Cognitive- and motor-related regions in Parkinson's disease: FDOPA and FDG PET studies
Objective: Using 6-[ 18F]fluoro- l-dopa (FDOPA) and [ 18F]fluorodeoxyglucoce (FDG) positron emission tomography (PET), multiple regression analyses were performed to determine the specific brain regions that are related to cognitive and motor symptoms in nondemented patients with Parkinson's di...
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| Veröffentlicht in: | NeuroImage (Orlando, Fla.) Fla.), 2004-06, Vol.22 (2), p.553-561 |
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| creator | Nagano-Saito, Atsuko Kato, Takashi Arahata, Yutaka Washimi, Yukihiko Nakamura, Akinori Abe, Yuji Yamada, Takako Iwai, Katsushige Hatano, Kentaro Kawasumi, Yasuhiro Kachi, Teruhiko Dagher, Alain Ito, Kengo |
| description | Objective: Using 6-[
18F]fluoro-
l-dopa (FDOPA) and [
18F]fluorodeoxyglucoce (FDG) positron emission tomography (PET), multiple regression analyses were performed to determine the specific brain regions that are related to cognitive and motor symptoms in nondemented patients with Parkinson's disease.
Methods: Spatially normalized images of FDOPA influx rate constant (Ki) values and relative regional cerebral metabolic rates for glucose (rrCMRglc) were created. Raven's Coloured Progressive Matrices (RCPM) scores and the Unified Parkinson's Disease Rating Scale (UPDRS) motor scores were used to determine the patients' cognitive and motor functions, respectively. Multiple correlation analyses between the FDOPA and FDG images and the cognitive and motor scores were performed for each voxel.
Results: RCPM score was significantly positively correlated with the FDOPA Ki in the left hippocampus and with the rrCMRglc in the left middle frontal gyrus and right retrosplenial cortex. Motor function was significantly positively correlated with the FDOPA Ki in the bilateral striatum and with the rrCMRglc in association areas and primary visual cortex. The level of motor function was significantly inversely correlated with the FDOPA Ki in the anterior cingulate gyrus and with the rrCMRglc in bilateral primary motor cortex and right putamen.
Conclusions: Changes of striatal FDOPA uptake and rrCMRglc in the primary motor cortex likely represent dysfunction in the motor system involving the corticobasal ganglia-thalamocortical loop. Change of FDOPA uptake in the anterior cingulate gyrus may be related to up-regulation of dopamine synthesis in surviving dopamine neurons. The regions where correlation with cognitive function was observed belong to a cognitive frontoparietal–hippocampal network. |
| doi_str_mv | 10.1016/j.neuroimage.2004.01.030 |
| format | Article |
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18F]fluoro-
l-dopa (FDOPA) and [
18F]fluorodeoxyglucoce (FDG) positron emission tomography (PET), multiple regression analyses were performed to determine the specific brain regions that are related to cognitive and motor symptoms in nondemented patients with Parkinson's disease.
Methods: Spatially normalized images of FDOPA influx rate constant (Ki) values and relative regional cerebral metabolic rates for glucose (rrCMRglc) were created. Raven's Coloured Progressive Matrices (RCPM) scores and the Unified Parkinson's Disease Rating Scale (UPDRS) motor scores were used to determine the patients' cognitive and motor functions, respectively. Multiple correlation analyses between the FDOPA and FDG images and the cognitive and motor scores were performed for each voxel.
Results: RCPM score was significantly positively correlated with the FDOPA Ki in the left hippocampus and with the rrCMRglc in the left middle frontal gyrus and right retrosplenial cortex. Motor function was significantly positively correlated with the FDOPA Ki in the bilateral striatum and with the rrCMRglc in association areas and primary visual cortex. The level of motor function was significantly inversely correlated with the FDOPA Ki in the anterior cingulate gyrus and with the rrCMRglc in bilateral primary motor cortex and right putamen.
Conclusions: Changes of striatal FDOPA uptake and rrCMRglc in the primary motor cortex likely represent dysfunction in the motor system involving the corticobasal ganglia-thalamocortical loop. Change of FDOPA uptake in the anterior cingulate gyrus may be related to up-regulation of dopamine synthesis in surviving dopamine neurons. The regions where correlation with cognitive function was observed belong to a cognitive frontoparietal–hippocampal network.</description><identifier>ISSN: 1053-8119</identifier><identifier>EISSN: 1095-9572</identifier><identifier>DOI: 10.1016/j.neuroimage.2004.01.030</identifier><identifier>PMID: 15193583</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>6-[ 18F]fluoro- l-dopa ; [ 18F]fluorodeoxyglucoce ; Biological Transport ; Brain - diagnostic imaging ; Brain - physiopathology ; Brain Mapping - methods ; Cognition - physiology ; Cognitive ability ; Dementia ; Dihydroxyphenylalanine - analogs & derivatives ; Dihydroxyphenylalanine - pharmacokinetics ; Dopamine ; Female ; Fluorine Radioisotopes ; Fluorodeoxyglucose F18 - pharmacokinetics ; Functional Laterality ; Humans ; Male ; Middle Aged ; Motor Activity - physiology ; Parkinson Disease - physiopathology ; Parkinson's disease ; Positron emission tomography ; Radiopharmaceuticals - pharmacokinetics ; Regression Analysis ; Tomography, Emission-Computed</subject><ispartof>NeuroImage (Orlando, Fla.), 2004-06, Vol.22 (2), p.553-561</ispartof><rights>2004</rights><rights>Copyright Elsevier Limited Jun 1, 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c398t-17dd5b2f3364260b87f03448b1439077bd4b3aead8d655ad5b900606483f9db33</citedby><cites>FETCH-LOGICAL-c398t-17dd5b2f3364260b87f03448b1439077bd4b3aead8d655ad5b900606483f9db33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1506610477?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974,64362,64364,64366,72216</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15193583$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nagano-Saito, Atsuko</creatorcontrib><creatorcontrib>Kato, Takashi</creatorcontrib><creatorcontrib>Arahata, Yutaka</creatorcontrib><creatorcontrib>Washimi, Yukihiko</creatorcontrib><creatorcontrib>Nakamura, Akinori</creatorcontrib><creatorcontrib>Abe, Yuji</creatorcontrib><creatorcontrib>Yamada, Takako</creatorcontrib><creatorcontrib>Iwai, Katsushige</creatorcontrib><creatorcontrib>Hatano, Kentaro</creatorcontrib><creatorcontrib>Kawasumi, Yasuhiro</creatorcontrib><creatorcontrib>Kachi, Teruhiko</creatorcontrib><creatorcontrib>Dagher, Alain</creatorcontrib><creatorcontrib>Ito, Kengo</creatorcontrib><title>Cognitive- and motor-related regions in Parkinson's disease: FDOPA and FDG PET studies</title><title>NeuroImage (Orlando, Fla.)</title><addtitle>Neuroimage</addtitle><description>Objective: Using 6-[
18F]fluoro-
l-dopa (FDOPA) and [
18F]fluorodeoxyglucoce (FDG) positron emission tomography (PET), multiple regression analyses were performed to determine the specific brain regions that are related to cognitive and motor symptoms in nondemented patients with Parkinson's disease.
Methods: Spatially normalized images of FDOPA influx rate constant (Ki) values and relative regional cerebral metabolic rates for glucose (rrCMRglc) were created. Raven's Coloured Progressive Matrices (RCPM) scores and the Unified Parkinson's Disease Rating Scale (UPDRS) motor scores were used to determine the patients' cognitive and motor functions, respectively. Multiple correlation analyses between the FDOPA and FDG images and the cognitive and motor scores were performed for each voxel.
Results: RCPM score was significantly positively correlated with the FDOPA Ki in the left hippocampus and with the rrCMRglc in the left middle frontal gyrus and right retrosplenial cortex. Motor function was significantly positively correlated with the FDOPA Ki in the bilateral striatum and with the rrCMRglc in association areas and primary visual cortex. The level of motor function was significantly inversely correlated with the FDOPA Ki in the anterior cingulate gyrus and with the rrCMRglc in bilateral primary motor cortex and right putamen.
Conclusions: Changes of striatal FDOPA uptake and rrCMRglc in the primary motor cortex likely represent dysfunction in the motor system involving the corticobasal ganglia-thalamocortical loop. Change of FDOPA uptake in the anterior cingulate gyrus may be related to up-regulation of dopamine synthesis in surviving dopamine neurons. The regions where correlation with cognitive function was observed belong to a cognitive frontoparietal–hippocampal network.</description><subject>6-[ 18F]fluoro- l-dopa</subject><subject>[ 18F]fluorodeoxyglucoce</subject><subject>Biological Transport</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - physiopathology</subject><subject>Brain Mapping - methods</subject><subject>Cognition - physiology</subject><subject>Cognitive ability</subject><subject>Dementia</subject><subject>Dihydroxyphenylalanine - analogs & derivatives</subject><subject>Dihydroxyphenylalanine - pharmacokinetics</subject><subject>Dopamine</subject><subject>Female</subject><subject>Fluorine Radioisotopes</subject><subject>Fluorodeoxyglucose F18 - pharmacokinetics</subject><subject>Functional Laterality</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Motor Activity - physiology</subject><subject>Parkinson Disease - physiopathology</subject><subject>Parkinson's disease</subject><subject>Positron emission tomography</subject><subject>Radiopharmaceuticals - pharmacokinetics</subject><subject>Regression Analysis</subject><subject>Tomography, Emission-Computed</subject><issn>1053-8119</issn><issn>1095-9572</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkE1r3DAQhkVpadK0f6EICs3J7sj6sNRbssmmhUD2kOQqZGu8aLsrpZIdyL-vt7sQ6KWnmcPzzjs8hFAGNQOmvm3qiFNOYefWWDcAogZWA4c35JSBkZWRbfN2v0teacbMCflQygYADBP6PTlhkhkuNT8lj4u0jmEMz1hRFz3dpTHlKuPWjehpxnVIsdAQ6crlXyGWFM8L9aGgK_idLq_uVhd_c8urG7q6vqdlnHzA8pG8G9y24KfjPCMPy-v7xY_q9u7m5-Lituq50WPFWu9l1wycK9Eo6HQ7ABdCd0xwA23bedFxh85rr6R0M2sAFCih-WB8x_kZ-Xq4-5TT7wnLaHeh9LjduohpKrZtoAFl9uCXf8BNmnKcf7NMglIMRNvOlD5QfU6lZBzsU54l5xfLwO7N2419NW_35i0wO5ufo5-PBVO3Q_8aPKqegcsDgLOP54DZlj5g7NGHjP1ofQr_b_kD2uSXIQ</recordid><startdate>20040601</startdate><enddate>20040601</enddate><creator>Nagano-Saito, Atsuko</creator><creator>Kato, Takashi</creator><creator>Arahata, Yutaka</creator><creator>Washimi, Yukihiko</creator><creator>Nakamura, Akinori</creator><creator>Abe, Yuji</creator><creator>Yamada, Takako</creator><creator>Iwai, Katsushige</creator><creator>Hatano, Kentaro</creator><creator>Kawasumi, Yasuhiro</creator><creator>Kachi, Teruhiko</creator><creator>Dagher, Alain</creator><creator>Ito, Kengo</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20040601</creationdate><title>Cognitive- and motor-related regions in Parkinson's disease: FDOPA and FDG PET studies</title><author>Nagano-Saito, Atsuko ; Kato, Takashi ; Arahata, Yutaka ; Washimi, Yukihiko ; Nakamura, Akinori ; Abe, Yuji ; Yamada, Takako ; Iwai, Katsushige ; Hatano, Kentaro ; Kawasumi, Yasuhiro ; Kachi, Teruhiko ; Dagher, Alain ; Ito, Kengo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-17dd5b2f3364260b87f03448b1439077bd4b3aead8d655ad5b900606483f9db33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>6-[ 18F]fluoro- l-dopa</topic><topic>[ 18F]fluorodeoxyglucoce</topic><topic>Biological Transport</topic><topic>Brain - diagnostic imaging</topic><topic>Brain - physiopathology</topic><topic>Brain Mapping - methods</topic><topic>Cognition - physiology</topic><topic>Cognitive ability</topic><topic>Dementia</topic><topic>Dihydroxyphenylalanine - analogs & derivatives</topic><topic>Dihydroxyphenylalanine - pharmacokinetics</topic><topic>Dopamine</topic><topic>Female</topic><topic>Fluorine Radioisotopes</topic><topic>Fluorodeoxyglucose F18 - pharmacokinetics</topic><topic>Functional Laterality</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Motor Activity - physiology</topic><topic>Parkinson Disease - physiopathology</topic><topic>Parkinson's disease</topic><topic>Positron emission tomography</topic><topic>Radiopharmaceuticals - pharmacokinetics</topic><topic>Regression Analysis</topic><topic>Tomography, Emission-Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nagano-Saito, Atsuko</creatorcontrib><creatorcontrib>Kato, Takashi</creatorcontrib><creatorcontrib>Arahata, Yutaka</creatorcontrib><creatorcontrib>Washimi, Yukihiko</creatorcontrib><creatorcontrib>Nakamura, Akinori</creatorcontrib><creatorcontrib>Abe, Yuji</creatorcontrib><creatorcontrib>Yamada, Takako</creatorcontrib><creatorcontrib>Iwai, Katsushige</creatorcontrib><creatorcontrib>Hatano, Kentaro</creatorcontrib><creatorcontrib>Kawasumi, Yasuhiro</creatorcontrib><creatorcontrib>Kachi, Teruhiko</creatorcontrib><creatorcontrib>Dagher, Alain</creatorcontrib><creatorcontrib>Ito, Kengo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>NeuroImage (Orlando, Fla.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nagano-Saito, Atsuko</au><au>Kato, Takashi</au><au>Arahata, Yutaka</au><au>Washimi, Yukihiko</au><au>Nakamura, Akinori</au><au>Abe, Yuji</au><au>Yamada, Takako</au><au>Iwai, Katsushige</au><au>Hatano, Kentaro</au><au>Kawasumi, Yasuhiro</au><au>Kachi, Teruhiko</au><au>Dagher, Alain</au><au>Ito, Kengo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cognitive- and motor-related regions in Parkinson's disease: FDOPA and FDG PET studies</atitle><jtitle>NeuroImage (Orlando, Fla.)</jtitle><addtitle>Neuroimage</addtitle><date>2004-06-01</date><risdate>2004</risdate><volume>22</volume><issue>2</issue><spage>553</spage><epage>561</epage><pages>553-561</pages><issn>1053-8119</issn><eissn>1095-9572</eissn><abstract>Objective: Using 6-[
18F]fluoro-
l-dopa (FDOPA) and [
18F]fluorodeoxyglucoce (FDG) positron emission tomography (PET), multiple regression analyses were performed to determine the specific brain regions that are related to cognitive and motor symptoms in nondemented patients with Parkinson's disease.
Methods: Spatially normalized images of FDOPA influx rate constant (Ki) values and relative regional cerebral metabolic rates for glucose (rrCMRglc) were created. Raven's Coloured Progressive Matrices (RCPM) scores and the Unified Parkinson's Disease Rating Scale (UPDRS) motor scores were used to determine the patients' cognitive and motor functions, respectively. Multiple correlation analyses between the FDOPA and FDG images and the cognitive and motor scores were performed for each voxel.
Results: RCPM score was significantly positively correlated with the FDOPA Ki in the left hippocampus and with the rrCMRglc in the left middle frontal gyrus and right retrosplenial cortex. Motor function was significantly positively correlated with the FDOPA Ki in the bilateral striatum and with the rrCMRglc in association areas and primary visual cortex. The level of motor function was significantly inversely correlated with the FDOPA Ki in the anterior cingulate gyrus and with the rrCMRglc in bilateral primary motor cortex and right putamen.
Conclusions: Changes of striatal FDOPA uptake and rrCMRglc in the primary motor cortex likely represent dysfunction in the motor system involving the corticobasal ganglia-thalamocortical loop. Change of FDOPA uptake in the anterior cingulate gyrus may be related to up-regulation of dopamine synthesis in surviving dopamine neurons. The regions where correlation with cognitive function was observed belong to a cognitive frontoparietal–hippocampal network.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>15193583</pmid><doi>10.1016/j.neuroimage.2004.01.030</doi><tpages>9</tpages></addata></record> |
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| ispartof | NeuroImage (Orlando, Fla.), 2004-06, Vol.22 (2), p.553-561 |
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| source | MEDLINE; Elsevier ScienceDirect Journals; ProQuest Central UK/Ireland |
| subjects | 6-[ 18F]fluoro- l-dopa [ 18F]fluorodeoxyglucoce Biological Transport Brain - diagnostic imaging Brain - physiopathology Brain Mapping - methods Cognition - physiology Cognitive ability Dementia Dihydroxyphenylalanine - analogs & derivatives Dihydroxyphenylalanine - pharmacokinetics Dopamine Female Fluorine Radioisotopes Fluorodeoxyglucose F18 - pharmacokinetics Functional Laterality Humans Male Middle Aged Motor Activity - physiology Parkinson Disease - physiopathology Parkinson's disease Positron emission tomography Radiopharmaceuticals - pharmacokinetics Regression Analysis Tomography, Emission-Computed |
| title | Cognitive- and motor-related regions in Parkinson's disease: FDOPA and FDG PET studies |
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