Lower platelet count in healthy centenarians correlates with dispersion of the QT interval
Centenarians display a lower incidence of vascular ischemic events. A high platelet count and increased QT dispersion (QTd) represents a risk factor for cardiovascular events. The aim of this study was to evaluate platelet count and QTd in healthy centenarians and to establish correlations between t...
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| Veröffentlicht in: | Aging clinical and experimental research 2004-04, Vol.16 (2), p.169-171 |
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| container_title | Aging clinical and experimental research |
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| creator | Gangemi, Sebastiano Basile, Giorgio Merendino, Rosaria Alba Lo Balbo, Claudia Mento, Antonella Nicita-Mauro, Vittorio Franceschi, Claudio Romano, Mario |
| description | Centenarians display a lower incidence of vascular ischemic events. A high platelet count and increased QT dispersion (QTd) represents a risk factor for cardiovascular events. The aim of this study was to evaluate platelet count and QTd in healthy centenarians and to establish correlations between these two indices.
16 healthy centenarians (4 males, 12 females, range 100-105 years) living in a municipality of Eastern Sicily, and 40 healthy control subjects, divided into two groups: group A (N=20), age range 45-65 years, 7 males, 13 females; and group B (N=20), range 65-85 years, 6 males, 14 females, were examined. Platelets were counted using a blood analyzer and QTd was measured in standard 12-lead electrocardiograms. Differences in platelet count were assessed by one-way analysis of variance (ANOVA) and the Bonferroni test. Correlation coefficients between platelet count and QTd were calculated with the Spearman rank test.
Centenarians showed a lower platelet count compared with controls, which was significant with respect to older controls, group B (p |
| doi_str_mv | 10.1007/BF03324547 |
| format | Article |
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16 healthy centenarians (4 males, 12 females, range 100-105 years) living in a municipality of Eastern Sicily, and 40 healthy control subjects, divided into two groups: group A (N=20), age range 45-65 years, 7 males, 13 females; and group B (N=20), range 65-85 years, 6 males, 14 females, were examined. Platelets were counted using a blood analyzer and QTd was measured in standard 12-lead electrocardiograms. Differences in platelet count were assessed by one-way analysis of variance (ANOVA) and the Bonferroni test. Correlation coefficients between platelet count and QTd were calculated with the Spearman rank test.
Centenarians showed a lower platelet count compared with controls, which was significant with respect to older controls, group B (p<0.05). QTd values did not significantly differ between centenarians and controls. A significant correlation between QTd and platelet count was evident in centenarians but not in controls. This correlation became evident in control subjects with a platelet count < or = 240,000/mm3.
We hypothesize that a reduced number of platelets and the maintenance of normal QTd may contribute to extreme longevity and protect centenarians from cardiovascular events.</description><identifier>ISSN: 1594-0667</identifier><identifier>EISSN: 1720-8319</identifier><identifier>DOI: 10.1007/BF03324547</identifier><identifier>PMID: 15195993</identifier><language>eng</language><publisher>Germany: Springer Nature B.V</publisher><subject>Aged ; Aged, 80 and over ; Analysis of Variance ; Blood Platelets - cytology ; Centenarians ; Electrocardiography - statistics & numerical data ; Female ; Heart Rate - physiology ; Humans ; Longevity - physiology ; Male ; Middle Aged ; Myocardial Ischemia - etiology ; Myocardial Ischemia - physiopathology ; Oldest old people ; Platelet Count ; Risk Factors ; Sicily ; Statistics, Nonparametric ; Variance analysis</subject><ispartof>Aging clinical and experimental research, 2004-04, Vol.16 (2), p.169-171</ispartof><rights>Aging Clinical and Experimental Research is a copyright of Springer, (2004). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c311t-86b52c5eb9702c6abcbe7c20ace5c336142ec623d4f502d10838ca74779a8d673</citedby><cites>FETCH-LOGICAL-c311t-86b52c5eb9702c6abcbe7c20ace5c336142ec623d4f502d10838ca74779a8d673</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15195993$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gangemi, Sebastiano</creatorcontrib><creatorcontrib>Basile, Giorgio</creatorcontrib><creatorcontrib>Merendino, Rosaria Alba</creatorcontrib><creatorcontrib>Lo Balbo, Claudia</creatorcontrib><creatorcontrib>Mento, Antonella</creatorcontrib><creatorcontrib>Nicita-Mauro, Vittorio</creatorcontrib><creatorcontrib>Franceschi, Claudio</creatorcontrib><creatorcontrib>Romano, Mario</creatorcontrib><title>Lower platelet count in healthy centenarians correlates with dispersion of the QT interval</title><title>Aging clinical and experimental research</title><addtitle>Aging Clin Exp Res</addtitle><description>Centenarians display a lower incidence of vascular ischemic events. A high platelet count and increased QT dispersion (QTd) represents a risk factor for cardiovascular events. The aim of this study was to evaluate platelet count and QTd in healthy centenarians and to establish correlations between these two indices.
16 healthy centenarians (4 males, 12 females, range 100-105 years) living in a municipality of Eastern Sicily, and 40 healthy control subjects, divided into two groups: group A (N=20), age range 45-65 years, 7 males, 13 females; and group B (N=20), range 65-85 years, 6 males, 14 females, were examined. Platelets were counted using a blood analyzer and QTd was measured in standard 12-lead electrocardiograms. Differences in platelet count were assessed by one-way analysis of variance (ANOVA) and the Bonferroni test. Correlation coefficients between platelet count and QTd were calculated with the Spearman rank test.
Centenarians showed a lower platelet count compared with controls, which was significant with respect to older controls, group B (p<0.05). QTd values did not significantly differ between centenarians and controls. A significant correlation between QTd and platelet count was evident in centenarians but not in controls. This correlation became evident in control subjects with a platelet count < or = 240,000/mm3.
We hypothesize that a reduced number of platelets and the maintenance of normal QTd may contribute to extreme longevity and protect centenarians from cardiovascular events.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Analysis of Variance</subject><subject>Blood Platelets - cytology</subject><subject>Centenarians</subject><subject>Electrocardiography - statistics & numerical data</subject><subject>Female</subject><subject>Heart Rate - physiology</subject><subject>Humans</subject><subject>Longevity - physiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myocardial Ischemia - etiology</subject><subject>Myocardial Ischemia - physiopathology</subject><subject>Oldest old people</subject><subject>Platelet Count</subject><subject>Risk Factors</subject><subject>Sicily</subject><subject>Statistics, Nonparametric</subject><subject>Variance analysis</subject><issn>1594-0667</issn><issn>1720-8319</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkE1Lw0AQhhdRbK1e_AGyIHgQovuZTY5arAoFEerFS9hsJiQlzdbdjaX_3i0tFDzNwPvMy_AgdE3JAyVEPT7PCOdMSKFO0JgqRpKM0_w07jIXCUlTNUIX3i8JETQG52hEJc1lnvMx-p7bDTi87nSADgI2dugDbnvcgO5Cs8UG-gC9dq3ufUydgx3q8aYNDa5avwbnW9tjW-PQAP5cxOMA7ld3l-is1p2Hq8OcoK_Zy2L6lsw_Xt-nT_PEcEpDkqWlZEZCmSvCTKpLU4IyjGgD0nCeUsHApIxXopaEVZRkPDNaCaVynVWp4hN0t-9dO_szgA_FqvUGuk73YAdfRCGMCS4iePsPXNrB9fG3gnGR5YIwkUbqfk8ZZ713UBdr16602xaUFDvfxdF3hG8OlUO5guqIHgTzPzqwehw</recordid><startdate>20040401</startdate><enddate>20040401</enddate><creator>Gangemi, Sebastiano</creator><creator>Basile, Giorgio</creator><creator>Merendino, Rosaria Alba</creator><creator>Lo Balbo, Claudia</creator><creator>Mento, Antonella</creator><creator>Nicita-Mauro, Vittorio</creator><creator>Franceschi, Claudio</creator><creator>Romano, Mario</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20040401</creationdate><title>Lower platelet count in healthy centenarians correlates with dispersion of the QT interval</title><author>Gangemi, Sebastiano ; Basile, Giorgio ; Merendino, Rosaria Alba ; Lo Balbo, Claudia ; Mento, Antonella ; Nicita-Mauro, Vittorio ; Franceschi, Claudio ; Romano, Mario</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-86b52c5eb9702c6abcbe7c20ace5c336142ec623d4f502d10838ca74779a8d673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Analysis of Variance</topic><topic>Blood Platelets - cytology</topic><topic>Centenarians</topic><topic>Electrocardiography - statistics & numerical data</topic><topic>Female</topic><topic>Heart Rate - physiology</topic><topic>Humans</topic><topic>Longevity - physiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Myocardial Ischemia - etiology</topic><topic>Myocardial Ischemia - physiopathology</topic><topic>Oldest old people</topic><topic>Platelet Count</topic><topic>Risk Factors</topic><topic>Sicily</topic><topic>Statistics, Nonparametric</topic><topic>Variance analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gangemi, Sebastiano</creatorcontrib><creatorcontrib>Basile, Giorgio</creatorcontrib><creatorcontrib>Merendino, Rosaria Alba</creatorcontrib><creatorcontrib>Lo Balbo, Claudia</creatorcontrib><creatorcontrib>Mento, Antonella</creatorcontrib><creatorcontrib>Nicita-Mauro, Vittorio</creatorcontrib><creatorcontrib>Franceschi, Claudio</creatorcontrib><creatorcontrib>Romano, Mario</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Aging clinical and experimental research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gangemi, Sebastiano</au><au>Basile, Giorgio</au><au>Merendino, Rosaria Alba</au><au>Lo Balbo, Claudia</au><au>Mento, Antonella</au><au>Nicita-Mauro, Vittorio</au><au>Franceschi, Claudio</au><au>Romano, Mario</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lower platelet count in healthy centenarians correlates with dispersion of the QT interval</atitle><jtitle>Aging clinical and experimental research</jtitle><addtitle>Aging Clin Exp Res</addtitle><date>2004-04-01</date><risdate>2004</risdate><volume>16</volume><issue>2</issue><spage>169</spage><epage>171</epage><pages>169-171</pages><issn>1594-0667</issn><eissn>1720-8319</eissn><abstract>Centenarians display a lower incidence of vascular ischemic events. A high platelet count and increased QT dispersion (QTd) represents a risk factor for cardiovascular events. The aim of this study was to evaluate platelet count and QTd in healthy centenarians and to establish correlations between these two indices.
16 healthy centenarians (4 males, 12 females, range 100-105 years) living in a municipality of Eastern Sicily, and 40 healthy control subjects, divided into two groups: group A (N=20), age range 45-65 years, 7 males, 13 females; and group B (N=20), range 65-85 years, 6 males, 14 females, were examined. Platelets were counted using a blood analyzer and QTd was measured in standard 12-lead electrocardiograms. Differences in platelet count were assessed by one-way analysis of variance (ANOVA) and the Bonferroni test. Correlation coefficients between platelet count and QTd were calculated with the Spearman rank test.
Centenarians showed a lower platelet count compared with controls, which was significant with respect to older controls, group B (p<0.05). QTd values did not significantly differ between centenarians and controls. A significant correlation between QTd and platelet count was evident in centenarians but not in controls. This correlation became evident in control subjects with a platelet count < or = 240,000/mm3.
We hypothesize that a reduced number of platelets and the maintenance of normal QTd may contribute to extreme longevity and protect centenarians from cardiovascular events.</abstract><cop>Germany</cop><pub>Springer Nature B.V</pub><pmid>15195993</pmid><doi>10.1007/BF03324547</doi><tpages>3</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over Analysis of Variance Blood Platelets - cytology Centenarians Electrocardiography - statistics & numerical data Female Heart Rate - physiology Humans Longevity - physiology Male Middle Aged Myocardial Ischemia - etiology Myocardial Ischemia - physiopathology Oldest old people Platelet Count Risk Factors Sicily Statistics, Nonparametric Variance analysis |
| title | Lower platelet count in healthy centenarians correlates with dispersion of the QT interval |
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