Upregulation of osteopontin expression is involved in the development of nonalcoholic steatohepatitis in a dietary murine model

The pathogenesis of nonalcoholic steatohepatitis (NASH) is poorly defined. Feeding mice a diet deficient in methionine and choline (MCD diet) induces experimental NASH. Osteopontin (OPN) is a Th1 cytokine that plays an important role in several fibroinflammatory diseases. We examined the role of OPN...

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Veröffentlicht in:	American journal of physiology: Gastrointestinal and liver physiology 2004-07, Vol.287 (1), p.G264-G273
Hauptverfasser:	Sahai, Atul, Malladi, Padmini, Melin-Aldana, Hector, Green, Richard M, Whitington, Peter F
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Transaminase - blood Animals Choline Deficiency - complications Collagen Type I - metabolism Diet - adverse effects Fatty Liver - etiology Fatty Liver - metabolism Fatty Liver - pathology Female Hepatocytes - metabolism Liver - metabolism Liver - pathology Liver Cirrhosis - etiology Methionine - deficiency Mice Mice, Inbred Strains Mice, Knockout - genetics Molecular Weight Organ Size Osteopontin Oxidative Stress Sialoglycoproteins - chemistry Sialoglycoproteins - genetics Sialoglycoproteins - metabolism Triglycerides - metabolism Tumor Necrosis Factor-alpha - metabolism Up-Regulation
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