Prenatal heroin exposure alters cholinergic receptor stimulated activation of the PKCbetaII and PKCgamma isoforms

Prenatal exposure of mice to heroin (SC injection of 10mg/kg to the dams on gestational days 9-18) resulted at adulthood in behavioral deficits related to septohippocampal cholinergic innervation accompanied with both presynaptic and postsynaptic cholinergic hyperactivity; including an increase memb...

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Veröffentlicht in:	Brain research bulletin 2004-05, Vol.63 (4), p.339-349
Hauptverfasser:	Yaniv, Shiri P, Naor, Zvi, Yanai, Joseph
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Enzyme Activation - drug effects Enzyme Activation - physiology Female Heroin - pharmacology Hippocampus - drug effects Hippocampus - metabolism Isoenzymes - drug effects Isoenzymes - metabolism Male Mice Narcotics - pharmacology Pregnancy Prenatal Exposure Delayed Effects Protein Kinase C - drug effects Protein Kinase C - metabolism Protein Kinase C beta Protein Transport - drug effects Receptors, Cholinergic - drug effects Receptors, Cholinergic - metabolism
Online-Zugang:	Volltext
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