular target for photosensitization in cancer antiangiogenic photodynamic therapy mediated by polycation liposome</title><title>Journal of controlled release</title><addtitle>J Control Release</addtitle><description>Previous study indicated that antiangiogenic photodynamic therapy (PDT), laser irradiation at 15 min post-injection of photosensitizer in vivo, is effective for cancer treatment, and a photosensitizer, benzoporphyrin derivative monoacid ring A (BPD-MA), encapsulated in polycation liposomes (PCLs), liposomes modified with cetylated polyethylenimine (cetyl-PEI), is more effective than BPD-MA encapsulated in non-modified liposomes [Cancer 97 (2003) 2027]. In the present study, we examined intracellular distribution of BPD-MA. BPD-MA encapsulated in liposomes or in PCLs was incubated with human endothelial cell line ECV304 cells or human umbilical vein endothelial cells (HUVECs), and monitored the intracellular distribution of BPD-MA by confocal laser scan microscopy. BPD-MA was taken up time-dependently into the cells and was distributed in not only cytoplasmic area but also intranuclear region. The enhanced uptake of BPD-MA was observed by the PCL formulation. Intracellular distribution of polycation was monitored by using fluorescein isothiocyanate-labeled cetyl-PEI (cetyl-PEI-FITC) and was colocalized with BPD-MA. Cytoplasmic BPD-MA distribution was partly overlapped with that of rhodamine 123, a mitochondrial fluorostaining probe, suggesting that mitochondrial photosensitization as well as nuclear photosensitization, is involved in the antiangiogenic PDT treatment.</description><subject>Benzoporphyrin derivative monoacid ring A (BPD-MA)</subject><subject>Biological and medical sciences</subject><subject>Cells, Cultured</subject><subject>Endothelium, Vascular - cytology</subject><subject>Endothelium, Vascular - metabolism</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>Liposomes</subject><subject>Medical sciences</subject><subject>Microscopy, Confocal</subject><subject>Mitochondria - metabolism</subject><subject>Neovascularization, Pathologic - therapy</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Photochemotherapy</subject><subject>Photodynamic therapy (PDT)</subject><subject>Photosensitizing Agents - chemistry</subject><subject>Photosensitizing Agents - pharmacokinetics</subject><subject>Polycation liposome (PCL)</subject><subject>Polyethyleneimine - chemistry</subject><subject>Polyethyleneimine - pharmacokinetics</subject><subject>Polyethylenimine (PEI)</subject><subject>Porphyrins - chemistry</subject><subject>Porphyrins - pharmacokinetics</subject><subject>Time Factors</subject><issn>0168-3659</issn><issn>1873-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1r3DAQhkVpaTZpf0KLL-3N29GXP06lhCYNBHpJzkKWZzdabMmVtAXn11fGhvQWGBCCZ0aj9yHkE4U9BVp9O-1PxruAw54BiD3wXPCG7GhT81K0rXxLdplrSl7J9oJcxngCAMlF_Z5cUEnbqpawI_OdS0EbHIbzoEORdDhiKg4-FNOTTz6iizbZZ52sd4V1hdHOYCi0S1a7o_VHdNasbD87PeZLesKgp7kYsbc6YV90czH5YTbrkMFOPvoRP5B3Bz1E_LidV-Tx5ufD9a_y_vft3fWP-9II4KmsaMUMtCiorhtKK9MyisA6MCgMFdB1tIeuxlZo5LRGkNBy7CQV2GS44lfk6zp3Cv7PGWNSo43Lh7VDf46qZsB4w9irIK0r4JJBBuUKmuBjDHhQU7CjDrOioBY56qQ2OWqRo4DnWvo-bw-cuxzOS9dmIwNfNkBHo4dDyGHb-B_XSCHqhfu-cphz-2sxqGgsZjG9DWiS6r19ZZV_s9Gyug</recordid><startdate>20040618</startdate><enddate>20040618</enddate><creator>Takeuchi, Yoshito</creator><creator>Ichikawa, Kanae</creator><creator>Yonezawa, Sei</creator><creator>Kurohane, Kohta</creator><creator>Koishi, Takayuki</creator><creator>Nango, Mamoru</creator><creator>Namba, Yukihiro</creator><creator>Oku, Naoto</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20040618</creationdate><title>Intracellular target for photosensitization in cancer antiangiogenic photodynamic therapy mediated by polycation liposome</title><author>Takeuchi, Yoshito ; Ichikawa, Kanae ; Yonezawa, Sei ; Kurohane, Kohta ; Koishi, Takayuki ; Nango, Mamoru ; Namba, Yukihiro ; Oku, Naoto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c403t-6162c09e41a78116c921e02b0ce4c140bb1d0b7e94ae317e05093eb514e86c963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Benzoporphyrin derivative monoacid ring A (BPD-MA)</topic><topic>Biological and medical sciences</topic><topic>Cells, Cultured</topic><topic>Endothelium, Vascular - cytology</topic><topic>Endothelium, Vascular - metabolism</topic><topic>General pharmacology</topic><topic>Humans</topic><topic>Liposomes</topic><topic>Medical sciences</topic><topic>Microscopy, Confocal</topic><topic>Mitochondria - metabolism</topic><topic>Neovascularization, Pathologic - therapy</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Photochemotherapy</topic><topic>Photodynamic therapy (PDT)</topic><topic>Photosensitizing Agents - chemistry</topic><topic>Photosensitizing Agents - pharmacokinetics</topic><topic>Polycation liposome (PCL)</topic><topic>Polyethyleneimine - chemistry</topic><topic>Polyethyleneimine - pharmacokinetics</topic><topic>Polyethylenimine (PEI)</topic><topic>Porphyrins - chemistry</topic><topic>Porphyrins - pharmacokinetics</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takeuchi, Yoshito</creatorcontrib><creatorcontrib>Ichikawa, Kanae</creatorcontrib><creatorcontrib>Yonezawa, Sei</creatorcontrib><creatorcontrib>Kurohane, Kohta</creatorcontrib><creatorcontrib>Koishi, Takayuki</creatorcontrib><creatorcontrib>Nango, Mamoru</creatorcontrib><creatorcontrib>Namba, Yukihiro</creatorcontrib><creatorcontrib>Oku, Naoto</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of controlled release</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takeuchi, Yoshito</au><au>Ichikawa, Kanae</au><au>Yonezawa, Sei</au><au>Kurohane, Kohta</au><au>Koishi, Takayuki</au><au>Nango, Mamoru</au><au>Namba, Yukihiro</au><au>Oku, Naoto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intracellular target for photosensitization in cancer antiangiogenic photodynamic therapy mediated by polycation liposome</atitle><jtitle>Journal of controlled release</jtitle><addtitle>J Control Release</addtitle><date>2004-06-18</date><risdate>2004</risdate><volume>97</volume><issue>2</issue><spage>231</spage><epage>240</epage><pages>231-240</pages><issn>0168-3659</issn><eissn>1873-4995</eissn><coden>JCREEC</coden><abstract>Previous study indicated that antiangiogenic photodynamic therapy (PDT), laser irradiation at 15 min post-injection of photosensitizer in vivo, is effective for cancer treatment, and a photosensitizer, benzoporphyrin derivative monoacid ring A (BPD-MA), encapsulated in polycation liposomes (PCLs), liposomes modified with cetylated polyethylenimine (cetyl-PEI), is more effective than BPD-MA encapsulated in non-modified liposomes [Cancer 97 (2003) 2027]. In the present study, we examined intracellular distribution of BPD-MA. BPD-MA encapsulated in liposomes or in PCLs was incubated with human endothelial cell line ECV304 cells or human umbilical vein endothelial cells (HUVECs), and monitored the intracellular distribution of BPD-MA by confocal laser scan microscopy. BPD-MA was taken up time-dependently into the cells and was distributed in not only cytoplasmic area but also intranuclear region. The enhanced uptake of BPD-MA was observed by the PCL formulation. Intracellular distribution of polycation was monitored by using fluorescein isothiocyanate-labeled cetyl-PEI (cetyl-PEI-FITC) and was colocalized with BPD-MA. Cytoplasmic BPD-MA distribution was partly overlapped with that of rhodamine 123, a mitochondrial fluorostaining probe, suggesting that mitochondrial photosensitization as well as nuclear photosensitization, is involved in the antiangiogenic PDT treatment.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>15196750</pmid><doi>10.1016/j.jconrel.2004.03.030</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0168-3659 |
| ispartof | Journal of controlled release, 2004-06, Vol.97 (2), p.231-240 |
| issn | 0168-3659 1873-4995 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72023822 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Benzoporphyrin derivative monoacid ring A (BPD-MA) Biological and medical sciences Cells, Cultured Endothelium, Vascular - cytology Endothelium, Vascular - metabolism General pharmacology Humans Liposomes Medical sciences Microscopy, Confocal Mitochondria - metabolism Neovascularization, Pathologic - therapy Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Photochemotherapy Photodynamic therapy (PDT) Photosensitizing Agents - chemistry Photosensitizing Agents - pharmacokinetics Polycation liposome (PCL) Polyethyleneimine - chemistry Polyethyleneimine - pharmacokinetics Polyethylenimine (PEI) Porphyrins - chemistry Porphyrins - pharmacokinetics Time Factors |
| title | Intracellular target for photosensitization in cancer antiangiogenic photodynamic therapy mediated by polycation liposome |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-06T04%3A58%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Intracellular%20target%20for%20photosensitization%20in%20cancer%20antiangiogenic%20photodynamic%20therapy%20mediated%20by%20polycation%20liposome&rft.jtitle=Journal%20of%20controlled%20release&rft.au=Takeuchi,%20Yoshito&rft.date=2004-06-18&rft.volume=97&rft.issue=2&rft.spage=231&rft.epage=240&rft.pages=231-240&rft.issn=0168-3659&rft.eissn=1873-4995&rft.coden=JCREEC&rft_id=info:doi/10.1016/j.jconrel.2004.03.030&rft_dat=%3Cproquest_cross%3E72023822%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17603520&rft_id=info:pmid/15196750&rft_els_id=S0168365904001646&rfr_iscdi=true |