Tissue factor binding of activated factor VII triggers smooth muscle cell proliferation via extracellular signal-regulated kinase activation

Tissue factor (TF) is the main initiator of coagulation in vivo. Recently, however, a role for TF as a cell receptor involved in signal transduction has been suggested. The aim of the present study was to assess whether activated factor VII (FVIIa) binding to TF could induce smooth muscle cell (SMC)...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2004-06, Vol.109 (23), p.2911-2916
Hauptverfasser:	CIRILLO, Plinio, CALI, Gaetano, CHIARIELLO, Massimo, GOLINO, Paolo, CALABRO, Paolo, FORTE, Lavinia, DE ROSA, Salvatore, PACILEO, Mario, RAGNI, Massimo, SCOPACASA, Francesco, NITSCH, Lucio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - pharmacology Aorta, Thoracic - cytology Arteriosclerosis - metabolism Binding Sites Biological and medical sciences Blood and lymphatic vessels Blood Coagulation Blood vessels and receptors Butadienes - pharmacology Cardiology. Vascular system Cell Division - drug effects Cells, Cultured - cytology Cells, Cultured - drug effects Cells, Cultured - metabolism Coronary heart disease Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Enzyme Activation Enzyme Inhibitors - pharmacology Factor VIIa - chemistry Factor VIIa - genetics Factor VIIa - metabolism Factor VIIa - pharmacology Fundamental and applied biological sciences. Psychology Heart Humans Inflammation - metabolism Medical sciences Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors Mitogen-Activated Protein Kinase 1 - physiology Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors Mitogen-Activated Protein Kinase 3 - physiology Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - metabolism Myocytes, Smooth Muscle - cytology Myocytes, Smooth Muscle - drug effects Nitriles - pharmacology Phosphorylation - drug effects Protein Binding Protein Processing, Post-Translational - drug effects Rabbits Recombinant Fusion Proteins - metabolism Recombinant Fusion Proteins - pharmacology Signal Transduction - drug effects Thromboplastin - metabolism Vertebrates: cardiovascular system
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