Codon optimization and ubiquitin conjugation of human immunodeficiency virus-1 Tat lead to enhanced cell-mediated immune responses

The transactivator protein, Tat, is a potential candidate for developing a vaccine against human immunodeficiency virus (HIV-1). Since Tat is not immunodominant, especially when delivered as a genetic vaccine, we expressed codon-optimized subtype-C Tat as a molecular conjugate of ubiquitin, to elici...

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Veröffentlicht in:Vaccine 2004-06, Vol.22 (20), p.2586-2598
Hauptverfasser: Ramakrishna, Lakshmi, Anand, Krishnamurthy Kumar, Mahalingam, Marthandan, Mohankumar, Kumarasamypet M., Ramani, Shilpa, Siddappa, Nagadenahalli B., Ranga, Udaykumar
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