TRP ion channels in the nervous system
The transient receptor potential (TRP) superfamily comprises a group of non-selective cation channels that sense and respond to changes in their local environments. TRP channels are found in many eukaryotes, from yeast to mammals. They are a diverse group of proteins organized into six families: cla...
Gespeichert in:
| Veröffentlicht in: | Current opinion in neurobiology 2004-06, Vol.14 (3), p.362-369 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 369 |
|---|---|
| container_issue | 3 |
| container_start_page | 362 |
| container_title | Current opinion in neurobiology |
| container_volume | 14 |
| creator | Moran, Magdalene M Xu, Haoxing Clapham, David E |
| description | The transient receptor potential (TRP) superfamily comprises a group of non-selective cation channels that sense and respond to changes in their local environments. TRP channels are found in many eukaryotes, from yeast to mammals. They are a diverse group of proteins organized into six families: classical (TRPC), vanilloid (TRPV), melastatin (TRPM), muclopins (TRPML), polycystin (TRPP), and ANKTM1 (TRPA). In the peripheral nervous system, stimuli including temperature, pressure, inflammatory agents, and receptor activation effect TRP-mediated responses. In the central nervous system, TRPs participate in neurite outgrowth, receptor signalling and excitotoxic cell death resulting from anoxia. TRP channels are emerging as essential cellular switches that allow animals to respond to their environments. |
| doi_str_mv | 10.1016/j.conb.2004.05.003 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72021068</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0959438804000704</els_id><sourcerecordid>72021068</sourcerecordid><originalsourceid>FETCH-LOGICAL-c383t-edf99b3acfcda50204dd6722bcd4870360674855a68634a5d679d684539ba6d43</originalsourceid><addsrcrecordid>eNqFkE1LAzEQQIMotlb_gAfZU2-7Tj43C16k-AUFReo5ZJMs3bLN1mRb6L83pQVveprDvHkMD6FbDAUGLO5Xhel9XRAAVgAvAOgZGmNZ0lxISc7RGCpe5YxKOUJXMa4AQFBJL9EIc1wxjMsxmi4-P7K295lZau9dF7PWZ8PSZd6FXb-NWdzHwa2v0UWju-huTnOCvp6fFrPXfP7-8jZ7nOcmiYfc2aaqaqpNY6zmQIBZK0pCamOZLIEKECWTnGshBWWap2VlhWScVrUWltEJmh69m9B_b10c1LqNxnWd9i59o0oCBIOQ_4K4lEC4JAkkR9CEPsbgGrUJ7VqHvcKgDhnVSh0yqkNGBVyljOno7mTf1mtnf09O3RLwcARSMbdrXVDRtM4bZ9vgzKBs3_7l_wHRaYEd</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17802582</pqid></control><display><type>article</type><title>TRP ion channels in the nervous system</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Moran, Magdalene M ; Xu, Haoxing ; Clapham, David E</creator><creatorcontrib>Moran, Magdalene M ; Xu, Haoxing ; Clapham, David E</creatorcontrib><description>The transient receptor potential (TRP) superfamily comprises a group of non-selective cation channels that sense and respond to changes in their local environments. TRP channels are found in many eukaryotes, from yeast to mammals. They are a diverse group of proteins organized into six families: classical (TRPC), vanilloid (TRPV), melastatin (TRPM), muclopins (TRPML), polycystin (TRPP), and ANKTM1 (TRPA). In the peripheral nervous system, stimuli including temperature, pressure, inflammatory agents, and receptor activation effect TRP-mediated responses. In the central nervous system, TRPs participate in neurite outgrowth, receptor signalling and excitotoxic cell death resulting from anoxia. TRP channels are emerging as essential cellular switches that allow animals to respond to their environments.</description><identifier>ISSN: 0959-4388</identifier><identifier>EISSN: 1873-6882</identifier><identifier>DOI: 10.1016/j.conb.2004.05.003</identifier><identifier>PMID: 15194117</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Calcium Channels - metabolism ; Cell Communication - physiology ; Cell Differentiation - physiology ; Cell Membrane - metabolism ; Cell Membrane - ultrastructure ; Humans ; Nervous System - growth & development ; Nervous System - metabolism ; Nervous System - ultrastructure ; Phylogeny ; Sensation - physiology ; Signal Transduction - physiology ; TRPC Cation Channels</subject><ispartof>Current opinion in neurobiology, 2004-06, Vol.14 (3), p.362-369</ispartof><rights>2004 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c383t-edf99b3acfcda50204dd6722bcd4870360674855a68634a5d679d684539ba6d43</citedby><cites>FETCH-LOGICAL-c383t-edf99b3acfcda50204dd6722bcd4870360674855a68634a5d679d684539ba6d43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0959438804000704$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15194117$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moran, Magdalene M</creatorcontrib><creatorcontrib>Xu, Haoxing</creatorcontrib><creatorcontrib>Clapham, David E</creatorcontrib><title>TRP ion channels in the nervous system</title><title>Current opinion in neurobiology</title><addtitle>Curr Opin Neurobiol</addtitle><description>The transient receptor potential (TRP) superfamily comprises a group of non-selective cation channels that sense and respond to changes in their local environments. TRP channels are found in many eukaryotes, from yeast to mammals. They are a diverse group of proteins organized into six families: classical (TRPC), vanilloid (TRPV), melastatin (TRPM), muclopins (TRPML), polycystin (TRPP), and ANKTM1 (TRPA). In the peripheral nervous system, stimuli including temperature, pressure, inflammatory agents, and receptor activation effect TRP-mediated responses. In the central nervous system, TRPs participate in neurite outgrowth, receptor signalling and excitotoxic cell death resulting from anoxia. TRP channels are emerging as essential cellular switches that allow animals to respond to their environments.</description><subject>Animals</subject><subject>Calcium Channels - metabolism</subject><subject>Cell Communication - physiology</subject><subject>Cell Differentiation - physiology</subject><subject>Cell Membrane - metabolism</subject><subject>Cell Membrane - ultrastructure</subject><subject>Humans</subject><subject>Nervous System - growth & development</subject><subject>Nervous System - metabolism</subject><subject>Nervous System - ultrastructure</subject><subject>Phylogeny</subject><subject>Sensation - physiology</subject><subject>Signal Transduction - physiology</subject><subject>TRPC Cation Channels</subject><issn>0959-4388</issn><issn>1873-6882</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LAzEQQIMotlb_gAfZU2-7Tj43C16k-AUFReo5ZJMs3bLN1mRb6L83pQVveprDvHkMD6FbDAUGLO5Xhel9XRAAVgAvAOgZGmNZ0lxISc7RGCpe5YxKOUJXMa4AQFBJL9EIc1wxjMsxmi4-P7K295lZau9dF7PWZ8PSZd6FXb-NWdzHwa2v0UWju-huTnOCvp6fFrPXfP7-8jZ7nOcmiYfc2aaqaqpNY6zmQIBZK0pCamOZLIEKECWTnGshBWWap2VlhWScVrUWltEJmh69m9B_b10c1LqNxnWd9i59o0oCBIOQ_4K4lEC4JAkkR9CEPsbgGrUJ7VqHvcKgDhnVSh0yqkNGBVyljOno7mTf1mtnf09O3RLwcARSMbdrXVDRtM4bZ9vgzKBs3_7l_wHRaYEd</recordid><startdate>20040601</startdate><enddate>20040601</enddate><creator>Moran, Magdalene M</creator><creator>Xu, Haoxing</creator><creator>Clapham, David E</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20040601</creationdate><title>TRP ion channels in the nervous system</title><author>Moran, Magdalene M ; Xu, Haoxing ; Clapham, David E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c383t-edf99b3acfcda50204dd6722bcd4870360674855a68634a5d679d684539ba6d43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Calcium Channels - metabolism</topic><topic>Cell Communication - physiology</topic><topic>Cell Differentiation - physiology</topic><topic>Cell Membrane - metabolism</topic><topic>Cell Membrane - ultrastructure</topic><topic>Humans</topic><topic>Nervous System - growth & development</topic><topic>Nervous System - metabolism</topic><topic>Nervous System - ultrastructure</topic><topic>Phylogeny</topic><topic>Sensation - physiology</topic><topic>Signal Transduction - physiology</topic><topic>TRPC Cation Channels</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moran, Magdalene M</creatorcontrib><creatorcontrib>Xu, Haoxing</creatorcontrib><creatorcontrib>Clapham, David E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Current opinion in neurobiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moran, Magdalene M</au><au>Xu, Haoxing</au><au>Clapham, David E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>TRP ion channels in the nervous system</atitle><jtitle>Current opinion in neurobiology</jtitle><addtitle>Curr Opin Neurobiol</addtitle><date>2004-06-01</date><risdate>2004</risdate><volume>14</volume><issue>3</issue><spage>362</spage><epage>369</epage><pages>362-369</pages><issn>0959-4388</issn><eissn>1873-6882</eissn><abstract>The transient receptor potential (TRP) superfamily comprises a group of non-selective cation channels that sense and respond to changes in their local environments. TRP channels are found in many eukaryotes, from yeast to mammals. They are a diverse group of proteins organized into six families: classical (TRPC), vanilloid (TRPV), melastatin (TRPM), muclopins (TRPML), polycystin (TRPP), and ANKTM1 (TRPA). In the peripheral nervous system, stimuli including temperature, pressure, inflammatory agents, and receptor activation effect TRP-mediated responses. In the central nervous system, TRPs participate in neurite outgrowth, receptor signalling and excitotoxic cell death resulting from anoxia. TRP channels are emerging as essential cellular switches that allow animals to respond to their environments.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>15194117</pmid><doi>10.1016/j.conb.2004.05.003</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0959-4388 |
| ispartof | Current opinion in neurobiology, 2004-06, Vol.14 (3), p.362-369 |
| issn | 0959-4388 1873-6882 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72021068 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Calcium Channels - metabolism Cell Communication - physiology Cell Differentiation - physiology Cell Membrane - metabolism Cell Membrane - ultrastructure Humans Nervous System - growth & development Nervous System - metabolism Nervous System - ultrastructure Phylogeny Sensation - physiology Signal Transduction - physiology TRPC Cation Channels |
| title | TRP ion channels in the nervous system |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-11T17%3A52%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=TRP%20ion%20channels%20in%20the%20nervous%20system&rft.jtitle=Current%20opinion%20in%20neurobiology&rft.au=Moran,%20Magdalene%20M&rft.date=2004-06-01&rft.volume=14&rft.issue=3&rft.spage=362&rft.epage=369&rft.pages=362-369&rft.issn=0959-4388&rft.eissn=1873-6882&rft_id=info:doi/10.1016/j.conb.2004.05.003&rft_dat=%3Cproquest_cross%3E72021068%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17802582&rft_id=info:pmid/15194117&rft_els_id=S0959438804000704&rfr_iscdi=true |